ES2153284B1 - Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos. - Google Patents

Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.

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Publication number
ES2153284B1
ES2153284B1 ES009801219A ES9801219A ES2153284B1 ES 2153284 B1 ES2153284 B1 ES 2153284B1 ES 009801219 A ES009801219 A ES 009801219A ES 9801219 A ES9801219 A ES 9801219A ES 2153284 B1 ES2153284 B1 ES 2153284B1
Authority
ES
Spain
Prior art keywords
mixed
vaccines against
preparation
new recombinant
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009801219A
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English (en)
Other versions
ES2153284A1 (es
Inventor
De Riego Juan Barcena
Lozano Rafael Blasco
Camarzana Monica Morales
Mante Albert Pages
Fernandez Francisco Parra
Jose Manuel Sanchez-Vizcaino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUNDACION PARA EL ESTUDIO Y DE
Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA
Original Assignee
FUNDACION PARA EL ESTUDIO Y DE
Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FUNDACION PARA EL ESTUDIO Y DE, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA filed Critical FUNDACION PARA EL ESTUDIO Y DE
Priority to ES009801219A priority Critical patent/ES2153284B1/es
Priority to PT99500099T priority patent/PT972840E/pt
Priority to ES99500099T priority patent/ES2217718T3/es
Priority to EP99500099A priority patent/EP0972840B1/en
Publication of ES2153284A1 publication Critical patent/ES2153284A1/es
Application granted granted Critical
Publication of ES2153284B1 publication Critical patent/ES2153284B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/275—Poxviridae, e.g. avipoxvirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

"Nuevo virus recombinante de mixoma atenuado y su uso en la preparación de vacunas mixtas contra la mixomatosis y la enfermedad hemorrágica de los conejos". Se describe un nuevo virus recombinante de mixoma, depositado en el CNCM con el número de depósito I-1990, que contiene en su genoma una secuencia de nucleótidos capaz de expresar la proteína antigénica VP60 del virus de la enfermedad hemorrágica de los conejos, que es atenuado y tiene la capacidad de transmitirse de manera controlada, así como las vacunas mixtas anti-mixomatosis anti- RHDV autopropagables de manera controlada que se obtienen a partir de dicho virus. También se describe un método para la obtención de virus de mixoma recombinantes atenuados, útiles para preparar vacunas mixtas autopropagables contra la micomatosis y otras enfermedades infecciosas de los lepóridos.
ES009801219A 1998-06-10 1998-06-10 Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos. Expired - Fee Related ES2153284B1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES009801219A ES2153284B1 (es) 1998-06-10 1998-06-10 Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.
PT99500099T PT972840E (pt) 1998-06-10 1999-06-10 Novo virus myxoma recombinante atenuado e sua utilizacao para a preparacao de vacinas mistas contra a mixomatose e contra a doenca hemorragica dos coelhos
ES99500099T ES2217718T3 (es) 1998-06-10 1999-06-10 Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.
EP99500099A EP0972840B1 (en) 1998-06-10 1999-06-10 New attenuated myxoma recombinant virus and its use in the preparation of mixed vaccines against myxomatosis and rabbit hemorrhagic disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801219A ES2153284B1 (es) 1998-06-10 1998-06-10 Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.

Publications (2)

Publication Number Publication Date
ES2153284A1 ES2153284A1 (es) 2001-02-16
ES2153284B1 true ES2153284B1 (es) 2001-09-01

Family

ID=8304096

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801219A Expired - Fee Related ES2153284B1 (es) 1998-06-10 1998-06-10 Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.
ES99500099T Expired - Lifetime ES2217718T3 (es) 1998-06-10 1999-06-10 Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99500099T Expired - Lifetime ES2217718T3 (es) 1998-06-10 1999-06-10 Nuevo virus recombinante de mixoma atenuado y su uso en la preparacion de vacunas mixtas contra la mixomatosis y la enfermedad hemorragica de los conejos.

Country Status (3)

Country Link
EP (1) EP0972840B1 (es)
ES (2) ES2153284B1 (es)
PT (1) PT972840E (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072852A2 (en) * 2001-03-08 2002-09-19 Akzo Nobel N.V. Leporipox-based vector vaccines
CA2517147C (en) 2003-03-07 2011-06-14 Robarts Research Institute Use of myxoma virus for the therapeutic treatment of cancer and chronic viral infection
DE102004003572A1 (de) 2004-01-23 2005-08-18 Bavarian Nordic A/S Monoparamunitätsinducer basierend auf attenuierten Myxomaviren des Kaninchens
EP2021023A4 (en) 2006-06-01 2010-08-11 Robarts Res Inst MUTANTS OF MYXOMA VIRUS FOR THE TREATMENT OF CANCER
FR3080027B1 (fr) * 2018-04-13 2021-09-10 Anclatra Aveyron Procede de lutte contre le virus de la myxomatose
MX2022002547A (es) 2019-09-02 2022-05-18 Univ Arizona State Una nueva plataforma de virus oncoliticos para tratar canceres con virus myxoma.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2080024B1 (es) * 1994-07-06 1996-08-16 Univ Oviedo Vacuna subunitaria recombinante contra la enfermedad hemorragica virica de los conejos.
FR2736358B1 (fr) * 1995-07-05 1997-09-26 Agronomique Inst Nat Rech Virus myxomateux recombinant

Also Published As

Publication number Publication date
ES2217718T3 (es) 2004-11-01
EP0972840A3 (en) 2001-09-26
PT972840E (pt) 2004-07-30
EP0972840B1 (en) 2004-05-19
ES2153284A1 (es) 2001-02-16
EP0972840A2 (en) 2000-01-19

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