MX2024003968A - Profarmacos de axitinib. - Google Patents
Profarmacos de axitinib.Info
- Publication number
- MX2024003968A MX2024003968A MX2024003968A MX2024003968A MX2024003968A MX 2024003968 A MX2024003968 A MX 2024003968A MX 2024003968 A MX2024003968 A MX 2024003968A MX 2024003968 A MX2024003968 A MX 2024003968A MX 2024003968 A MX2024003968 A MX 2024003968A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- sub
- oco
- och
- cooh
- Prior art date
Links
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 title 1
- 229960003005 axitinib Drugs 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163255998P | 2021-10-15 | 2021-10-15 | |
| PCT/US2022/046750 WO2023064578A1 (en) | 2021-10-15 | 2022-10-14 | Prodrugs of axitinib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024003968A true MX2024003968A (es) | 2024-04-29 |
Family
ID=85987895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2024003968A MX2024003968A (es) | 2021-10-15 | 2022-10-14 | Profarmacos de axitinib. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250092013A1 (enExample) |
| EP (1) | EP4416132A4 (enExample) |
| JP (1) | JP2024537839A (enExample) |
| CN (1) | CN118119599A (enExample) |
| AU (1) | AU2022362310A1 (enExample) |
| CA (1) | CA3232086A1 (enExample) |
| MX (1) | MX2024003968A (enExample) |
| WO (1) | WO2023064578A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024081410A1 (en) * | 2022-10-14 | 2024-04-18 | Ocular Therapeutix, Inc. | Prodrugs, formulations and methods thereof |
| AU2024251447A1 (en) | 2023-04-11 | 2025-08-21 | Ocular Therapeutix, Inc. | Ocular implant comprising axitinib polymorph iv |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5721949B2 (ja) * | 2006-10-12 | 2015-05-20 | アステックス、セラピューティックス、リミテッドＡｓｔｅｘ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | 複合薬剤 |
| TWI664965B (zh) * | 2015-06-22 | 2019-07-11 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法 |
| US20210078970A1 (en) * | 2019-08-30 | 2021-03-18 | Risen (Suzhou) Pharma Tech Co., Ltd. | Prodrugs of the tyrosine kinase inhibitor for treating cancer |
| WO2021035360A1 (en) * | 2019-08-30 | 2021-03-04 | Risen (Suzhou) Pharma Tech Co., Ltd. | Prodrugs of the tyrosine kinase inhibitor for treating cancer |
| CN112442010B (zh) * | 2019-08-30 | 2023-10-03 | 润佳（苏州）医药科技有限公司 | 一类前药化合物及其在治疗癌症方面的应用 |
-
2022
- 2022-10-14 CN CN202280066784.0A patent/CN118119599A/zh active Pending
- 2022-10-14 CA CA3232086A patent/CA3232086A1/en active Pending
- 2022-10-14 JP JP2024519989A patent/JP2024537839A/ja active Pending
- 2022-10-14 WO PCT/US2022/046750 patent/WO2023064578A1/en not_active Ceased
- 2022-10-14 AU AU2022362310A patent/AU2022362310A1/en active Pending
- 2022-10-14 US US18/706,306 patent/US20250092013A1/en active Pending
- 2022-10-14 MX MX2024003968A patent/MX2024003968A/es unknown
- 2022-10-14 EP EP22881846.4A patent/EP4416132A4/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024537839A (ja) | 2024-10-16 |
| US20250092013A1 (en) | 2025-03-20 |
| EP4416132A1 (en) | 2024-08-21 |
| WO2023064578A1 (en) | 2023-04-20 |
| CN118119599A (zh) | 2024-05-31 |
| EP4416132A4 (en) | 2025-09-03 |
| AU2022362310A1 (en) | 2024-04-11 |
| CA3232086A1 (en) | 2023-04-20 |
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