MX340816B - Compuestos que inhiben el glioblastoma y su uso. - Google Patents
Compuestos que inhiben el glioblastoma y su uso.Info
- Publication number
- MX340816B MX340816B MX2013014708A MX2013014708A MX340816B MX 340816 B MX340816 B MX 340816B MX 2013014708 A MX2013014708 A MX 2013014708A MX 2013014708 A MX2013014708 A MX 2013014708A MX 340816 B MX340816 B MX 340816B
- Authority
- MX
- Mexico
- Prior art keywords
- glioblastoma
- inhibiting compounds
- compounds
- treatment
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/06—Peri-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se encuentra relacionada a compuestos que inhiben el glioblastoma, en particular a la amida del ácido gambógico y derivados del mismo para el tratamiento del glioblastoma. Más aún, se revelan métodos para determinar si un tratamiento con los compuestos de la invención es adecuado para un paciente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161497215P | 2011-06-15 | 2011-06-15 | |
PCT/EP2012/061485 WO2012172069A1 (en) | 2011-06-15 | 2012-06-15 | Glioblastoma inhibiting compounds and their use |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013014708A MX2013014708A (es) | 2014-08-18 |
MX340816B true MX340816B (es) | 2016-07-26 |
Family
ID=46319762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013014708A MX340816B (es) | 2011-06-15 | 2012-06-15 | Compuestos que inhiben el glioblastoma y su uso. |
Country Status (13)
Country | Link |
---|---|
US (1) | US9573960B2 (es) |
EP (1) | EP2721035B1 (es) |
JP (1) | JP6228113B2 (es) |
CN (1) | CN103764659A (es) |
AU (1) | AU2012268984B2 (es) |
BR (1) | BR112013032360A2 (es) |
CA (1) | CA2838945A1 (es) |
CL (1) | CL2013003563A1 (es) |
IL (1) | IL229767A0 (es) |
MX (1) | MX340816B (es) |
RU (1) | RU2014101070A (es) |
WO (1) | WO2012172069A1 (es) |
ZA (1) | ZA201309365B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014023329A1 (en) * | 2012-08-06 | 2014-02-13 | Life And Brain Gmbh | Niclosamide and its derivatives for use in the treatment of solid tumors |
WO2016210289A1 (en) | 2015-06-24 | 2016-12-29 | Duke University | Chemical modulators of signaling pathways and therapeutic use |
EP3328495A4 (en) * | 2015-07-31 | 2019-01-16 | Swedish Health Services | METHODS AND COMPOSITIONS FOR CHARACTERIZING MULTIPLE-FORM GLIOBLASTOMA TUMORS AND CANCER STEM CELLS |
US11499972B2 (en) | 2015-09-15 | 2022-11-15 | Swedish Health Services | Methods and panels of compounds for characterization of glioblastoma multiforme tumors and cancer stem cells thereof |
CN105802928A (zh) * | 2016-03-30 | 2016-07-27 | 苏州偲聚生物材料有限公司 | 用于检测血清中mgmt抗体的多肽,检测器件和检测试剂盒 |
CN105796549A (zh) * | 2016-04-22 | 2016-07-27 | 中国医学科学院基础医学研究所 | 藤黄酰胺用于制备治疗人神经胶质瘤的药物的用途 |
CN107475213A (zh) * | 2016-06-08 | 2017-12-15 | 中国科学院苏州纳米技术与纳米仿生研究所 | 用于检测血清中mgmt抗体的多肽,检测器件和检测试剂盒 |
US11311606B2 (en) | 2018-03-13 | 2022-04-26 | Georgetown University | Enhancing chemotherapy in medulloblastoma and glioblastoma with high basal p53 levels |
CN110433154A (zh) * | 2019-08-12 | 2019-11-12 | 昆明理工大学 | 藤黄酸的新用途 |
WO2023183463A1 (en) * | 2022-03-23 | 2023-09-28 | University Of Cincinnati | Methods of potentiating temozolomide activity against glioblastoma cells |
CN117538458B (zh) * | 2024-01-09 | 2024-03-29 | 中国医学科学院北京协和医院 | 同时定量分析14种单糖/二糖的液相色谱串联质谱分析方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2864100A (en) * | 1999-02-01 | 2000-08-18 | Cytovia, Inc. | Methods of identifying therapeutically effective antineoplastic agents with cultured cells having intact cell membranes and corresponding products |
US6462041B1 (en) * | 1999-05-21 | 2002-10-08 | Cytovia, Inc. | Gambogic acid, analogs and derivatives as activators of caspases and inducers of apoptosis |
JP3904364B2 (ja) | 2000-03-03 | 2007-04-11 | 独立行政法人科学技術振興機構 | 抗マラリア活性を有する新規化合物 |
EP1300403A1 (en) * | 2001-10-02 | 2003-04-09 | Aventis Pharma S.A. | Process for the manufacture of hypoxyxylerone derivatives |
WO2008148008A1 (en) * | 2007-05-23 | 2008-12-04 | Emory University | High throughput bioassay for identifying selective trka receptor agonists, and gambogic amide, a selective trka agonist with neuroprotective activity |
CN101289482B (zh) * | 2007-09-29 | 2011-08-31 | 辽宁利锋科技开发有限公司 | 藤黄酸苷衍生物和类似物及其制备方法和用途 |
PA8851101A1 (es) * | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
-
2012
- 2012-06-15 AU AU2012268984A patent/AU2012268984B2/en not_active Expired - Fee Related
- 2012-06-15 US US14/126,512 patent/US9573960B2/en active Active
- 2012-06-15 CA CA2838945A patent/CA2838945A1/en not_active Abandoned
- 2012-06-15 CN CN201280028960.8A patent/CN103764659A/zh active Pending
- 2012-06-15 BR BR112013032360A patent/BR112013032360A2/pt not_active IP Right Cessation
- 2012-06-15 MX MX2013014708A patent/MX340816B/es active IP Right Grant
- 2012-06-15 WO PCT/EP2012/061485 patent/WO2012172069A1/en active Application Filing
- 2012-06-15 EP EP12728260.6A patent/EP2721035B1/en not_active Not-in-force
- 2012-06-15 RU RU2014101070/04A patent/RU2014101070A/ru not_active Application Discontinuation
- 2012-06-15 JP JP2014515214A patent/JP6228113B2/ja not_active Expired - Fee Related
-
2013
- 2013-12-02 IL IL229767A patent/IL229767A0/en unknown
- 2013-12-11 ZA ZA2013/09365A patent/ZA201309365B/en unknown
- 2013-12-12 CL CL2013003563A patent/CL2013003563A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN103764659A (zh) | 2014-04-30 |
ZA201309365B (en) | 2015-11-25 |
CL2013003563A1 (es) | 2014-06-06 |
RU2014101070A (ru) | 2015-07-20 |
US20150148390A1 (en) | 2015-05-28 |
WO2012172069A1 (en) | 2012-12-20 |
MX2013014708A (es) | 2014-08-18 |
BR112013032360A2 (pt) | 2017-06-13 |
EP2721035B1 (en) | 2018-06-13 |
CA2838945A1 (en) | 2012-12-20 |
JP2014517025A (ja) | 2014-07-17 |
AU2012268984B2 (en) | 2016-07-14 |
EP2721035A1 (en) | 2014-04-23 |
NZ618170A (en) | 2015-04-24 |
JP6228113B2 (ja) | 2017-11-08 |
US9573960B2 (en) | 2017-02-21 |
IL229767A0 (en) | 2014-01-30 |
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Legal Events
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FG | Grant or registration |