MX2023013300A - Metodos de fabricacion de un compuesto de heparina de alto peso molecular. - Google Patents
Metodos de fabricacion de un compuesto de heparina de alto peso molecular.Info
- Publication number
- MX2023013300A MX2023013300A MX2023013300A MX2023013300A MX2023013300A MX 2023013300 A MX2023013300 A MX 2023013300A MX 2023013300 A MX2023013300 A MX 2023013300A MX 2023013300 A MX2023013300 A MX 2023013300A MX 2023013300 A MX2023013300 A MX 2023013300A
- Authority
- MX
- Mexico
- Prior art keywords
- molecular weight
- heparin
- high molecular
- kda
- manufacturing
- Prior art date
Links
- 229960002897 heparin Drugs 0.000 title abstract 10
- 229920000669 heparin Polymers 0.000 title abstract 10
- -1 heparin compound Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 8
- 238000009295 crossflow filtration Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000012465 retentate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/10—Heparin; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Sustainable Development (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Se describe un método para fabricar un compuesto de heparina de alto peso molecular (HMWH). El método comprende disolver heparina para formar una solución de heparina y fraccionar la solución de heparina mediante filtración de flujo tangencial (TFF) usando una membrana con un corte de peso molecular (MWCO) entre aproximadamente 8 kDa y aproximadamente 12 kDa. La TFF produce un retenido que comprende heparina fraccionada con un peso molecular promedio en peso de aproximadamente 20 kDa o mayor, es decir, un compuesto de heparina de alto peso molecular. Una proporción sustancial de cadenas de heparina en la heparina fraccionada puede tener un peso molecular alto, por ejemplo, el 50 % de las cadenas de heparina o más pueden tener un peso molecular de 20 kDa o mayor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163187624P | 2021-05-12 | 2021-05-12 | |
| PCT/US2022/029014 WO2022241130A1 (en) | 2021-05-12 | 2022-05-12 | Methods of manufacturing a high molecular weight heparin compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023013300A true MX2023013300A (es) | 2023-12-04 |
Family
ID=81927418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023013300A MX2023013300A (es) | 2021-05-12 | 2022-05-12 | Metodos de fabricacion de un compuesto de heparina de alto peso molecular. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11712447B2 (es) |
| EP (1) | EP4326782A1 (es) |
| JP (1) | JP2024518174A (es) |
| KR (1) | KR20240006648A (es) |
| CN (1) | CN117295772A (es) |
| AU (1) | AU2022273722A1 (es) |
| BR (1) | BR112023022331A2 (es) |
| CA (1) | CA3217273A1 (es) |
| IL (1) | IL308411A (es) |
| MX (1) | MX2023013300A (es) |
| WO (1) | WO2022241130A1 (es) |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE35770E (en) * | 1978-11-06 | 1998-04-14 | Choay, S.A. | Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them |
| US4446126A (en) | 1980-09-30 | 1984-05-01 | Cutter Laboratories, Inc. | Antithrombin-heparin complex and method for its production |
| US4539398A (en) | 1982-01-22 | 1985-09-03 | Riker Laboratories, Inc. | Affinity fractionation of heparin on immobilized Concanavalin A |
| IT1290814B1 (it) | 1997-03-24 | 1998-12-11 | Istituto Scient Di Chimica E B | Glicosaminoglicani aventi elevata attivita' antitrombotica |
| AU2745700A (en) | 1999-02-01 | 2000-08-18 | Dermal Research Laboratories, Inc. | A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
| JP2009538386A (ja) * | 2006-05-25 | 2009-11-05 | モメンタ ファーマシューティカルズ インコーポレイテッド | 低分子量ヘパリン組成物およびその使用 |
| GB0812919D0 (en) * | 2008-07-15 | 2008-08-20 | Norwegian University Of Life Sciences | Process |
| GB0908129D0 (en) | 2009-05-12 | 2009-06-24 | Innovata Ltd | Composition |
| WO2011097148A2 (en) | 2010-02-04 | 2011-08-11 | Parsons Lowell C | Use of oral heparin preparations to treat urinary tract diseases and conditions |
| WO2013120497A1 (en) | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein |
| WO2013173716A2 (en) | 2012-05-18 | 2013-11-21 | University Of Utah Research Foundation | Methods for diagnosing and monitoring eosinophilic esophagitis |
| BR102014027804B1 (pt) | 2014-11-07 | 2020-12-01 | Universidade Estadual Paulista Julio De Mesquita Filho | processo de desenvolvimento de heparina não fracionada de alto peso molecular, heparina não fracionada de alto peso molecular e usos da mesma |
| RU2606836C2 (ru) | 2015-03-12 | 2017-01-10 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Антикоагулянтный, антитромбоцитарный и фибриндеполимеризационный комплекс на основе гепарина, способ его получения и применение |
| WO2020216981A1 (es) * | 2019-04-26 | 2020-10-29 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento de obtención de heparinas de bajo peso molecular por filtración de flujo tangencial |
| MX2022009732A (es) | 2020-02-10 | 2022-09-09 | Univ Utah Res Found | Composiciones de heparina de alto peso molecular y metodos para diagnosticar, tratar y monitorear enfermedades inflamatorias mediadas por eosinofilos. |
-
2022
- 2022-05-12 BR BR112023022331A patent/BR112023022331A2/pt unknown
- 2022-05-12 JP JP2023570076A patent/JP2024518174A/ja active Pending
- 2022-05-12 MX MX2023013300A patent/MX2023013300A/es unknown
- 2022-05-12 EP EP22727649.0A patent/EP4326782A1/en active Pending
- 2022-05-12 CN CN202280034245.9A patent/CN117295772A/zh active Pending
- 2022-05-12 US US17/743,154 patent/US11712447B2/en active Active
- 2022-05-12 CA CA3217273A patent/CA3217273A1/en active Pending
- 2022-05-12 IL IL308411A patent/IL308411A/en unknown
- 2022-05-12 AU AU2022273722A patent/AU2022273722A1/en active Pending
- 2022-05-12 KR KR1020237042554A patent/KR20240006648A/ko unknown
- 2022-05-12 WO PCT/US2022/029014 patent/WO2022241130A1/en active Application Filing
-
2023
- 2023-06-12 US US18/333,057 patent/US20230321137A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230321137A1 (en) | 2023-10-12 |
| US20220362283A1 (en) | 2022-11-17 |
| BR112023022331A2 (pt) | 2023-12-26 |
| KR20240006648A (ko) | 2024-01-15 |
| JP2024518174A (ja) | 2024-04-25 |
| IL308411A (en) | 2024-01-01 |
| CN117295772A (zh) | 2023-12-26 |
| EP4326782A1 (en) | 2024-02-28 |
| CA3217273A1 (en) | 2022-11-17 |
| WO2022241130A1 (en) | 2022-11-17 |
| AU2022273722A1 (en) | 2023-11-02 |
| US11712447B2 (en) | 2023-08-01 |
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