MX2023006449A - Antianticuerpos gprc5d, moleculas de union al antigeno biespecificas que se unen a gprc5d y cd3, y usos de estas. - Google Patents

Antianticuerpos gprc5d, moleculas de union al antigeno biespecificas que se unen a gprc5d y cd3, y usos de estas.

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Publication number
MX2023006449A
MX2023006449A MX2023006449A MX2023006449A MX2023006449A MX 2023006449 A MX2023006449 A MX 2023006449A MX 2023006449 A MX2023006449 A MX 2023006449A MX 2023006449 A MX2023006449 A MX 2023006449A MX 2023006449 A MX2023006449 A MX 2023006449A
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Mexico
Prior art keywords
gprc5d
antibodies
antigen
binding fragments
antigen binding
Prior art date
Application number
MX2023006449A
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English (en)
Inventor
Alexey Teplyakov
Francois Gaudet
Yingzhe Li
Ricardo Attar
Mark Tornetta
Diana Chin
Suzanne Edavettal
Leopoldo Luistro
Nathan Majewski
Mark Mendonca
Kondandaram Pillarisetti
Original Assignee
Janssen Biotech Inc
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Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of MX2023006449A publication Critical patent/MX2023006449A/es

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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Abstract

En la presente invención, se proporcionan anticuerpos que se unen de manera específica a GPRC5D. Además, se describen los polinucleótidos relacionados capaces de codificar los anticuerpos específicos de GPRC5D o de unión al antígeno proporcionados, células que expresan los anticuerpos o fragmentos de unión al antígeno proporcionados, así como los vectores asociados y los anticuerpos o fragmentos de unión al antígeno marcados de forma detectable. Además, se describen los métodos para usar los anticuerpos proporcionados. Por ejemplo, los anticuerpos proporcionados podrían usarse para diagnosticar, tratar o monitorear la progresión, la regresión o la estabilidad del cáncer que expresa GPRC5D; para determinar si un paciente debe recibir o no tratamiento para cáncer; o para determinar si un sujeto sufre de un cáncer que expresa GPRC5D o no y, así, podría ser susceptible de tratamiento con un agente terapéutico anticáncer específico de GPRC5D, tal como los anticuerpos multiespecíficos contra GPRC5D y CD3 descritos en la presente descripción.
MX2023006449A 2016-07-20 2019-01-18 Antianticuerpos gprc5d, moleculas de union al antigeno biespecificas que se unen a gprc5d y cd3, y usos de estas. MX2023006449A (es)

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US201662364811P 2016-07-20 2016-07-20

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MX2023006449A true MX2023006449A (es) 2023-06-15

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MX2019000825A MX2019000825A (es) 2016-07-20 2017-07-20 Anticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de estas.
MX2023006449A MX2023006449A (es) 2016-07-20 2019-01-18 Antianticuerpos gprc5d, moleculas de union al antigeno biespecificas que se unen a gprc5d y cd3, y usos de estas.
MX2024001615A MX2024001615A (es) 2016-07-20 2019-01-18 Antianticuerpos gprc5d, moleculas de union al antigeno biespecificas que se unen a gprc5d y cd3, y usos de estas.

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US (4) US10562968B2 (es)
EP (1) EP3487882A2 (es)
JP (3) JP7292200B2 (es)
KR (2) KR102572091B1 (es)
CN (2) CN109715667B (es)
AR (1) AR109499A1 (es)
AU (2) AU2017299673B2 (es)
BR (1) BR112019001055A2 (es)
CA (1) CA3031472A1 (es)
CL (2) CL2019000146A1 (es)
CO (1) CO2019001114A2 (es)
CR (1) CR20190025A (es)
EA (1) EA201990346A1 (es)
EC (1) ECSP19012075A (es)
IL (2) IL298277A (es)
MA (1) MA45712A (es)
MX (3) MX2019000825A (es)
NI (1) NI201900005A (es)
PE (2) PE20240884A1 (es)
PH (1) PH12019500152A1 (es)
SG (1) SG11201900468YA (es)
TW (1) TWI781108B (es)
UY (1) UY37340A (es)
WO (1) WO2018017786A2 (es)
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