MX2022000603A - Anticuerpo anti-tau y uso del mismo. - Google Patents
Anticuerpo anti-tau y uso del mismo.Info
- Publication number
- MX2022000603A MX2022000603A MX2022000603A MX2022000603A MX2022000603A MX 2022000603 A MX2022000603 A MX 2022000603A MX 2022000603 A MX2022000603 A MX 2022000603A MX 2022000603 A MX2022000603 A MX 2022000603A MX 2022000603 A MX2022000603 A MX 2022000603A
- Authority
- MX
- Mexico
- Prior art keywords
- tau
- tau antibody
- present
- antibody according
- same
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Mycology (AREA)
Abstract
La presente invención se refiere a un anticuerpo anti-tau que se une específicamente a una proteína tau y sus usos. El anticuerpo anti-tau de acuerdo con la presente invención puede unirse específicamente a una proteína tau en la que la lisina 280 está acetilada, y puede suprimir la agregación anormal de proteínas tau. Además, el anticuerpo anti-tau de acuerdo con la presente invención, cuando se administra a un modelo animal de demencia inducido, puede mejorar la función locomotriz y capacidad cognitiva en el modelo animal. Por lo tanto, el anticuerpo anti-tau de acuerdo con la presente invención se puede usar en la prevención o tratamiento de enfermedades neurodegenerativas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20190085233 | 2019-07-15 | ||
PCT/KR2020/009207 WO2021010712A1 (ko) | 2019-07-15 | 2020-07-13 | 항-타우 항체 및 이의 용도 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022000603A true MX2022000603A (es) | 2022-05-20 |
Family
ID=74088428
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022000603A MX2022000603A (es) | 2019-07-15 | 2020-07-13 | Anticuerpo anti-tau y uso del mismo. |
Country Status (14)
Country | Link |
---|---|
US (1) | US20220204601A1 (es) |
EP (1) | EP4001305A4 (es) |
JP (1) | JP2022541539A (es) |
KR (1) | KR102196840B1 (es) |
CN (1) | CN114430744A (es) |
AU (1) | AU2020313751A1 (es) |
BR (1) | BR112022000719A2 (es) |
CA (1) | CA3143811A1 (es) |
CL (1) | CL2022000087A1 (es) |
GB (1) | GB2600599A (es) |
IL (1) | IL289813A (es) |
MX (1) | MX2022000603A (es) |
TW (1) | TW202116801A (es) |
WO (1) | WO2021010712A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2970453B1 (en) | 2013-03-13 | 2019-12-04 | Prothena Biosciences Limited | Tau immunotherapy |
WO2017191559A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Tau immunotherapy |
UA124148C2 (uk) | 2016-05-02 | 2021-07-28 | Протена Біосайенсіс Лімітед | Антитіла, що розпізнають тау |
BR112019022906A2 (pt) | 2017-05-02 | 2020-05-26 | Prothena Biosciences Limited | Anticorpos que reconhecem tau |
SG11202108414UA (en) | 2019-03-03 | 2021-08-30 | Prothena Biosciences Ltd | Antibodies recognizing tau |
WO2023039456A1 (en) * | 2021-09-09 | 2023-03-16 | The University Of North Carolina At Chapel Hill | Monoclonal antibodies targeting acetylated tau and methods of use thereof |
WO2023041805A1 (en) | 2021-09-20 | 2023-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor |
WO2023229445A1 (ko) * | 2022-05-27 | 2023-11-30 | 주식회사 진큐어 | 신규 펩타이드 및 그의 용도 |
CN116693682B (zh) * | 2023-06-02 | 2024-04-19 | 涌源合生科技(深圳)有限公司 | 抗Tau蛋白抗体及其制备方法和用途 |
CN116948025B (zh) * | 2023-09-14 | 2024-04-02 | 北京凯祥弘康生物科技有限公司 | 一种抗Tau蛋白的抗体 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20130251731A1 (en) * | 2012-03-22 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Tau Acetylation in the Pathogenesis of Alzheimers Disease and Other Related Tauopathies |
EP2834270B1 (en) * | 2012-04-05 | 2019-10-30 | AC Immune S.A. | Humanized tau antibody |
JP6345655B2 (ja) * | 2012-07-03 | 2018-06-20 | ワシントン・ユニバーシティWashington University | タウに対する抗体 |
TW202136296A (zh) * | 2014-06-27 | 2021-10-01 | 美商C2N醫療診斷有限責任公司 | 人類化抗-tau抗體 |
JO3576B1 (ar) * | 2015-02-26 | 2020-07-05 | Lilly Co Eli | أجسام مضادة لـ tau واستخداماتها |
WO2018106889A1 (en) * | 2016-12-09 | 2018-06-14 | Cogwellin L.L.C. | Diagnosis of alzheimer's disease |
KR102032314B1 (ko) * | 2016-12-21 | 2019-10-16 | 주식회사 아델 | 변이된 타우 단백질 단편 및 이의 용도 |
-
2020
- 2020-07-13 WO PCT/KR2020/009207 patent/WO2021010712A1/ko unknown
- 2020-07-13 JP JP2022503414A patent/JP2022541539A/ja active Pending
- 2020-07-13 CA CA3143811A patent/CA3143811A1/en active Pending
- 2020-07-13 MX MX2022000603A patent/MX2022000603A/es unknown
- 2020-07-13 AU AU2020313751A patent/AU2020313751A1/en active Pending
- 2020-07-13 BR BR112022000719A patent/BR112022000719A2/pt unknown
- 2020-07-13 EP EP20841174.4A patent/EP4001305A4/en active Pending
- 2020-07-13 CN CN202080063893.8A patent/CN114430744A/zh active Pending
- 2020-07-13 KR KR1020200086341A patent/KR102196840B1/ko active IP Right Grant
- 2020-07-13 GB GB2201160.5A patent/GB2600599A/en active Pending
- 2020-07-15 TW TW109123934A patent/TW202116801A/zh unknown
-
2022
- 2022-01-12 US US17/574,227 patent/US20220204601A1/en active Pending
- 2022-01-12 CL CL2022000087A patent/CL2022000087A1/es unknown
- 2022-01-12 IL IL289813A patent/IL289813A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2021010712A1 (ko) | 2021-01-21 |
EP4001305A1 (en) | 2022-05-25 |
EP4001305A4 (en) | 2022-10-12 |
GB2600599A (en) | 2022-05-04 |
BR112022000719A2 (pt) | 2022-03-29 |
TW202116801A (zh) | 2021-05-01 |
CL2022000087A1 (es) | 2023-03-10 |
JP2022541539A (ja) | 2022-09-26 |
IL289813A (en) | 2022-03-01 |
US20220204601A1 (en) | 2022-06-30 |
EP4001305A9 (en) | 2023-05-24 |
AU2020313751A1 (en) | 2022-02-10 |
CA3143811A1 (en) | 2021-01-21 |
CN114430744A (zh) | 2022-05-03 |
GB202201160D0 (en) | 2022-03-16 |
KR102196840B1 (ko) | 2020-12-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022000603A (es) | Anticuerpo anti-tau y uso del mismo. | |
AU2017291414B2 (en) | Anti-N3pGLu amyloid beta peptide antibodies and uses thereof | |
MY195474A (en) | Single Domain Antibody and Derivative Proteins Thereof Against Programmed Death Ligand (Pdl1) | |
MX2019007480A (es) | Anticuerpos monoclonales anti-alfa-sinucleina para prevenir la agregacion de tau. | |
WO2016079597A8 (en) | Humanized tau antibodies in alzheimer's disease | |
EP3563849A3 (en) | Combination therapies for the treatment of alzheimer's disease and related disorders | |
UA112743C2 (uk) | Терапевтичний dll4-зв'язувальний білок | |
MX2019003805A (es) | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. | |
TW201613964A (en) | Improved A[beta] protofibril binding antibodies | |
WO2018208011A3 (ko) | β-아밀로이드 단백질의 응집을 억제하는 생체친화적 펩타이드 | |
WO2019045248A3 (ko) | 주름 개선 활성을 나타내는 펩타이드 및 이의 용도 | |
AU2018264384A1 (en) | Solid forms of berberine ursodeoxycholate and compositions and methods thereof | |
MA45172B1 (fr) | Arn modifié codant pour des polypeptides vegf-a, formulations et utilisations associées | |
WO2022167816A3 (en) | Antibodies | |
EA202092557A1 (ru) | СОЕДИНЕНИЯ ТЕТРАГИДРОБЕНЗОФУРО[2,3-c]ПИРИДИНА И БЕТА-КАРБОЛИНА ДЛЯ ЛЕЧЕНИЯ, ОБЛЕГЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАССТРОЙСТВ, СВЯЗАННЫХ С АГРЕГАТАМИ ТАУ-БЕЛКА | |
EA201992688A1 (ru) | Средства, пути применения и способы лечения | |
AU2016210835A8 (en) | Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders | |
WO2021097223A3 (en) | Biparatopic cd73 antibodies | |
MX2022004143A (es) | Compuesto que tiene actividad inhibidora de brd4, su método de preparación y su uso. | |
WO2017197253A3 (en) | Peptides and methods for treating neurodegenerative disorders | |
IL290074A (en) | Peptides for use in the treatment of macular degeneration and other ocular disorders | |
WO2020186155A3 (en) | Synthetic neuromodulatory peptides | |
EP4061403A4 (en) | SECRETABLE PROTEIN-INDUCED IMMUNE TOLERANCE AND TREATMENT OF AUTOIMMUNE, ALLERGIC AND OTHER DISEASES AND DISORDERS | |
NZ700467A (en) | Treatments suitable for malassezia infections | |
JP2016539911A5 (es) |