MX339427B - Biomarcadores de plasma de sangre para terapias de combinacion con bevacizumab para tratamiento de cancer pancreatico. - Google Patents
Biomarcadores de plasma de sangre para terapias de combinacion con bevacizumab para tratamiento de cancer pancreatico.Info
- Publication number
- MX339427B MX339427B MX2013000671A MX2013000671A MX339427B MX 339427 B MX339427 B MX 339427B MX 2013000671 A MX2013000671 A MX 2013000671A MX 2013000671 A MX2013000671 A MX 2013000671A MX 339427 B MX339427 B MX 339427B
- Authority
- MX
- Mexico
- Prior art keywords
- pancreatic cancer
- blood plasma
- expression level
- treatment
- combination therapies
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
La presente invención se refiere a métodos para mejorar el efecto de tratamiento de un régimen de quimioterapia de un paciente que sufre cáncer pancreático, en particular cáncer pancreático metastásico, al agregar bevacizumab (Avastin(r)) a un régimen de quimioterapia, al determinar el nivel de expresión, en particular el nivel de expresión en plasma de sangre, de uno o más de VEGFA, VEGFR2 y PLGF respecto a niveles de control de pacientes diagnosticados con cáncer pancreático, en particular cáncer pancreático metastásico. En particular, la presente invención proporciona métodos para mejorar el efecto de tratamiento, en donde el efecto de tratamiento es la supervivencia global y/o la supervivencia libre de progreso del paciente. La presente invención además proporciona métodos para estimar la sensibilidad o respuesta de un paciente a bevacizumab (Avastin(r)) en combinación con un régimen de quimioterapia, al determinar el nivel de expresión, en particular el nivel de expresión en plasma de sangre, de uno o más de VEGFA, VEGFR2 y PLGF respecto a niveles de control en pacientes con diagnóstico de cáncer pancreático, en particular cáncer pancreático metastásico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10170004 | 2010-07-19 | ||
PCT/EP2011/062226 WO2012010546A1 (en) | 2010-07-19 | 2011-07-18 | Blood plasma biomarkers for bevacizumab combination therapies for treatment of pancreatic cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013000671A MX2013000671A (es) | 2013-02-27 |
MX339427B true MX339427B (es) | 2016-05-25 |
Family
ID=44509259
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013000671A MX339427B (es) | 2010-07-19 | 2011-07-18 | Biomarcadores de plasma de sangre para terapias de combinacion con bevacizumab para tratamiento de cancer pancreatico. |
Country Status (14)
Country | Link |
---|---|
US (4) | US20130108626A1 (es) |
EP (1) | EP2596364B1 (es) |
JP (1) | JP5963005B2 (es) |
KR (1) | KR20130091746A (es) |
CN (1) | CN103140761B (es) |
AU (1) | AU2011281700B2 (es) |
BR (1) | BR112012033423A2 (es) |
CA (1) | CA2804348A1 (es) |
ES (1) | ES2560219T3 (es) |
HK (1) | HK1181459A1 (es) |
MX (1) | MX339427B (es) |
RU (1) | RU2582964C2 (es) |
SG (1) | SG187012A1 (es) |
WO (1) | WO2012010546A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
US9116159B2 (en) | 2012-05-22 | 2015-08-25 | Regeneron Pharmaceuticals, Inc. | VEGF-A121 assay |
KR101850591B1 (ko) * | 2012-10-05 | 2018-04-19 | 제넨테크, 인크. | 염증성 장 질환의 진단 및 치료 방법 |
MX2017001980A (es) | 2014-08-28 | 2017-05-04 | Eisai R&D Man Co Ltd | Derivado de quinolina muy puro y metodo para su produccion. |
SG11201706630UA (en) | 2015-02-25 | 2017-09-28 | Eisai R&D Man Co Ltd | Method for suppressing bitterness of quinoline derivative |
AU2015384801B2 (en) | 2015-03-04 | 2022-01-06 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer |
JP6757337B2 (ja) * | 2015-05-29 | 2020-09-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | レンバチニブ及びエベロリムスを含む組合せ療法のためのバイオマーカー |
MX2017015896A (es) | 2015-06-16 | 2018-08-09 | Eisai R&D Man Co Ltd | Agente anticancerigeno. |
JP2019523404A (ja) * | 2016-07-15 | 2019-08-22 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 全vegf−aのレベルを検出するための方法及び手段 |
GR1009946B (el) * | 2019-06-25 | 2021-03-04 | ΕΝΟΡΑΣΙΣ ΑΝΩΝΥΜΗ ΕΜΠΟΡΙΚΗ ΕΤΑΙΡΕΙΑ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΚΑΙ ΙΑΤΡΙΚΩΝ ΥΛΙΚΩΝ ΚΑΙ ΜΗΧΑΝΗΜΑΤΩΝ με δ.τ. "ΕΝΟΡΑΣΙΣ Α.Ε." | Οι συγκεντρωσεις της μπεβασιζουμαμπης σαν δεικτης στην ανταποκριση στη θεραπεια και στη συνολικη επιβιωση |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19806989A1 (de) | 1998-02-19 | 1999-08-26 | Roche Diagnostics Gmbh | Erzeugung räumlich scharf begrenzter Festphasen für Bindungsassays |
EA200500232A1 (ru) * | 2002-07-19 | 2005-12-29 | Бет Изрейэл Диконисс Медикал Сентер | Способы диагностики и лечения преэклампсии или эклампсии |
US7435419B2 (en) * | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
DE602004023183D1 (de) * | 2003-03-07 | 2009-10-29 | Univ Texas | Gegen antikörper gerichtete photodynamische therapie |
EP2583685A1 (en) * | 2004-06-10 | 2013-04-24 | Regeneron Pharmaceuticals, Inc. | Method of administering and using VEGF inhibitors for the treatment of human cancer |
DE102004029909A1 (de) | 2004-06-21 | 2006-01-19 | Roche Diagnostics Gmbh | Verfahren und Vorrichtung zur Herstellung von bindungsfähigen Reagenzträgern |
ATE549358T1 (de) * | 2005-03-24 | 2012-03-15 | Thrombogenics Nv | Neuer anti-plgf-antikörper |
DK2056874T3 (da) * | 2006-08-21 | 2012-10-15 | Hoffmann La Roche | Tumorterapi med et anti-vegf-antistof |
CN101646450A (zh) * | 2006-12-19 | 2010-02-10 | 基因技术公司 | 用于辅助和新辅助疗法以及早期肿瘤的治疗的vegf特异性拮抗剂 |
PL2101807T3 (pl) * | 2006-12-19 | 2016-11-30 | Antagoniści specyficzni względem VEGF dla terapii adiuwantem i neoadiuwantem i leczenie wczesnych stadiów guzów | |
US20080199464A1 (en) * | 2007-02-01 | 2008-08-21 | Genentech, Inc. | Combination Therapy with Angiogenesis Inhibitors |
ATE516814T1 (de) * | 2007-02-02 | 2011-08-15 | Bristol Myers Squibb Co | 10fn3 domain zur behandlung von krankheiten begleitet von unerwünschter angiogenese |
MX2011002082A (es) * | 2008-08-29 | 2011-06-20 | Genentech Inc | Diagnostico y tratamientos para los tumores independientes del vegf. |
US20100082438A1 (en) * | 2008-10-01 | 2010-04-01 | Ronnie Jack Garmon | Methods and systems for customer performance scoring |
BRPI0918211A2 (pt) * | 2008-12-23 | 2015-12-08 | Genentech Inc | métodos de identificação de um paciente, métodos de predição da responsividade de um paciente, métodos de monitoramento, métodos de otimização da eficácia terapêutica e kit para detecção do níveis de expressão de p1gf |
-
2011
- 2011-07-18 SG SG2013001938A patent/SG187012A1/en unknown
- 2011-07-18 AU AU2011281700A patent/AU2011281700B2/en not_active Ceased
- 2011-07-18 ES ES11748601.9T patent/ES2560219T3/es active Active
- 2011-07-18 CA CA2804348A patent/CA2804348A1/en not_active Abandoned
- 2011-07-18 KR KR1020137004032A patent/KR20130091746A/ko not_active Application Discontinuation
- 2011-07-18 MX MX2013000671A patent/MX339427B/es active IP Right Grant
- 2011-07-18 BR BR112012033423A patent/BR112012033423A2/pt not_active IP Right Cessation
- 2011-07-18 EP EP11748601.9A patent/EP2596364B1/en not_active Not-in-force
- 2011-07-18 RU RU2013106940/15A patent/RU2582964C2/ru not_active IP Right Cessation
- 2011-07-18 JP JP2013520100A patent/JP5963005B2/ja not_active Expired - Fee Related
- 2011-07-18 CN CN201180044879.4A patent/CN103140761B/zh not_active Expired - Fee Related
- 2011-07-18 WO PCT/EP2011/062226 patent/WO2012010546A1/en active Application Filing
-
2012
- 2012-12-27 US US13/728,333 patent/US20130108626A1/en not_active Abandoned
-
2013
- 2013-03-13 US US13/801,541 patent/US20130195857A1/en not_active Abandoned
- 2013-03-13 US US13/801,628 patent/US20130183301A1/en not_active Abandoned
- 2013-07-25 HK HK13108724.1A patent/HK1181459A1/zh not_active IP Right Cessation
-
2014
- 2014-06-20 US US14/310,571 patent/US20140302019A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20130183301A1 (en) | 2013-07-18 |
US20130108626A1 (en) | 2013-05-02 |
EP2596364A1 (en) | 2013-05-29 |
CN103140761B (zh) | 2015-11-25 |
MX2013000671A (es) | 2013-02-27 |
HK1181459A1 (zh) | 2013-11-08 |
JP2013538337A (ja) | 2013-10-10 |
RU2582964C2 (ru) | 2016-04-27 |
US20130195857A1 (en) | 2013-08-01 |
AU2011281700A1 (en) | 2012-12-20 |
BR112012033423A2 (pt) | 2016-10-25 |
US20140302019A1 (en) | 2014-10-09 |
EP2596364B1 (en) | 2015-12-16 |
KR20130091746A (ko) | 2013-08-19 |
RU2013106940A (ru) | 2014-08-27 |
WO2012010546A1 (en) | 2012-01-26 |
JP5963005B2 (ja) | 2016-08-03 |
CA2804348A1 (en) | 2012-01-26 |
AU2011281700B2 (en) | 2017-02-09 |
CN103140761A (zh) | 2013-06-05 |
SG187012A1 (en) | 2013-02-28 |
ES2560219T3 (es) | 2016-02-17 |
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