MX2023006456A - Nucleasas modificadas genéticamente optimizadas que tienen especificidad para el gen de la región constante alfa del receptor de linfocitos t humanos. - Google Patents

Nucleasas modificadas genéticamente optimizadas que tienen especificidad para el gen de la región constante alfa del receptor de linfocitos t humanos.

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Publication number
MX2023006456A
MX2023006456A MX2023006456A MX2023006456A MX2023006456A MX 2023006456 A MX2023006456 A MX 2023006456A MX 2023006456 A MX2023006456 A MX 2023006456A MX 2023006456 A MX2023006456 A MX 2023006456A MX 2023006456 A MX2023006456 A MX 2023006456A
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Mexico
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specificity
human
constant region
cell receptor
engineered nucleases
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MX2023006456A
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English (en)
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James Jefferson Smith
Hui Li
Janel Lape
Jochen Genschel
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Prec Biosciences Inc
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Publication of MX2023006456A publication Critical patent/MX2023006456A/es

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Abstract

La presente invención comprende nucleasas modificadas genéticamente que reconocen y escinden una secuencia de reconocimiento dentro del primer exón del gen de la región constante alfa del receptor de linfocitos T (TCR) humanos. Las meganucleasas modificadas genéticamente pueden presentar al menos una característica optimizada, tal como mayor (es decir, aumentada) especificidad o eficiencia de escisión, en comparación con la meganucleasa de primera generación TRC 1-2x87EE. La presente invención también comprende métodos para usar dichas nucleasas modificadas genéticamente para producir células modificadas genéticamente, y el uso de dichas células en una composición farmacéutica y en métodos para el tratamiento contra enfermedades, tales como cáncer.
MX2023006456A 2018-04-12 2020-10-12 Nucleasas modificadas genéticamente optimizadas que tienen especificidad para el gen de la región constante alfa del receptor de linfocitos t humanos. MX2023006456A (es)

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US201862656809P 2018-04-12 2018-04-12

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MX2023006456A MX2023006456A (es) 2018-04-12 2020-10-12 Nucleasas modificadas genéticamente optimizadas que tienen especificidad para el gen de la región constante alfa del receptor de linfocitos t humanos.

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JP (2) JP7304888B2 (es)
KR (2) KR102617818B1 (es)
CN (1) CN112218889A (es)
AU (2) AU2019252527B2 (es)
CA (1) CA3095795A1 (es)
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AU2024203244A1 (en) 2024-07-18
JP7304888B2 (ja) 2023-07-07
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CN112218889A (zh) 2021-01-12
US20210113616A1 (en) 2021-04-22
IL304025A (en) 2023-08-01
KR20200142037A (ko) 2020-12-21
EP4275697A2 (en) 2023-11-15
IL277883A (en) 2020-11-30
JP2021520800A (ja) 2021-08-26
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AU2019252527B2 (en) 2024-02-22
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US11786554B2 (en) 2023-10-17
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EP3774871B1 (en) 2023-06-28
US20240000845A1 (en) 2024-01-04
MX2020010795A (es) 2021-01-08
ES2955408T3 (es) 2023-11-30
WO2019200122A1 (en) 2019-10-17
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