ECSP19012075A - Antianticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de estas - Google Patents

Antianticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de estas

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Publication number
ECSP19012075A
ECSP19012075A ECSENADI201912075A ECDI201912075A ECSP19012075A EC SP19012075 A ECSP19012075 A EC SP19012075A EC SENADI201912075 A ECSENADI201912075 A EC SENADI201912075A EC DI201912075 A ECDI201912075 A EC DI201912075A EC SP19012075 A ECSP19012075 A EC SP19012075A
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EC
Ecuador
Prior art keywords
gprc5d
antibodies
antigen
binding
cancer
Prior art date
Application number
ECSENADI201912075A
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English (en)
Inventor
Mark Mendonca
Leopoldo Luistro
Mark Tornetta
Francois Gaudet
Suzanne Edavettal
Diana Chin
Nathan Majewski
Ricardo Attar
Kodandaram Pillarisetti
Alexey Teplyakov
Gato S A S Promociones
Original Assignee
Janssen Pharmaceutica Nv
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ECSP19012075A publication Critical patent/ECSP19012075A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
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    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract

En la presente invención, se proporcionan anticuerpos que se unen de manera específica a GPRC5D. Además, se describen los polinucleótidos relacionados capaces de codificar los anticuerpos específicos de GPRC5D o de unión al antígeno proporcionados, células que expresan los anticuerpos o fragmentos de unión al antígeno proporcionados, así como los vectores asociados y los anticuerpos o fragmentos de unión al antígeno marcados de forma detectable. Además, se describen los métodos para usar los anticuerpos proporcionados. Por ejemplo, los anticuerpos proporcionados podrían usarse para diagnosticar, tratar o monitorear la progresión, la regresión o la estabilidad del cáncer que expresa GPRC5D; para determinar si un paciente debe recibir o no tratamiento para cáncer; o para determinar si un sujeto sufre de un cáncer que expresa GPRC5D o no y, así, podría ser susceptible de tratamiento con un agente terapéutico anticáncer específico de GPRC5D, tal como los anticuerpos multiespecíficos contra GPRC5D y CD3 descritos en la presente descripción.
ECSENADI201912075A 2016-07-20 2019-02-19 Antianticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de estas ECSP19012075A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662364811P 2016-07-20 2016-07-20

Publications (1)

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ECSP19012075A true ECSP19012075A (es) 2019-02-28

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ECSENADI201912075A ECSP19012075A (es) 2016-07-20 2019-02-19 Antianticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de estas

Country Status (25)

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US (3) US10562968B2 (es)
EP (1) EP3487882A2 (es)
JP (3) JP7292200B2 (es)
KR (2) KR20230128409A (es)
CN (2) CN109715667B (es)
AR (1) AR109499A1 (es)
AU (1) AU2017299673A1 (es)
BR (1) BR112019001055A2 (es)
CA (1) CA3031472A1 (es)
CL (1) CL2019000146A1 (es)
CO (1) CO2019001114A2 (es)
CR (1) CR20190025A (es)
EA (1) EA201990346A1 (es)
EC (1) ECSP19012075A (es)
IL (2) IL298277A (es)
MA (1) MA45712A (es)
MX (2) MX2019000825A (es)
NI (1) NI201900005A (es)
PE (2) PE20240884A1 (es)
PH (1) PH12019500152A1 (es)
SG (1) SG11201900468YA (es)
TW (1) TWI781108B (es)
UY (1) UY37340A (es)
WO (1) WO2018017786A2 (es)
ZA (1) ZA201901066B (es)

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