MX2020011818A - Derivados de piridincarboxamida, su metodo de preparacion y sus usos farmaceuticos. - Google Patents
Derivados de piridincarboxamida, su metodo de preparacion y sus usos farmaceuticos.Info
- Publication number
- MX2020011818A MX2020011818A MX2020011818A MX2020011818A MX2020011818A MX 2020011818 A MX2020011818 A MX 2020011818A MX 2020011818 A MX2020011818 A MX 2020011818A MX 2020011818 A MX2020011818 A MX 2020011818A MX 2020011818 A MX2020011818 A MX 2020011818A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- method therefor
- derivatives
- pyridinecarboxamide derivatives
- pharmaceutical uses
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con los derivados de piridincarboxamida, un método de preparación de los mismos y uso farmacéutico de los mismos. De manera específica, la presente invención se relaciona con derivados de piridincarboxamida representados por la fórmula general (I), en donde los sustituyentes de la fórmula (I) se definen como el mismo que en la descripción, un método de preparación del mismo, una composición farmacéutica que comprende los derivados, y los usos como activos terapéuticos, especialmente como inhibidores del conducto de potasio medular de la franja exterior de los riñones (ROMK) y en la preparación de medicamentos para tratar y/o prevenir la hipertensión e insuficiencia cardiaca. (ver Fórmula).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410741280 | 2014-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020011818A true MX2020011818A (es) | 2021-01-15 |
Family
ID=56106663
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017006536A MX2017006536A (es) | 2014-12-08 | 2015-11-10 | Derivados de piridincarboxamida, su metodo de preparacion y sus usos farmaceuticos. |
| MX2020011818A MX2020011818A (es) | 2014-12-08 | 2017-05-18 | Derivados de piridincarboxamida, su metodo de preparacion y sus usos farmaceuticos. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017006536A MX2017006536A (es) | 2014-12-08 | 2015-11-10 | Derivados de piridincarboxamida, su metodo de preparacion y sus usos farmaceuticos. |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US10364234B2 (es) |
| EP (1) | EP3231802B1 (es) |
| JP (1) | JP6736816B2 (es) |
| KR (1) | KR20170090477A (es) |
| CN (1) | CN105980379B (es) |
| AU (1) | AU2015361614B2 (es) |
| BR (1) | BR112017010645A2 (es) |
| CA (1) | CA2966788A1 (es) |
| MX (2) | MX2017006536A (es) |
| RU (1) | RU2694899C9 (es) |
| TW (1) | TWI718113B (es) |
| WO (1) | WO2016091042A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3445762B1 (en) | 2016-04-20 | 2023-09-13 | Bristol-Myers Squibb Company | Substituted bicyclic heterocyclic compounds |
| TW201742866A (zh) * | 2016-06-07 | 2017-12-16 | 江蘇恆瑞醫藥股份有限公司 | 一種腎外髓質分泌鉀通道抑制劑的可藥用鹽 |
| CN106432071B (zh) * | 2016-09-05 | 2019-04-02 | 河北正朗制药有限公司 | 5-氰基-4-甲氧基-2-吡啶甲酸的盐酸盐的制备及其应用 |
| US10723723B2 (en) | 2016-11-03 | 2020-07-28 | Bristol-Myers Squibb Company | Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors |
| CN108113988A (zh) * | 2016-11-29 | 2018-06-05 | 江苏恒瑞医药股份有限公司 | 一种romk抑制剂与arb联合在制备治疗和/或预防高血压或心力衰竭的药物中的用途 |
| WO2018222795A1 (en) | 2017-06-01 | 2018-12-06 | Bristol-Myers Squibb Company | Substituted nitrogen containing compounds |
| WO2019011200A1 (zh) * | 2017-07-10 | 2019-01-17 | 江苏恒瑞医药股份有限公司 | 一种吡啶甲酰胺类衍生物的制备方法及其中间体 |
| CN109879863B (zh) * | 2017-12-06 | 2020-10-20 | 江苏恒瑞医药股份有限公司 | 一种肾外髓质分泌钾通道抑制剂的晶型及其制备方法 |
| BR112020011161A2 (pt) * | 2017-12-06 | 2020-11-17 | Jiangsu Hengrui Medicine Co., Ltd. | forma cristalina de um inibidor de canal medular renal externo, composição farmacêutica que a compreende, método de preparação da referida forma cristalina e composição farmacêutica e uso das mesmas |
| WO2020173476A1 (zh) * | 2019-02-28 | 2020-09-03 | 江苏恒瑞医药股份有限公司 | 一种含有肾脏钾离子外排通道抑制剂的药物组合物及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8119809B2 (en) * | 2007-11-16 | 2012-02-21 | Rigel Pharmaceuticals, Inc. | AMPK-activating heterocycloalkyloxy(hetero)aryl carboxamide, sulfonamide and amine compounds and methods for using the same |
| US8673920B2 (en) * | 2009-05-06 | 2014-03-18 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2012058116A1 (en) | 2010-10-27 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2012058134A1 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9062070B2 (en) * | 2011-08-19 | 2015-06-23 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| US9527830B2 (en) | 2011-09-16 | 2016-12-27 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2013062892A1 (en) | 2011-10-25 | 2013-05-02 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| EP2773199B1 (en) | 2011-10-31 | 2019-04-10 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| WO2014015495A1 (en) | 2012-07-26 | 2014-01-30 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
| AR092031A1 (es) * | 2012-07-26 | 2015-03-18 | Merck Sharp & Dohme | Inhibidores del canal de potasio medular externo renal |
| US9777002B2 (en) * | 2012-11-29 | 2017-10-03 | Merck Sharp & Dohme Corp. | Inhibitors of the renal outer medullary potassium channel |
-
2015
- 2015-11-10 JP JP2017528783A patent/JP6736816B2/ja not_active Expired - Fee Related
- 2015-11-10 RU RU2017121460A patent/RU2694899C9/ru active
- 2015-11-10 MX MX2017006536A patent/MX2017006536A/es unknown
- 2015-11-10 KR KR1020177018177A patent/KR20170090477A/ko not_active Application Discontinuation
- 2015-11-10 AU AU2015361614A patent/AU2015361614B2/en not_active Ceased
- 2015-11-10 BR BR112017010645A patent/BR112017010645A2/pt not_active IP Right Cessation
- 2015-11-10 US US15/531,525 patent/US10364234B2/en not_active Expired - Fee Related
- 2015-11-10 WO PCT/CN2015/094164 patent/WO2016091042A1/zh active Application Filing
- 2015-11-10 CA CA2966788A patent/CA2966788A1/en not_active Abandoned
- 2015-11-10 EP EP15868279.9A patent/EP3231802B1/en active Active
- 2015-11-10 CN CN201580008517.8A patent/CN105980379B/zh active Active
- 2015-12-03 TW TW104140503A patent/TWI718113B/zh active
-
2017
- 2017-05-18 MX MX2020011818A patent/MX2020011818A/es unknown
-
2019
- 2019-01-25 US US16/257,484 patent/US10759788B2/en active Active
- 2019-01-25 US US16/257,716 patent/US10442794B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017121460A3 (es) | 2019-03-28 |
| EP3231802A4 (en) | 2018-05-02 |
| AU2015361614A1 (en) | 2017-06-22 |
| TW201620898A (zh) | 2016-06-16 |
| EP3231802A1 (en) | 2017-10-18 |
| AU2015361614B2 (en) | 2019-11-28 |
| CN105980379A (zh) | 2016-09-28 |
| EP3231802B1 (en) | 2021-05-05 |
| CN105980379B (zh) | 2018-09-07 |
| US10759788B2 (en) | 2020-09-01 |
| US20170342059A1 (en) | 2017-11-30 |
| JP6736816B2 (ja) | 2020-08-05 |
| JP2017536383A (ja) | 2017-12-07 |
| US20190152959A1 (en) | 2019-05-23 |
| US10442794B2 (en) | 2019-10-15 |
| TWI718113B (zh) | 2021-02-11 |
| WO2016091042A1 (zh) | 2016-06-16 |
| KR20170090477A (ko) | 2017-08-07 |
| CA2966788A1 (en) | 2016-06-16 |
| US10364234B2 (en) | 2019-07-30 |
| US20190152958A1 (en) | 2019-05-23 |
| RU2017121460A (ru) | 2019-01-10 |
| RU2694899C2 (ru) | 2019-07-18 |
| RU2694899C9 (ru) | 2019-08-28 |
| MX2017006536A (es) | 2017-08-09 |
| BR112017010645A2 (pt) | 2017-12-26 |
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