MX2022000988A - Proteinas de union a antigeno anti-il13. - Google Patents

Proteinas de union a antigeno anti-il13.

Info

Publication number
MX2022000988A
MX2022000988A MX2022000988A MX2022000988A MX2022000988A MX 2022000988 A MX2022000988 A MX 2022000988A MX 2022000988 A MX2022000988 A MX 2022000988A MX 2022000988 A MX2022000988 A MX 2022000988A MX 2022000988 A MX2022000988 A MX 2022000988A
Authority
MX
Mexico
Prior art keywords
antibodies
antigen binding
light chain
binding proteins
sequences
Prior art date
Application number
MX2022000988A
Other languages
English (en)
Inventor
Bram Estes
Agnieszka Kielczewska
Ian Nevin Foltz
Palaniswami Rathanaswami
Maria Sheena Amador
Igor D''angelo
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2022000988A publication Critical patent/MX2022000988A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invención se refiere a anticuerpos dirigidos contra la IL-13 y a los usos de dichos anticuerpos. Por ejemplo, de acuerdo con la presente invención, se proporcionan anticuerpos monoclonales humanos dirigidos contra la IL-13. Se proporcionan secuencias polinucleotídicas aisladas que codifican, y secuencias de aminoácidos que comprenden, moléculas de inmunoglobulina de cadena pesada y ligera, en particular secuencias correspondientes a secuencias de cadena pesada y ligera contiguas que abarcan las regiones marco conservadas (FR) y/o regiones determinantes de la complementariedad (CDR). Adicionalmente, también se proporcionan métodos de uso de estos anticuerpos para tratar pacientes.
MX2022000988A 2019-07-26 2020-07-24 Proteinas de union a antigeno anti-il13. MX2022000988A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962879335P 2019-07-26 2019-07-26
PCT/US2020/043607 WO2021021676A1 (en) 2019-07-26 2020-07-24 Anti-il13 antigen binding proteins

Publications (1)

Publication Number Publication Date
MX2022000988A true MX2022000988A (es) 2022-05-03

Family

ID=72139660

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022000988A MX2022000988A (es) 2019-07-26 2020-07-24 Proteinas de union a antigeno anti-il13.

Country Status (10)

Country Link
US (1) US20220281966A1 (es)
EP (1) EP4004041A1 (es)
JP (1) JP2022542890A (es)
AR (1) AR119496A1 (es)
AU (1) AU2020323901A1 (es)
CA (1) CA3148591A1 (es)
MX (1) MX2022000988A (es)
TW (1) TW202118783A (es)
UY (1) UY38807A (es)
WO (1) WO2021021676A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
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WO2023166418A2 (en) * 2022-03-03 2023-09-07 Pfizer Inc. Multispecific antibodies and uses thereof
WO2024097104A1 (en) * 2022-10-31 2024-05-10 Amgen Inc. Methods of antibody characterization

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Also Published As

Publication number Publication date
JP2022542890A (ja) 2022-10-07
AU2020323901A1 (en) 2022-02-24
UY38807A (es) 2021-02-26
TW202118783A (zh) 2021-05-16
EP4004041A1 (en) 2022-06-01
AR119496A1 (es) 2021-12-22
CA3148591A1 (en) 2021-02-04
WO2021021676A1 (en) 2021-02-04
US20220281966A1 (en) 2022-09-08

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