MX2022002547A - Una nueva plataforma de virus oncoliticos para tratar canceres con virus myxoma. - Google Patents

Una nueva plataforma de virus oncoliticos para tratar canceres con virus myxoma.

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Publication number
MX2022002547A
MX2022002547A MX2022002547A MX2022002547A MX2022002547A MX 2022002547 A MX2022002547 A MX 2022002547A MX 2022002547 A MX2022002547 A MX 2022002547A MX 2022002547 A MX2022002547 A MX 2022002547A MX 2022002547 A MX2022002547 A MX 2022002547A
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Mexico
Prior art keywords
myxvs
virus
platform
treat cancers
myxoma
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MX2022002547A
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English (en)
Inventor
Mohammed Masmudur Rahman
Lino Torres-Dominguez
Nancy Villa
Douglas Grant Mcfadden
Achury Lina Franco
Leslie Lynne Sharp
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Univ Arizona State
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Publication of MX2022002547A publication Critical patent/MX2022002547A/es

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Abstract

Se divulga en este documento, en ciertas modalidades, virus Myxoma recombinantes (MYXV) y construcciones de ácido nucleico que codifican los MYXV recombinantes. En algunas modalidades, los MYXV son diseñados para inactivar o atenuar una actividad o nivel de expresión de una proteína M153. En algunas modalidades, los MYXV están diseñados para expresar uno o más transgenes tales como un factor de necrosis tumoral (TNF), interleucina 12 (IL-12) o decorina. También se divulga en este documento, en ciertas modalidades, métodos de uso de los MYXV. Algunas modalidades incluyen provee un MYXV como se describe en este documento a un sujeto en necesidad del mismo.
MX2022002547A 2019-09-02 2020-09-02 Una nueva plataforma de virus oncoliticos para tratar canceres con virus myxoma. MX2022002547A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962894925P 2019-09-02 2019-09-02
US201962944233P 2019-12-05 2019-12-05
PCT/US2020/049061 WO2021046125A1 (en) 2019-09-02 2020-09-02 A new oncolytic virus platform to treat cancers with myxoma virus

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MX2022002547A true MX2022002547A (es) 2022-05-18

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US (3) US11117934B2 (es)
EP (1) EP4025228A4 (es)
JP (1) JP2022546539A (es)
KR (1) KR20220112241A (es)
CN (1) CN114615988A (es)
AU (1) AU2020342510A1 (es)
CA (1) CA3152779A1 (es)
IL (1) IL291009A (es)
MX (1) MX2022002547A (es)
TW (1) TW202122411A (es)
WO (1) WO2021046125A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021002668A (es) * 2018-09-05 2021-05-12 Univ Arizona State Plataforma de virus oncolitico para tratar el cancer hematologico.
JP2022546539A (ja) 2019-09-02 2022-11-04 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 粘液腫ウイルスを用いて癌を治療するための新しい腫瘍崩壊ウイルスプラットフォーム
JP2024508920A (ja) * 2021-03-01 2024-02-28 オンコミクス セラピューティクス，インク． 多武装の粘液腫ウイルス

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ES2153284B1 (es) 1998-06-10 2001-09-01 Fundacion Para El Estudio Y De Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.
WO2007143545A2 (en) * 2006-06-01 2007-12-13 Robarts Research Institute Tnf signaling in myxoma virus treatments
FR2946536B1 (fr) * 2009-06-11 2011-07-29 Agronomique Inst Nat Rech Utilisation d'une souche attenuee de myxoma virus comme oncolytique
EP2576581A4 (en) * 2010-06-06 2015-04-15 Sinai School Medicine RECOMBINANT RNA VIRUSES AND USES THEREOF
CN114262690A (zh) * 2011-04-15 2022-04-01 吉恩勒克斯公司 减毒的痘苗病毒的克隆毒株及其使用方法
PT2717887T (pt) 2011-06-09 2018-04-04 Univ Florida Métodos para tratamento ou prevenção da doença do enxerto contra hospedeiro
JP6641276B2 (ja) 2013-11-28 2020-02-05 バヴァリアン・ノルディック・アクティーゼルスカブ ポックスウイルスベクターを用いて増強された免疫応答を誘導するための組成物及び方法ベクター
CN108025056B (zh) * 2015-06-19 2022-01-14 新罗杰股份有限公司 用于病毒栓塞的组合物和方法
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JP2019527737A (ja) * 2016-08-09 2019-10-03 アルケヤール， アルモハナッドＡＬＫＡＹＹＡＬ， Ａｌｍｏｈａｎａｄ Ｉｌ１２を発現する腫瘍溶解性ラブドウイルス
EP3820491A4 (en) * 2018-07-13 2022-07-13 Arizona Board of Regents on behalf of Arizona State University METHODS OF TREATING CANCER WITH A TNF-EXPRESSING MYXOMA VIRUS
CA3109216A1 (en) 2018-08-16 2020-02-20 Musc Foundation For Research Development Recombinant myxoma viruses and uses thereof
MX2021002668A (es) 2018-09-05 2021-05-12 Univ Arizona State Plataforma de virus oncolitico para tratar el cancer hematologico.
WO2020198690A1 (en) 2019-03-28 2020-10-01 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Oncolytic myxoma virus expressing fast p14 to treat hematological cancer
JP2022546539A (ja) 2019-09-02 2022-11-04 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 粘液腫ウイルスを用いて癌を治療するための新しい腫瘍崩壊ウイルスプラットフォーム
AU2020340934A1 (en) 2019-09-02 2022-03-31 Arizona Board Of Regents On Behalf Of Arizona State University Methods and compositions for improving oncolytic virus infection for nonpermissive cancers

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WO2021046125A1 (en) 2021-03-11
US20230025706A1 (en) 2023-01-26
US20210324014A1 (en) 2021-10-21
TW202122411A (zh) 2021-06-16
CN114615988A (zh) 2022-06-10
EP4025228A4 (en) 2023-09-06
US20210061864A1 (en) 2021-03-04
US11117934B2 (en) 2021-09-14
EP4025228A1 (en) 2022-07-13
JP2022546539A (ja) 2022-11-04
CA3152779A1 (en) 2021-03-11
KR20220112241A (ko) 2022-08-10
IL291009A (en) 2022-05-01
AU2020342510A1 (en) 2022-03-24

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