EA202090398A1 - Фармацевтическая композиция, включающая сакубитрил и валсартан - Google Patents
Фармацевтическая композиция, включающая сакубитрил и валсартанInfo
- Publication number
- EA202090398A1 EA202090398A1 EA202090398A EA202090398A EA202090398A1 EA 202090398 A1 EA202090398 A1 EA 202090398A1 EA 202090398 A EA202090398 A EA 202090398A EA 202090398 A EA202090398 A EA 202090398A EA 202090398 A1 EA202090398 A1 EA 202090398A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical composition
- valsartan
- sakubitril
- relates
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Настоящее изобретение относится к фармацевтической композиции, включающей физическую смесь натриевой соли сакубитрила и динатриевой соли валсартана, где порошковая рентгеновская дифрактограмма динатриевой соли валсартана включает характеристические пики при следующих углах 2 тета (0,2): 4,70, 9,29, 22,34°, измеренные с использованием излучения Cu K. Настоящее изобретение также относится к применению указанной фармацевтической композиции в качестве лекарственного средства для лечения сердечной недостаточности.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17183859 | 2017-07-28 | ||
PCT/EP2018/070212 WO2019020706A1 (en) | 2017-07-28 | 2018-07-25 | PHARMACEUTICAL COMPOSITION COMPRISING SACUBITRIL AND VALSARTAN |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090398A1 true EA202090398A1 (ru) | 2020-05-15 |
Family
ID=59501295
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202090398A EA202090398A1 (ru) | 2017-07-28 | 2018-07-25 | Фармацевтическая композиция, включающая сакубитрил и валсартан |
Country Status (6)
Country | Link |
---|---|
US (1) | US10588892B2 (ru) |
EP (1) | EP3658122B1 (ru) |
EA (1) | EA202090398A1 (ru) |
ES (1) | ES2881317T3 (ru) |
PL (1) | PL3658122T3 (ru) |
WO (1) | WO2019020706A1 (ru) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018040065A1 (zh) * | 2016-09-02 | 2018-03-08 | 诺瑞特国际药业股份有限公司 | 缬沙坦二钠盐的晶型 |
EP4088715A1 (en) | 2021-05-14 | 2022-11-16 | KRKA, d.d., Novo mesto | Pharmaceutical formulation of valsartan and sacubitril |
WO2023211412A1 (en) * | 2022-04-26 | 2023-11-02 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | A tablet comprising sacubitril and valsartan processed with dry granulation |
EP4268806A3 (en) * | 2022-04-26 | 2023-12-27 | Sanovel Ilac Sanayi Ve Ticaret A.S. | A tablet comprising sacubitril and valsartan processed with dry granulation |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE134624T1 (de) | 1990-02-19 | 1996-03-15 | Ciba Geigy Ag | Acylverbindungen |
WO1992013564A1 (en) | 1991-02-06 | 1992-08-20 | Schering Corporation | Combination of an angiotensin ii antagonist or renin inhibitor with a neutral endopeptidase inhibitor |
US5217996A (en) | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
CA2168066A1 (en) | 1995-02-08 | 1996-08-09 | James R. Powell | Treatment of hypertension and congestive heart failure |
US6204281B1 (en) | 1998-07-10 | 2001-03-20 | Novartis Ag | Method of treatment and pharmaceutical composition |
AR032758A1 (es) | 2000-07-19 | 2003-11-26 | Novartis Ag | Sales valsartan, un proceso para su fabricacion, composiciones farmaceuticas y el uso de dichas sales para la preparacion de medicamentos |
US7468390B2 (en) | 2002-01-17 | 2008-12-23 | Novartis Ag | Methods of treatment and pharmaceutical composition |
BR122018015003B8 (pt) | 2002-01-17 | 2021-07-27 | Novartis Ag | kit compreendendo composições farmacêuticas de inibidor da nep e de valsartan ou seus sais |
AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
CA2703598C (en) | 2007-11-06 | 2016-08-09 | Novartis Ag | Dual-acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor |
WO2013181455A1 (en) * | 2012-05-30 | 2013-12-05 | Robert Gellibolian | Water bottle with flow meter |
CN105837464A (zh) | 2015-01-15 | 2016-08-10 | 四川海思科制药有限公司 | 沙库比曲钠的晶型及其制备方法和用途 |
KR20200117037A (ko) * | 2015-06-12 | 2020-10-13 | 테바 파마슈티컬스 인터내셔널 게엠베하 | 삼나트륨 발사르탄:사쿠비트릴의 고체 형태 |
WO2017012600A1 (en) | 2015-07-20 | 2017-01-26 | Zentiva, K.S. | A pharmaceutical composition containing valsartan and sacubitril and methods for preparation and stabilization thereof |
EP3386945A1 (en) * | 2015-12-11 | 2018-10-17 | Zentiva, K.S. | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
US10722471B2 (en) * | 2016-02-03 | 2020-07-28 | Novartis Ag | Galenic formulations of organic compounds |
-
2018
- 2018-07-25 EP EP18759256.3A patent/EP3658122B1/en active Active
- 2018-07-25 EA EA202090398A patent/EA202090398A1/ru unknown
- 2018-07-25 WO PCT/EP2018/070212 patent/WO2019020706A1/en active Application Filing
- 2018-07-25 PL PL18759256T patent/PL3658122T3/pl unknown
- 2018-07-25 ES ES18759256T patent/ES2881317T3/es active Active
- 2018-07-26 US US16/046,531 patent/US10588892B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3658122B1 (en) | 2021-04-07 |
EP3658122A1 (en) | 2020-06-03 |
PL3658122T3 (pl) | 2021-10-18 |
US20190030000A1 (en) | 2019-01-31 |
WO2019020706A1 (en) | 2019-01-31 |
ES2881317T3 (es) | 2021-11-29 |
US10588892B2 (en) | 2020-03-17 |
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