CN104395336B - 以计算方式优化的h5n1和h1n1流感病毒的广泛反应性抗原 - Google Patents

以计算方式优化的h5n1和h1n1流感病毒的广泛反应性抗原 Download PDF

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CN104395336B
CN104395336B CN201380027311.0A CN201380027311A CN104395336B CN 104395336 B CN104395336 B CN 104395336B CN 201380027311 A CN201380027311 A CN 201380027311A CN 104395336 B CN104395336 B CN 104395336B
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influenza
protein
virus
polypeptide
vlps
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CN104395336A (zh
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T·M·罗斯
C·J·科雷瓦
D·M·卡特
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CN201380027311.0A 2012-03-30 2013-03-12 以计算方式优化的h5n1和h1n1流感病毒的广泛反应性抗原 Expired - Fee Related CN104395336B (zh)

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US201261617815P 2012-03-30 2012-03-30
US61/617,815 2012-03-30
PCT/US2013/030530 WO2013148164A1 (en) 2012-03-30 2013-03-12 Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses

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EP (1) EP2831094B1 (cg-RX-API-DMAC7.html)
JP (1) JP2015513902A (cg-RX-API-DMAC7.html)
KR (1) KR20150004800A (cg-RX-API-DMAC7.html)
CN (1) CN104395336B (cg-RX-API-DMAC7.html)
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BR (1) BR112014023900A2 (cg-RX-API-DMAC7.html)
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011302360B2 (en) * 2010-09-14 2015-01-29 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for influenza
CN106995488A (zh) 2011-06-20 2017-08-01 高等教育联邦系统-匹兹堡大学 计算优化的宽反应性的h1n1流感抗原
HK1212708A1 (zh) * 2012-11-27 2016-06-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education H1n1流感的計算優化的寬反應性抗原
US20140286981A1 (en) 2013-03-14 2014-09-25 Wisconsin Alumni Research Foundation Broadly reactive mosaic peptide for influenza vaccine
US10548965B2 (en) * 2014-12-19 2020-02-04 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for human and avian H5N1 influenza
EP3233116A4 (en) * 2014-12-19 2018-05-30 Oregon Health & Science University Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza
CA2987939A1 (en) * 2015-06-02 2016-12-08 Sanofi Pasteur Inc. Engineered influenza antigenic polypeptides and immunogenic compositions thereof
AU2016274770B2 (en) * 2015-06-09 2020-11-12 Sanofi Pasteur, Inc. Methods of optimizing nucleotide sequences encoding engineered influenza proteins
WO2017053413A1 (en) * 2015-09-21 2017-03-30 Oregon Health & Science University Vaccines intelligently produced by epitope recombination (viper) for influenza
AU2017272344B2 (en) 2016-06-02 2022-03-03 Sanofi Pasteur Inc. Engineered influenza antigenic polypeptides and immunogenic compositions thereof
IL312520A (en) * 2016-06-03 2024-07-01 Sanofi Pasteur Inc Modification of transgenic influenza hemagglutinin polypeptides
JP7329529B2 (ja) * 2018-03-28 2023-08-18 サノフィ パスツール インコーポレイテッド ヘマグルチニンを含む広範に防御的なワクチン組成物を生成する方法
WO2019191261A1 (en) * 2018-03-28 2019-10-03 Sanofi Pasteur Inc. Methods of generating broadly protective vaccine compositions comprising neuraminidase
EP3773698A1 (en) 2018-04-03 2021-02-17 Sanofi Ferritin proteins
EP3773703A1 (en) 2018-04-03 2021-02-17 Sanofi Antigenic influenza-ferritin polypeptides
MX2021005257A (es) * 2018-11-06 2021-06-18 Boehringer Ingelheim Vetmedica Gmbh Composicion inmunogenica contra el subtipo h5 del virus de la influenza aviar.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012036993A1 (en) * 2010-09-14 2012-03-22 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for influenza

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1196788C (zh) 2000-06-23 2005-04-13 惠氏控股有限公司 野生型和嵌合流感病毒样颗粒(vlp)的装配
US20050181459A1 (en) 2002-06-11 2005-08-18 Matthew Baker Method for mapping and eliminating T cell epitopes
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
CA2598884A1 (en) 2005-02-24 2006-10-05 University Of Massachusetts Influenza nucleic acids, polypeptides, and uses thereof
WO2007011904A2 (en) 2005-07-19 2007-01-25 Dow Global Technologies Inc. Recombinant flu vaccines
CA2633793A1 (en) 2005-12-19 2007-06-28 Novartis Vaccines And Diagnostics S.R.L. Methods of clustering gene and protein sequences
US20080045472A1 (en) 2006-03-31 2008-02-21 Council Of Scientific And Industrial Research Bharat Biotech Targets for human micro rnas in avian influenza virus (h5n1) genome
EA017203B1 (ru) 2006-09-07 2012-10-30 Круселл Холланд Б.В. Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение
WO2008091657A1 (en) * 2007-01-23 2008-07-31 Academia Sinica Flu vaccines and methods of use thereof
WO2009022236A2 (en) 2007-08-16 2009-02-19 Tripep Ab Immunogen platform
AU2008331673B2 (en) * 2007-11-12 2014-12-11 The Trustees Of The University Of Pennsylvania Novel vaccines against multiple subtypes of influenza virus
KR101956910B1 (ko) 2008-01-21 2019-03-12 메디카고 인코포레이티드 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(VLPs)
US7981428B2 (en) * 2008-01-23 2011-07-19 Academia Sinica Flu vaccines and methods of use thereof
US20120034253A1 (en) 2008-09-25 2012-02-09 Fraunhofer Usa, Inc. Influenza Vaccines, Antigens, Compositions, and Methods
WO2010036948A2 (en) * 2008-09-26 2010-04-01 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Dna prime/inactivated vaccine boost immunization to influenza virus
DK2998315T4 (da) 2009-04-03 2022-02-07 Boehringer Ingelheim Animal Health Usa Inc Newcastle sygdomsvirus-bårne fuglevacciner
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
CN106995488A (zh) * 2011-06-20 2017-08-01 高等教育联邦系统-匹兹堡大学 计算优化的宽反应性的h1n1流感抗原
SG11201404653UA (en) 2012-02-07 2014-09-26 Univ Pittsburgh Computationally optimized broadly reactive antigens for h3n2, h2n2, and b influenza viruses
CN104144941B (zh) 2012-02-13 2017-06-09 高等教育联邦系统-匹兹堡大学 以计算方式优化的人和禽h5n1流感的广泛反应性抗原
HK1212708A1 (zh) 2012-11-27 2016-06-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education H1n1流感的計算優化的寬反應性抗原

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012036993A1 (en) * 2010-09-14 2012-03-22 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Computationally optimized broadly reactive antigens for influenza

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Protection against Divergent Influenza H1N1 Virus by a Centralized Influenza Hemagglutinin;Eric A. Weaver et al;《PLoS ONE》;20110301;第6卷(第3期);e18314 *
登录号ABD62843;D. Spiro et al;《GenBank数据库》;20071024;氨基酸序列 *

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JP2015513902A (ja) 2015-05-18
AU2013240365A1 (en) 2014-10-23
RU2639551C2 (ru) 2017-12-21
CA2868330A1 (en) 2013-10-03
WO2013148164A1 (en) 2013-10-03
KR20150004800A (ko) 2015-01-13
HK1203522A1 (en) 2015-10-30
US20150017196A1 (en) 2015-01-15
US9212207B2 (en) 2015-12-15
EP2831094A4 (en) 2015-10-14
BR112014023900A2 (pt) 2020-11-24
US20160279226A1 (en) 2016-09-29
MX345150B (es) 2017-01-18
US9555095B2 (en) 2017-01-31
EP2831094A1 (en) 2015-02-04
AU2013240365B2 (en) 2017-03-30
RU2017141447A (ru) 2019-02-13
SG11201406153XA (en) 2014-10-30
MX2014011387A (es) 2014-10-14
EP2831094B1 (en) 2018-06-13
CN104395336A (zh) 2015-03-04
RU2014142785A (ru) 2016-05-20
MY166953A (en) 2018-07-25

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