MX2021015502A - Capsula de tipo desintegracion retardada y metodo para producir la misma. - Google Patents

Capsula de tipo desintegracion retardada y metodo para producir la misma.

Info

Publication number
MX2021015502A
MX2021015502A MX2021015502A MX2021015502A MX2021015502A MX 2021015502 A MX2021015502 A MX 2021015502A MX 2021015502 A MX2021015502 A MX 2021015502A MX 2021015502 A MX2021015502 A MX 2021015502A MX 2021015502 A MX2021015502 A MX 2021015502A
Authority
MX
Mexico
Prior art keywords
capsule
core
disintegration
producing same
delayed disintegration
Prior art date
Application number
MX2021015502A
Other languages
English (en)
Inventor
Kazuma Takahashi
Takehiro Nishikawa
Katsutoshi Ishii
Original Assignee
Morishita Jintan Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morishita Jintan Co filed Critical Morishita Jintan Co
Publication of MX2021015502A publication Critical patent/MX2021015502A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)

Abstract

Un objetivo de la presente invención es proporcionar una técnica para retardar la desintegración de una cápsula al mezclar un cierto componente en un núcleo de la cápsula, e incrementar el grado de libertad en el diseño de la cápsula; la presente invención se refiere a una cápsula sin costuras de tipo desintegración retardada que es una cápsula sin costuras que incluye un núcleo, una o más capas intermedias formadas en el núcleo y una capa más externa formada en las capas intermedias, en donde el núcleo contiene una sustancia activa, un agente tensoactivo anfotérico, y una grasa que tiene un punto de fusión de 40°C o más, por lo menos una capa de las capas intermedias contiene una grasa que tiene un punto de fusión de 45°C o más, y la capa más externa contiene un polímero natural soluble en agua; la presente invención también se refiere a un método para producir el mismo.
MX2021015502A 2019-06-14 2020-06-12 Capsula de tipo desintegracion retardada y metodo para producir la misma. MX2021015502A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019111280 2019-06-14
PCT/JP2020/023290 WO2020251039A1 (ja) 2019-06-14 2020-06-12 遅延崩壊型カプセルおよびその製造方法

Publications (1)

Publication Number Publication Date
MX2021015502A true MX2021015502A (es) 2022-02-10

Family

ID=73781468

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021015502A MX2021015502A (es) 2019-06-14 2020-06-12 Capsula de tipo desintegracion retardada y metodo para producir la misma.

Country Status (16)

Country Link
US (1) US20220226252A1 (es)
EP (1) EP3984530A4 (es)
JP (1) JPWO2020251039A1 (es)
KR (1) KR20220020800A (es)
CN (1) CN113924083A (es)
AU (1) AU2020291242A1 (es)
BR (1) BR112021024950A2 (es)
CA (1) CA3139731A1 (es)
CL (1) CL2021003286A1 (es)
CO (1) CO2021016625A2 (es)
CR (1) CR20220007A (es)
EC (1) ECSP22002699A (es)
MX (1) MX2021015502A (es)
SG (1) SG11202113107SA (es)
TW (1) TW202103689A (es)
WO (1) WO2020251039A1 (es)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS512401B1 (es) 1970-12-29 1976-01-26
JPS518875B2 (es) 1972-10-14 1976-03-22
JPS518176A (ja) 1974-07-11 1976-01-22 Morishita Jintan Co Tsugimenashitankakunijukapuserunoseizohohotokono hohoo jitsushisurutameno seizosochi
JPS60172343A (ja) 1984-02-15 1985-09-05 Akira Horikawa 多重マイクロカプセルの製造法およびその装置
JPH0753356A (ja) * 1993-08-16 1995-02-28 Morishita Jintan Kk 酸化され易い油性物質を内容物とするシームレスカプセルおよびその製造方法
JP3278273B2 (ja) * 1993-12-17 2002-04-30 キヤノン株式会社 薬剤徐放性カプセル
JP4309045B2 (ja) * 1997-10-30 2009-08-05 森下仁丹株式会社 不飽和脂肪酸またはその誘導体を内容物とするカプセル製剤およびその製造法
CN102470106B (zh) * 2009-05-18 2015-09-23 希格默伊德药业有限公司 包含油滴的组合物
EP2793867B1 (en) * 2011-12-22 2021-01-20 Baes, Erik Gelatin/alginate delayed release capsules comprising omega-3 fatty acids, and methods and uses thereof
CN104968356A (zh) 2012-12-21 2015-10-07 日清药业股份有限公司 大肠输送胶囊及其制备方法
JP2015199698A (ja) * 2014-03-31 2015-11-12 株式会社ファンケル シームレスカプセル
JP6468633B2 (ja) * 2014-10-03 2019-02-13 富士カプセル株式会社 三層構造シームレスカプセル
JP2017214335A (ja) * 2016-06-01 2017-12-07 アリメント工業株式会社 コエンザイムｑ１０組成物及びそれが充填されたソフトカプセル
IT201700021852A1 (it) * 2017-02-27 2018-08-27 Bioscreen Tech S R L Composizione a rilascio controllato di sostanze fisiologicamente attive e processo per la sua preparazione
WO2019111398A1 (ja) * 2017-12-08 2019-06-13 森下仁丹株式会社 非水素添加油脂で構成された三層構造カプセルおよびその製造方法

Also Published As

Publication number Publication date
ECSP22002699A (es) 2022-02-25
EP3984530A4 (en) 2023-01-25
KR20220020800A (ko) 2022-02-21
JPWO2020251039A1 (es) 2020-12-17
TW202103689A (zh) 2021-02-01
WO2020251039A1 (ja) 2020-12-17
CA3139731A1 (en) 2020-12-17
CN113924083A (zh) 2022-01-11
SG11202113107SA (en) 2021-12-30
AU2020291242A1 (en) 2022-02-24
CO2021016625A2 (es) 2022-01-17
EP3984530A1 (en) 2022-04-20
CL2021003286A1 (es) 2022-09-23
US20220226252A1 (en) 2022-07-21
BR112021024950A2 (pt) 2022-01-25
CR20220007A (es) 2022-01-31

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