MX2023005387A - Cristales de maleato de forma-ii de (s)-n2-[1-(4-fluorofenil)etil] -4-(1-metil-1h-pirazol-4-il)-n6-(pirazin-2-il)piridina-2,6-diamin a. - Google Patents
Cristales de maleato de forma-ii de (s)-n2-[1-(4-fluorofenil)etil] -4-(1-metil-1h-pirazol-4-il)-n6-(pirazin-2-il)piridina-2,6-diamin a.Info
- Publication number
- MX2023005387A MX2023005387A MX2023005387A MX2023005387A MX2023005387A MX 2023005387 A MX2023005387 A MX 2023005387A MX 2023005387 A MX2023005387 A MX 2023005387A MX 2023005387 A MX2023005387 A MX 2023005387A MX 2023005387 A MX2023005387 A MX 2023005387A
- Authority
- MX
- Mexico
- Prior art keywords
- degrees
- sup
- compound
- cukî
- radiation
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 4
- 229940126062 Compound A Drugs 0.000 abstract 3
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 3
- 230000001747 exhibiting effect Effects 0.000 abstract 2
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 2
- 230000005855 radiation Effects 0.000 abstract 2
- 238000001228 spectrum Methods 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- VHNQIURBCCNWDN-UHFFFAOYSA-N pyridine-2,6-diamine Chemical compound NC1=CC=CC(N)=N1 VHNQIURBCCNWDN-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Un objeto principal de la presente invención es proporcionar nuevos cristales de (S)-N2-[1-(4-fluorofenil)etil]-4-(1-metil-1H-p irazol-4-il)-N6-(pirazin-2-il)piridina-2,6-diamina maleato (en lo sucesivo, referido como el "compuesto A"). Un cristal de Forma-I del compuesto A, que muestra picos de difracción en su espectro de difracción de polvo de rayos-X en al menos los siguientes ángulos de difracción 2?: 6.9 grados, 9.4 grados, 12.5 grados, 15.1 grados, 16.4 grados, 18.3 grados, 19.0 grados, 24.9 grados, 25.4 grados, 27.3 grados, y 27.7 grados, en donde espectro de difracción de polvo de rayos-X se obtiene al utilizar radiación Cu Ka (?=1.54Å). Un cristal de Forma-II del compuesto A, que muestra picos de difracción en su espectro de difracción de polvo de rayos-X en al menos los siguientes ángulos de difracción 2?: 6.9 grados, 9.2 grados, 12.4 grados, 14.8 grados, 16.5 grados, 18.1 grados, 18.5 grados, 19.8 grados, 23.6 grados, 24.9 grados, y 27.7 grados, en donde espectro de difracción de polvo de rayos-X se obtiene al utilizar radiación Cu Ka (?=1.54Å).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017187297 | 2017-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2023005387A true MX2023005387A (es) | 2023-05-23 |
Family
ID=65901897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007177A MX2020007177A (es) | 2017-09-28 | 2018-09-27 | Cristales. |
| MX2023005387A MX2023005387A (es) | 2017-09-28 | 2020-07-13 | Cristales de maleato de forma-ii de (s)-n2-[1-(4-fluorofenil)etil] -4-(1-metil-1h-pirazol-4-il)-n6-(pirazin-2-il)piridina-2,6-diamin a. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007177A MX2020007177A (es) | 2017-09-28 | 2018-09-27 | Cristales. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11680055B2 (es) |
| EP (1) | EP3689862A4 (es) |
| JP (2) | JPWO2019065793A1 (es) |
| KR (2) | KR20200060418A (es) |
| CN (2) | CN116874467A (es) |
| AU (2) | AU2018338857B2 (es) |
| BR (1) | BR112020005847A2 (es) |
| CA (1) | CA3076803A1 (es) |
| MX (2) | MX2020007177A (es) |
| PH (1) | PH12020550139A1 (es) |
| RU (1) | RU2020114659A (es) |
| WO (1) | WO2019065793A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022239068A1 (ja) * | 2021-05-10 | 2022-11-17 | 日本新薬株式会社 | サイトカインストーム抑制剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY155374A (en) | 2009-02-06 | 2015-10-15 | Nippon Shinyaku Co Ltd | Aminopyrazine derivative and medicine |
| JPWO2012005299A1 (ja) * | 2010-07-07 | 2013-09-05 | 日本新薬株式会社 | Ｒｏｓチロシンキナーゼ阻害剤 |
| WO2012020786A1 (ja) | 2010-08-11 | 2012-02-16 | 日本新薬株式会社 | 医薬組成物 |
| JP5668756B2 (ja) * | 2010-08-11 | 2015-02-12 | 日本新薬株式会社 | 悪性リンパ腫治療剤 |
-
2018
- 2018-09-27 CA CA3076803A patent/CA3076803A1/en active Pending
- 2018-09-27 AU AU2018338857A patent/AU2018338857B2/en active Active
- 2018-09-27 US US16/650,106 patent/US11680055B2/en active Active
- 2018-09-27 KR KR1020207010737A patent/KR20200060418A/ko active Application Filing
- 2018-09-27 KR KR1020237032969A patent/KR20230142814A/ko not_active Application Discontinuation
- 2018-09-27 WO PCT/JP2018/035830 patent/WO2019065793A1/ja unknown
- 2018-09-27 JP JP2019545595A patent/JPWO2019065793A1/ja active Pending
- 2018-09-27 MX MX2020007177A patent/MX2020007177A/es unknown
- 2018-09-27 EP EP18862238.5A patent/EP3689862A4/en active Pending
- 2018-09-27 RU RU2020114659A patent/RU2020114659A/ru unknown
- 2018-09-27 CN CN202310680580.2A patent/CN116874467A/zh active Pending
- 2018-09-27 CN CN201880062018.0A patent/CN111132971A/zh active Pending
- 2018-09-27 BR BR112020005847-5A patent/BR112020005847A2/pt unknown
-
2020
- 2020-03-26 PH PH12020550139A patent/PH12020550139A1/en unknown
- 2020-07-13 MX MX2023005387A patent/MX2023005387A/es unknown
-
2023
- 2023-06-07 AU AU2023203547A patent/AU2023203547A1/en active Pending
- 2023-06-07 JP JP2023093761A patent/JP2023105140A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3689862A1 (en) | 2020-08-05 |
| EP3689862A4 (en) | 2021-01-27 |
| JP2023105140A (ja) | 2023-07-28 |
| CN111132971A (zh) | 2020-05-08 |
| KR20200060418A (ko) | 2020-05-29 |
| CN116874467A (zh) | 2023-10-13 |
| JPWO2019065793A1 (ja) | 2020-10-22 |
| AU2023203547A1 (en) | 2023-07-06 |
| KR20230142814A (ko) | 2023-10-11 |
| RU2020114659A (ru) | 2021-10-28 |
| MX2020007177A (es) | 2020-10-14 |
| CA3076803A1 (en) | 2019-04-04 |
| RU2020114659A3 (es) | 2022-04-08 |
| WO2019065793A1 (ja) | 2019-04-04 |
| PH12020550139A1 (en) | 2020-12-07 |
| AU2018338857B2 (en) | 2023-05-25 |
| AU2018338857A1 (en) | 2020-04-16 |
| US11680055B2 (en) | 2023-06-20 |
| US20200223823A1 (en) | 2020-07-16 |
| BR112020005847A2 (pt) | 2020-09-29 |
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