WO2011153345A3 - A gene expression profile of brca-ness that correlates with responsiveness to chemotherapy and with outcome in cancer patients - Google Patents

A gene expression profile of brca-ness that correlates with responsiveness to chemotherapy and with outcome in cancer patients Download PDF

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Publication number
WO2011153345A3
WO2011153345A3 PCT/US2011/038922 US2011038922W WO2011153345A3 WO 2011153345 A3 WO2011153345 A3 WO 2011153345A3 US 2011038922 W US2011038922 W US 2011038922W WO 2011153345 A3 WO2011153345 A3 WO 2011153345A3
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WO
WIPO (PCT)
Prior art keywords
gene expression
expression profile
brca
ness
responsiveness
Prior art date
Application number
PCT/US2011/038922
Other languages
French (fr)
Other versions
WO2011153345A2 (en
Inventor
Stephen Cannistra
Panagiotis Konstantinopoulos
Original Assignee
Beth Israel Deaconess Medical Center, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Center, Inc. filed Critical Beth Israel Deaconess Medical Center, Inc.
Publication of WO2011153345A2 publication Critical patent/WO2011153345A2/en
Publication of WO2011153345A3 publication Critical patent/WO2011153345A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Aspects of the invention provide methods and compositions for evaluating cells and tissues based on gene expression profiles to determine their sensitivity or resistance to one or more chemotherapeutic agents. A patient having a tumor or cancer can be evaluated using a gene expression profile to assist in determining the disease prognosis, selecting an appropriate therapy, and/or predicting drug resistance or sensitivity.
PCT/US2011/038922 2010-06-03 2011-06-02 A gene expression profile of brca-ness that correlates with responsiveness to chemotherapy and with outcome in cancer patients WO2011153345A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35128210P 2010-06-03 2010-06-03
US61/351,282 2010-06-03

Publications (2)

Publication Number Publication Date
WO2011153345A2 WO2011153345A2 (en) 2011-12-08
WO2011153345A3 true WO2011153345A3 (en) 2012-03-15

Family

ID=45067295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/038922 WO2011153345A2 (en) 2010-06-03 2011-06-02 A gene expression profile of brca-ness that correlates with responsiveness to chemotherapy and with outcome in cancer patients

Country Status (1)

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WO (1) WO2011153345A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170058351A1 (en) * 2013-11-28 2017-03-02 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Methods for Molecular Classification of BRCA-Like Breast and/or Ovarian Cancer
AU2015369624A1 (en) * 2014-12-23 2017-06-08 Genentech, Inc. Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
GB2553736A (en) 2015-05-19 2018-03-14 S Sridhar T Method for identification of a deficient BRCA1 function
WO2019079297A1 (en) 2017-10-16 2019-04-25 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
US20230346980A1 (en) * 2022-04-29 2023-11-02 Tiba Biotech Tail-conjugated rnas

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060246470A1 (en) * 2004-12-06 2006-11-02 Suzanne Fuqua RNA expression profile predicting response to tamoxifen in breast cancer patients

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060246470A1 (en) * 2004-12-06 2006-11-02 Suzanne Fuqua RNA expression profile predicting response to tamoxifen in breast cancer patients

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MARKMAN ET AL.: "Second-Line Treatment of Ovarian Cancer", THE ONCOLOGIST, vol. 5, no. 1, 2000, pages 26 - 35 *

Also Published As

Publication number Publication date
WO2011153345A2 (en) 2011-12-08

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