MX2023005917A - Metodo para purificar ester de sucralosa-6-etilo. - Google Patents

Metodo para purificar ester de sucralosa-6-etilo.

Info

Publication number
MX2023005917A
MX2023005917A MX2023005917A MX2023005917A MX2023005917A MX 2023005917 A MX2023005917 A MX 2023005917A MX 2023005917 A MX2023005917 A MX 2023005917A MX 2023005917 A MX2023005917 A MX 2023005917A MX 2023005917 A MX2023005917 A MX 2023005917A
Authority
MX
Mexico
Prior art keywords
ethyl ester
sucralose
polarity
crystallization
solvent
Prior art date
Application number
MX2023005917A
Other languages
English (en)
Inventor
Chuanjiu Xu
Chenggang Xu
Yongle Chen
Original Assignee
Anhui Jinhe Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anhui Jinhe Ind Co Ltd filed Critical Anhui Jinhe Ind Co Ltd
Publication of MX2023005917A publication Critical patent/MX2023005917A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/10—Process efficiency

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporciona un método para purificar éster de sucralosa-6-etilo, que incluye: preparación: proporcionar una disolución saturada de éster de sucralosa-6-etilo bruto en acetato de etilo que se calienta a una temperatura predeterminada; cristalización por gradiente: someter la disolución saturada a cristalización múltiple por enfriamiento y filtración, y recolectar el éster de sucralosa-6-butlilo bruto obtenido después de la cristalización múltiple por enfriamiento y filtración, donde durante cada proceso de cristalización por enfriamiento, se adiciona gota a gota un disolvente con baja polaridad a la disolución saturada para reducir la polaridad de la disolución saturada durante la cristalización paso a paso; y purificación: someter el éster de sucralosa-6-etilo bruto recolectado a recristalización para su purificación utilizando una disolución mixta de acetato de etilo y el disolvente con baja polaridad para obtener el éster de sucralosa-6-etilo fino de alta pureza. En la presente divulgación, el acetato de etilo se utiliza como un disolvente inicial para cristalización por enfriamiento del éster de sucralosa-6-etilo, y la polaridad del disolvente mixto se reduce adicionando paso a paso el disolvente con baja polaridad, lo cual mejora la eficacia de separación de impurezas en cada etapa del gradiente y conduce a un alto rendimiento y calidad del producto.
MX2023005917A 2020-11-27 2020-11-27 Metodo para purificar ester de sucralosa-6-etilo. MX2023005917A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2020/132262 WO2022110017A1 (zh) 2020-11-27 2020-11-27 一种三氯蔗糖-6-乙酯的纯化方法

Publications (1)

Publication Number Publication Date
MX2023005917A true MX2023005917A (es) 2023-05-24

Family

ID=75291169

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005917A MX2023005917A (es) 2020-11-27 2020-11-27 Metodo para purificar ester de sucralosa-6-etilo.

Country Status (4)

Country Link
EP (1) EP4215539A4 (es)
CN (1) CN112638924B (es)
MX (1) MX2023005917A (es)
WO (1) WO2022110017A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022233040A1 (zh) * 2021-05-07 2022-11-10 安徽金禾实业股份有限公司 一种三氯蔗糖-6-乙酯提纯方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1271077C (zh) * 2003-10-01 2006-08-23 常州市牛塘化工厂 三氯蔗糖－6－乙酯的制备方法
CN101328195B (zh) 2007-06-18 2011-01-05 盐城捷康三氯蔗糖制造有限公司 一种分离三氯蔗糖-6-酯的方法
CN101709069B (zh) 2009-08-06 2011-11-23 浙江工业大学 一种分离纯化三氯蔗糖-6-乙酯的新方法
CN102807594B (zh) * 2012-07-25 2015-05-13 湖北省宏源药业有限公司 一种三氯蔗糖-6-乙酯的精制方法
CN109956983B (zh) * 2017-12-25 2022-11-01 盐城捷康三氯蔗糖制造有限公司 三氯蔗糖-6-乙酯的提取方法
CN108250255A (zh) * 2018-01-24 2018-07-06 山东康宝生化科技有限公司 一种提高三氯蔗糖-6-乙酯结晶收率的方法
CN109734755A (zh) * 2018-12-28 2019-05-10 山东三和维信生物科技有限公司 一种三氯蔗糖结晶工艺
CN111000803A (zh) * 2019-12-03 2020-04-14 珠海亿邦制药有限责任公司 一种注射用克林霉素磷酸酯药物组合物的制备工艺

Also Published As

Publication number Publication date
CN112638924A (zh) 2021-04-09
CN112638924B (zh) 2022-12-20
EP4215539A4 (en) 2024-01-17
EP4215539A1 (en) 2023-07-26
WO2022110017A1 (zh) 2022-06-02

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