MX2023000936A - Proceso para preparar un compuesto de isoxazolina e intermedio del mismo. - Google Patents

Proceso para preparar un compuesto de isoxazolina e intermedio del mismo.

Info

Publication number
MX2023000936A
MX2023000936A MX2023000936A MX2023000936A MX2023000936A MX 2023000936 A MX2023000936 A MX 2023000936A MX 2023000936 A MX2023000936 A MX 2023000936A MX 2023000936 A MX2023000936 A MX 2023000936A MX 2023000936 A MX2023000936 A MX 2023000936A
Authority
MX
Mexico
Prior art keywords
making
isoxazoline compound
formula
present disclosure
enantiomerically pure
Prior art date
Application number
MX2023000936A
Other languages
English (en)
Inventor
Jean Marie Defauw
Ping Huang
Jing Chen
Jingdan Hu
Guanmin Wu
Xin Zhang
Original Assignee
Elanco Us Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2020/104035 external-priority patent/WO2022016490A1/en
Application filed by Elanco Us Inc filed Critical Elanco Us Inc
Publication of MX2023000936A publication Critical patent/MX2023000936A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente divulgación proporciona procesos para hacer compuestos de isoxazolina enantioméricamente puros de la fórmula (1), (ver Fórmula) (1). La presente divulgación también proporciona procesos para hacer compuestos de isoxazolina enantioméricamente puros de la fórmula (1) caracterizados por mejorar la pureza enantiomérica del ácido 3-metil-5-[(5S)-5-(3,4,5 -triclorofenil)-5-(trifluorometil)-4H-isoxazol-3-il]tiofeno-2-car boxílico mediante cristalización.
MX2023000936A 2020-07-24 2021-07-22 Proceso para preparar un compuesto de isoxazolina e intermedio del mismo. MX2023000936A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063055923P 2020-07-24 2020-07-24
PCT/CN2020/104035 WO2022016490A1 (en) 2020-07-24 2020-07-24 Process for lotilaner intermediate
PCT/US2021/042769 WO2022020585A1 (en) 2020-07-24 2021-07-22 Process for making an isoxazoline compound and intermediate thereof

Publications (1)

Publication Number Publication Date
MX2023000936A true MX2023000936A (es) 2023-02-22

Family

ID=77338881

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023000936A MX2023000936A (es) 2020-07-24 2021-07-22 Proceso para preparar un compuesto de isoxazolina e intermedio del mismo.

Country Status (10)

Country Link
US (1) US20230257370A1 (es)
EP (1) EP4185585A1 (es)
JP (1) JP2023536070A (es)
KR (1) KR20230043904A (es)
CN (1) CN116194450A (es)
AU (1) AU2021311722A1 (es)
CA (1) CA3185969A1 (es)
MX (1) MX2023000936A (es)
TW (1) TW202212336A (es)
WO (1) WO2022020585A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115594645B (zh) * 2022-11-08 2023-04-14 山东亚华生物科技有限公司 一种氟雷拉纳的合成方法
CN115504971B (zh) * 2022-11-09 2023-03-28 世华合创生物技术开发(山东)有限公司 一种洛替拉纳的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ593135A (en) 2008-12-19 2013-04-26 Novartis Ag Isoxazoline derivatives and their use as pesticide
BR112012020983A2 (pt) 2010-02-25 2016-11-01 Syngenta Ltd processo para a preparação de derivados isoxazolina
US9126995B2 (en) 2011-11-08 2015-09-08 Nissan Chemical Industries, Ltd. Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
AU2012344083A1 (en) 2011-11-29 2014-05-29 Novartis Tiergesundheit Ag Aryl derivatives for controlling ectoparasites
WO2013116236A1 (en) 2012-02-03 2013-08-08 Zoetis Llc Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents
ES2916805T3 (es) 2012-11-21 2022-07-06 Zoetis Services Llc Síntesis de derivados de isoxazolina espirocíclicos
WO2014090918A1 (en) 2012-12-13 2014-06-19 Novartis Ag Process for the enantiomeric enrichment of diaryloxazoline derivatives
KR102403531B1 (ko) 2016-04-06 2022-05-27 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 거울상 이성질체적으로 풍부한 이속사졸린 화합물의 제조 방법 및 (s)-아폭솔라너의 결정질 톨루엔 용매화물
CN109328017A (zh) * 2016-05-10 2019-02-12 瑞士伊兰科动物保健有限公司 用于控制海虱的二氢异噁唑化合物

Also Published As

Publication number Publication date
KR20230043904A (ko) 2023-03-31
AU2021311722A1 (en) 2023-02-02
US20230257370A1 (en) 2023-08-17
JP2023536070A (ja) 2023-08-23
CA3185969A1 (en) 2022-01-27
CN116194450A (zh) 2023-05-30
WO2022020585A1 (en) 2022-01-27
TW202212336A (zh) 2022-04-01
EP4185585A1 (en) 2023-05-31

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