MX2023012416A - Proceso de obtencion de rifapentina con una nueva forma cristalina. - Google Patents
Proceso de obtencion de rifapentina con una nueva forma cristalina.Info
- Publication number
- MX2023012416A MX2023012416A MX2023012416A MX2023012416A MX2023012416A MX 2023012416 A MX2023012416 A MX 2023012416A MX 2023012416 A MX2023012416 A MX 2023012416A MX 2023012416 A MX2023012416 A MX 2023012416A MX 2023012416 A MX2023012416 A MX 2023012416A
- Authority
- MX
- Mexico
- Prior art keywords
- rifapentine
- crystalline form
- obtaining
- new crystalline
- dimethylformamide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229960002599 rifapentine Drugs 0.000 title abstract 3
- WDZCUPBHRAEYDL-GZAUEHORSA-N rifapentine Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C(O)=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N(CC1)CCN1C1CCCC1 WDZCUPBHRAEYDL-GZAUEHORSA-N 0.000 title abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 2
- 229920002866 paraformaldehyde Polymers 0.000 abstract 2
- QYHRIASMJNLWHJ-UHFFFAOYSA-N 4-cyclopentylpiperazin-1-amine Chemical compound C1CN(N)CCN1C1CCCC1 QYHRIASMJNLWHJ-UHFFFAOYSA-N 0.000 abstract 1
- BTVYFIMKUHNOBZ-ZDHWWVNNSA-N Rifamycin S Natural products COC1C=COC2(C)Oc3c(C)c(O)c4C(=O)C(=CC(=O)c4c3C2=O)NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C BTVYFIMKUHNOBZ-ZDHWWVNNSA-N 0.000 abstract 1
- BTVYFIMKUHNOBZ-ODRIEIDWSA-N Rifamycin S Chemical compound O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC2=C3C1=O BTVYFIMKUHNOBZ-ODRIEIDWSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención proporciona una nueva forma cristalina de Rifapentina, su caracterización y el proceso de obtención de la misma. El proceso de obtención de la nueva forma cristalina comprende las etapas de adicionar una mezclar Dimetilformamida, tert-Butilamina y paraformaldehído a Rifamicina S en presencia de Ácido Acético glacial; agregar paraformaldehído y calentar; posteriormente agregar 1-Amino-4-ciclopentil piperazina en Dimetilformamida; agregar Ácido ascórbico en Agua y mezclar, filtrar y lavar el producto. El rendimiento de Rifapentina cruda es de 87+ 5% con una pureza del 99.00%.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MX2021/050020 WO2022225384A1 (es) | 2021-04-21 | 2021-04-21 | Proceso de obtención de rifapentina. con una nueva forma cristalina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023012416A true MX2023012416A (es) | 2024-03-05 |
Family
ID=83723045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023012416A MX2023012416A (es) | 2021-04-21 | 2021-04-21 | Proceso de obtencion de rifapentina con una nueva forma cristalina. |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20240199642A1 (es) |
| MX (1) | MX2023012416A (es) |
| WO (1) | WO2022225384A1 (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1478563A (en) * | 1975-03-05 | 1977-07-06 | Lepetit Spa | Rifamycin derivatives |
| GB8816620D0 (en) * | 1988-07-13 | 1988-08-17 | Lepetit Spa | Rifapentine hydrohalides |
| JP3350861B2 (ja) * | 1990-06-29 | 2002-11-25 | アベンテイス・バルク・ソチエタ・ペル・アチオニ | リファペンチンの純粋の結晶型 |
| CN103951677B (zh) * | 2014-03-17 | 2016-04-06 | 四川省长征药业股份有限公司 | 利福喷丁的制备方法 |
| CN111018886A (zh) * | 2019-12-20 | 2020-04-17 | 无锡福祈制药有限公司 | 一种高纯度利福喷丁的制备方法 |
-
2021
- 2021-04-21 MX MX2023012416A patent/MX2023012416A/es unknown
- 2021-04-21 WO PCT/MX2021/050020 patent/WO2022225384A1/es active Application Filing
- 2021-04-21 US US18/555,776 patent/US20240199642A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240199642A1 (en) | 2024-06-20 |
| WO2022225384A1 (es) | 2022-10-27 |
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