MX345150B - Antigenos ampliamente reactivos computacionalmente optimizados para virus de influenza h5n1 y h1n1. - Google Patents
Antigenos ampliamente reactivos computacionalmente optimizados para virus de influenza h5n1 y h1n1.Info
- Publication number
- MX345150B MX345150B MX2014011387A MX2014011387A MX345150B MX 345150 B MX345150 B MX 345150B MX 2014011387 A MX2014011387 A MX 2014011387A MX 2014011387 A MX2014011387 A MX 2014011387A MX 345150 B MX345150 B MX 345150B
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptides
- influenza
- optimized
- broadly reactive
- influenza viruses
- Prior art date
Links
- 206010069767 H1N1 influenza Diseases 0.000 title abstract 4
- 206010064097 avian influenza Diseases 0.000 title abstract 4
- 201000010740 swine influenza Diseases 0.000 title abstract 4
- 241000712461 unidentified influenza virus Species 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 230000028993 immune response Effects 0.000 abstract 2
- 108091035707 Consensus sequence Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261617815P | 2012-03-30 | 2012-03-30 | |
| PCT/US2013/030530 WO2013148164A1 (en) | 2012-03-30 | 2013-03-12 | Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014011387A MX2014011387A (es) | 2014-10-14 |
| MX345150B true MX345150B (es) | 2017-01-18 |
Family
ID=49261015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014011387A MX345150B (es) | 2012-03-30 | 2013-03-12 | Antigenos ampliamente reactivos computacionalmente optimizados para virus de influenza h5n1 y h1n1. |
Country Status (15)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011302360B2 (en) * | 2010-09-14 | 2015-01-29 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
| CN106995488A (zh) | 2011-06-20 | 2017-08-01 | 高等教育联邦系统-匹兹堡大学 | 计算优化的宽反应性的h1n1流感抗原 |
| HK1212708A1 (zh) * | 2012-11-27 | 2016-06-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | H1n1流感的計算優化的寬反應性抗原 |
| US20140286981A1 (en) | 2013-03-14 | 2014-09-25 | Wisconsin Alumni Research Foundation | Broadly reactive mosaic peptide for influenza vaccine |
| US10548965B2 (en) * | 2014-12-19 | 2020-02-04 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian H5N1 influenza |
| EP3233116A4 (en) * | 2014-12-19 | 2018-05-30 | Oregon Health & Science University | Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza |
| CA2987939A1 (en) * | 2015-06-02 | 2016-12-08 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| AU2016274770B2 (en) * | 2015-06-09 | 2020-11-12 | Sanofi Pasteur, Inc. | Methods of optimizing nucleotide sequences encoding engineered influenza proteins |
| WO2017053413A1 (en) * | 2015-09-21 | 2017-03-30 | Oregon Health & Science University | Vaccines intelligently produced by epitope recombination (viper) for influenza |
| AU2017272344B2 (en) | 2016-06-02 | 2022-03-03 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
| IL312520A (en) * | 2016-06-03 | 2024-07-01 | Sanofi Pasteur Inc | Modification of transgenic influenza hemagglutinin polypeptides |
| JP7329529B2 (ja) * | 2018-03-28 | 2023-08-18 | サノフィ パスツール インコーポレイテッド | ヘマグルチニンを含む広範に防御的なワクチン組成物を生成する方法 |
| WO2019191261A1 (en) * | 2018-03-28 | 2019-10-03 | Sanofi Pasteur Inc. | Methods of generating broadly protective vaccine compositions comprising neuraminidase |
| EP3773698A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Ferritin proteins |
| EP3773703A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Antigenic influenza-ferritin polypeptides |
| MX2021005257A (es) * | 2018-11-06 | 2021-06-18 | Boehringer Ingelheim Vetmedica Gmbh | Composicion inmunogenica contra el subtipo h5 del virus de la influenza aviar. |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1196788C (zh) | 2000-06-23 | 2005-04-13 | 惠氏控股有限公司 | 野生型和嵌合流感病毒样颗粒(vlp)的装配 |
| US20050181459A1 (en) | 2002-06-11 | 2005-08-18 | Matthew Baker | Method for mapping and eliminating T cell epitopes |
| US8592197B2 (en) | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
| CA2598884A1 (en) | 2005-02-24 | 2006-10-05 | University Of Massachusetts | Influenza nucleic acids, polypeptides, and uses thereof |
| WO2007011904A2 (en) | 2005-07-19 | 2007-01-25 | Dow Global Technologies Inc. | Recombinant flu vaccines |
| CA2633793A1 (en) | 2005-12-19 | 2007-06-28 | Novartis Vaccines And Diagnostics S.R.L. | Methods of clustering gene and protein sequences |
| US20080045472A1 (en) | 2006-03-31 | 2008-02-21 | Council Of Scientific And Industrial Research Bharat Biotech | Targets for human micro rnas in avian influenza virus (h5n1) genome |
| EA017203B1 (ru) | 2006-09-07 | 2012-10-30 | Круселл Холланд Б.В. | Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение |
| WO2008091657A1 (en) * | 2007-01-23 | 2008-07-31 | Academia Sinica | Flu vaccines and methods of use thereof |
| WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
| AU2008331673B2 (en) * | 2007-11-12 | 2014-12-11 | The Trustees Of The University Of Pennsylvania | Novel vaccines against multiple subtypes of influenza virus |
| KR101956910B1 (ko) | 2008-01-21 | 2019-03-12 | 메디카고 인코포레이티드 | 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(ＶＬＰｓ) |
| US7981428B2 (en) * | 2008-01-23 | 2011-07-19 | Academia Sinica | Flu vaccines and methods of use thereof |
| US20120034253A1 (en) | 2008-09-25 | 2012-02-09 | Fraunhofer Usa, Inc. | Influenza Vaccines, Antigens, Compositions, and Methods |
| WO2010036948A2 (en) * | 2008-09-26 | 2010-04-01 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Dna prime/inactivated vaccine boost immunization to influenza virus |
| DK2998315T4 (da) | 2009-04-03 | 2022-02-07 | Boehringer Ingelheim Animal Health Usa Inc | Newcastle sygdomsvirus-bårne fuglevacciner |
| US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| AU2011302360B2 (en) * | 2010-09-14 | 2015-01-29 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
| CN106995488A (zh) * | 2011-06-20 | 2017-08-01 | 高等教育联邦系统-匹兹堡大学 | 计算优化的宽反应性的h1n1流感抗原 |
| SG11201404653UA (en) | 2012-02-07 | 2014-09-26 | Univ Pittsburgh | Computationally optimized broadly reactive antigens for h3n2, h2n2, and b influenza viruses |
| CN104144941B (zh) | 2012-02-13 | 2017-06-09 | 高等教育联邦系统-匹兹堡大学 | 以计算方式优化的人和禽h5n1流感的广泛反应性抗原 |
| HK1212708A1 (zh) | 2012-11-27 | 2016-06-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | H1n1流感的計算優化的寬反應性抗原 |
-
2013
- 2013-03-12 EP EP13769077.2A patent/EP2831094B1/en not_active Not-in-force
- 2013-03-12 RU RU2014142785A patent/RU2639551C2/ru not_active IP Right Cessation
- 2013-03-12 RU RU2017141447A patent/RU2017141447A/ru not_active Application Discontinuation
- 2013-03-12 HK HK15104016.5A patent/HK1203522A1/xx unknown
- 2013-03-12 US US14/388,726 patent/US9212207B2/en active Active
- 2013-03-12 CA CA2868330A patent/CA2868330A1/en not_active Abandoned
- 2013-03-12 BR BR112014023900-2A patent/BR112014023900A2/pt not_active IP Right Cessation
- 2013-03-12 WO PCT/US2013/030530 patent/WO2013148164A1/en not_active Ceased
- 2013-03-12 AU AU2013240365A patent/AU2013240365B2/en not_active Ceased
- 2013-03-12 MX MX2014011387A patent/MX345150B/es active IP Right Grant
- 2013-03-12 SG SG11201406153XA patent/SG11201406153XA/en unknown
- 2013-03-12 IN IN7399DEN2014 patent/IN2014DN07399A/en unknown
- 2013-03-12 JP JP2015503258A patent/JP2015513902A/ja active Pending
- 2013-03-12 MY MYPI2014002785A patent/MY166953A/en unknown
- 2013-03-12 KR KR1020147027594A patent/KR20150004800A/ko not_active Withdrawn
- 2013-03-12 CN CN201380027311.0A patent/CN104395336B/zh not_active Expired - Fee Related
-
2015
- 2015-11-12 US US14/939,279 patent/US9555095B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IN2014DN07399A (cg-RX-API-DMAC7.html) | 2015-04-24 |
| JP2015513902A (ja) | 2015-05-18 |
| AU2013240365A1 (en) | 2014-10-23 |
| RU2639551C2 (ru) | 2017-12-21 |
| CA2868330A1 (en) | 2013-10-03 |
| WO2013148164A1 (en) | 2013-10-03 |
| KR20150004800A (ko) | 2015-01-13 |
| HK1203522A1 (en) | 2015-10-30 |
| US20150017196A1 (en) | 2015-01-15 |
| US9212207B2 (en) | 2015-12-15 |
| EP2831094A4 (en) | 2015-10-14 |
| BR112014023900A2 (pt) | 2020-11-24 |
| US20160279226A1 (en) | 2016-09-29 |
| US9555095B2 (en) | 2017-01-31 |
| EP2831094A1 (en) | 2015-02-04 |
| AU2013240365B2 (en) | 2017-03-30 |
| RU2017141447A (ru) | 2019-02-13 |
| SG11201406153XA (en) | 2014-10-30 |
| MX2014011387A (es) | 2014-10-14 |
| EP2831094B1 (en) | 2018-06-13 |
| CN104395336A (zh) | 2015-03-04 |
| RU2014142785A (ru) | 2016-05-20 |
| MY166953A (en) | 2018-07-25 |
| CN104395336B (zh) | 2018-01-23 |
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