MX2018011875A - Reprogramacion cardiaca directa mejorada. - Google Patents

Reprogramacion cardiaca directa mejorada.

Info

Publication number
MX2018011875A
MX2018011875A MX2018011875A MX2018011875A MX2018011875A MX 2018011875 A MX2018011875 A MX 2018011875A MX 2018011875 A MX2018011875 A MX 2018011875A MX 2018011875 A MX2018011875 A MX 2018011875A MX 2018011875 A MX2018011875 A MX 2018011875A
Authority
MX
Mexico
Prior art keywords
direct cardiac
enhanced direct
cardiac reprogramming
present disclosure
provides methods
Prior art date
Application number
MX2018011875A
Other languages
English (en)
Inventor
Srivastava Deepak
Mohamed Tamer
Original Assignee
The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone filed Critical The J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone
Publication of MX2018011875A publication Critical patent/MX2018011875A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

La presente descripcion provee metodos para generar cardiomiocitos inducidos; la presente descripcion provee ademas metodos y composiciones para tratar la enfermedad cardiovascular.
MX2018011875A 2016-03-30 2017-03-30 Reprogramacion cardiaca directa mejorada. MX2018011875A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662315437P 2016-03-30 2016-03-30
US201662370344P 2016-08-03 2016-08-03
PCT/US2017/025132 WO2017173137A1 (en) 2016-03-30 2017-03-30 Enhanced direct cardiac reprogramming

Publications (1)

Publication Number Publication Date
MX2018011875A true MX2018011875A (es) 2019-03-28

Family

ID=59966473

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018011875A MX2018011875A (es) 2016-03-30 2017-03-30 Reprogramacion cardiaca directa mejorada.

Country Status (9)

Country Link
US (1) US20200297775A1 (es)
EP (1) EP3436569A4 (es)
JP (1) JP2019513366A (es)
KR (1) KR20190037195A (es)
AU (1) AU2017244205A1 (es)
BR (1) BR112018070255A2 (es)
CA (1) CA3019570A1 (es)
MX (1) MX2018011875A (es)
WO (1) WO2017173137A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3758720A4 (en) * 2018-03-01 2022-03-23 Georgia Tech Research Corporation METHODS AND COMPOSITIONS FOR MRNA-BASED MODULATION AND DETECTION OF CELL PHENOTYPES
US11399803B2 (en) * 2018-08-08 2022-08-02 General Electric Company Ultrasound imaging system and method
KR20210102870A (ko) 2018-08-30 2021-08-20 테나야 테라퓨틱스, 인코포레이티드 미오카르딘 및 ascl1을 사용한 심장 세포 재프로그래밍
CN114615985A (zh) * 2019-09-11 2022-06-10 西奈山伊坎医学院 包含修饰mRNA的分子的组合物及其使用方法
CN116249768A (zh) * 2020-07-29 2023-06-09 南京昕瑞再生医药科技有限公司 通过重编程产生心肌细胞的方法
WO2023201207A1 (en) 2022-04-11 2023-10-19 Tenaya Therapeutics, Inc. Adeno-associated virus with engineered capsid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006109170A2 (en) * 2005-04-14 2006-10-19 Esperion Therapeutics Inc. Combination therapy for treatment of cardiovascular diseases and related conditions
WO2010007031A2 (en) * 2008-07-14 2010-01-21 Novartis Ag Methods for improving cardiac differentiation of human embryonic stem cells
JP5988961B2 (ja) * 2010-04-28 2016-09-07 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ 心筋細胞を発生させるための方法
EP2660314A4 (en) * 2010-12-27 2014-09-03 Lsip Llc IPS CELLS AND METHOD FOR THEIR PRODUCTION

Also Published As

Publication number Publication date
CA3019570A1 (en) 2017-10-05
AU2017244205A1 (en) 2018-10-25
US20200297775A1 (en) 2020-09-24
BR112018070255A2 (pt) 2019-01-29
JP2019513366A (ja) 2019-05-30
WO2017173137A1 (en) 2017-10-05
KR20190037195A (ko) 2019-04-05
EP3436569A1 (en) 2019-02-06
EP3436569A4 (en) 2019-11-13

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