MX2022008099A - Tratamiento para el cancer con inhibidores de cdk12/13. - Google Patents

Tratamiento para el cancer con inhibidores de cdk12/13.

Info

Publication number
MX2022008099A
MX2022008099A MX2022008099A MX2022008099A MX2022008099A MX 2022008099 A MX2022008099 A MX 2022008099A MX 2022008099 A MX2022008099 A MX 2022008099A MX 2022008099 A MX2022008099 A MX 2022008099A MX 2022008099 A MX2022008099 A MX 2022008099A
Authority
MX
Mexico
Prior art keywords
cancer
cdk12
inhibitors
treatment
compositions
Prior art date
Application number
MX2022008099A
Other languages
English (en)
Inventor
Elisabeth Gardiner
Eric A Murphy
Toufike Kanouni
Eric Martin
John Tyhonas
Lee D Arnold
Noelito Timple
Original Assignee
Kinnate Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinnate Biopharma Inc filed Critical Kinnate Biopharma Inc
Publication of MX2022008099A publication Critical patent/MX2022008099A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En el presente documento se proporcionan composiciones y métodos para el tratamiento de cáncer de mama triple negativo, cáncer de ovario y cáncer de próstata resistente a la castración. Dichas composiciones comprenden inhibidores de CDK12/13.
MX2022008099A 2019-12-31 2020-12-23 Tratamiento para el cancer con inhibidores de cdk12/13. MX2022008099A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962956114P 2019-12-31 2019-12-31
PCT/US2020/066967 WO2021138215A1 (en) 2019-12-31 2020-12-23 Treatment of cancer with cdk12/13 inhibitors

Publications (1)

Publication Number Publication Date
MX2022008099A true MX2022008099A (es) 2022-07-11

Family

ID=76686778

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022008099A MX2022008099A (es) 2019-12-31 2020-12-23 Tratamiento para el cancer con inhibidores de cdk12/13.

Country Status (11)

Country Link
US (1) US20230074545A1 (es)
EP (1) EP4085053A4 (es)
JP (1) JP2023508996A (es)
KR (1) KR20220123064A (es)
CN (1) CN115175899A (es)
AU (1) AU2020417223A1 (es)
BR (1) BR112022012867A2 (es)
CA (1) CA3166386A1 (es)
IL (1) IL294392A (es)
MX (1) MX2022008099A (es)
WO (1) WO2021138215A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11447493B2 (en) 2018-05-02 2022-09-20 Kinnate Biopharma Inc. Inhibitors of cyclin-dependent kinases
EP3813819A4 (en) 2018-06-29 2022-08-17 Kinnate Biopharma Inc. CYCLIN-DEPENDENT KINASE INHIBITORS
WO2023102184A1 (en) * 2021-12-03 2023-06-08 Incyte Corporation Bicyclic amine compounds as cdk12 inhibitors
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors
AU2023320623A1 (en) * 2022-08-08 2025-02-20 Insilico Medicine Ip Limited Inhibitors of cyclin-dependent kinase (cdk) 12 and/or cdk13 and uses thereof
EP4671239A1 (en) * 2023-02-24 2025-12-31 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences DEGRADING AGENT CONTAINING AN ARYL SUBSTITUTE FOR CDK12/13, ITS PREPARATION PROCESS, PHARMACEUTICAL COMPOSITION AND ITS USE

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7732491B2 (en) * 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
MX374075B (es) * 2010-03-26 2025-03-05 Dartmouth College Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos.
US9125899B1 (en) * 2010-06-17 2015-09-08 Stc.Unm Modulators of GTPases and their use
PL2945628T3 (pl) * 2013-01-15 2020-09-21 Aragon Pharmaceuticals, Inc. Modulator receptorów androgenowych w skojarzeniu z octanem abirateronu i prednizonem do leczenia nowotworu stercza
CA2927924A1 (en) * 2013-10-18 2015-04-23 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of proliferative diseases
PT3386997T (pt) * 2015-12-09 2021-11-04 Univ Wien Med Compostos de platina com funções de mono-maleimida para a terapêutica do cancro
SG11201811564QA (en) * 2016-06-29 2019-01-30 Tesaro Inc Methods of treating ovarian cancer
US11447493B2 (en) * 2018-05-02 2022-09-20 Kinnate Biopharma Inc. Inhibitors of cyclin-dependent kinases
EP3813819A4 (en) * 2018-06-29 2022-08-17 Kinnate Biopharma Inc. CYCLIN-DEPENDENT KINASE INHIBITORS
TWI719765B (zh) * 2018-12-19 2021-02-21 美商建南德克公司 使用包含akt抑制劑、紫杉烷及pd-l1抑制劑之組合療法之乳癌治療

Also Published As

Publication number Publication date
BR112022012867A2 (pt) 2022-09-06
KR20220123064A (ko) 2022-09-05
JP2023508996A (ja) 2023-03-06
EP4085053A4 (en) 2023-12-27
IL294392A (en) 2022-08-01
AU2020417223A1 (en) 2022-07-14
US20230074545A1 (en) 2023-03-09
CA3166386A1 (en) 2021-07-08
WO2021138215A1 (en) 2021-07-08
CN115175899A (zh) 2022-10-11
EP4085053A1 (en) 2022-11-09

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