MX2021013266A - Nuevas capsides de aav y composiciones que las contienen. - Google Patents
Nuevas capsides de aav y composiciones que las contienen.Info
- Publication number
- MX2021013266A MX2021013266A MX2021013266A MX2021013266A MX2021013266A MX 2021013266 A MX2021013266 A MX 2021013266A MX 2021013266 A MX2021013266 A MX 2021013266A MX 2021013266 A MX2021013266 A MX 2021013266A MX 2021013266 A MX2021013266 A MX 2021013266A
- Authority
- MX
- Mexico
- Prior art keywords
- novel aav
- compositions containing
- containing same
- aav capsids
- novel
- Prior art date
Links
- 210000000234 capsid Anatomy 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
En el presente documento se proporcionan nuevas cápsides de AAV y rAAV que las comprenden; en una forma de realización, los vectores que emplean una nueva cápside de AAV muestran una mayor transducción de un tejido diana seleccionado en comparación con un AAV de la técnica anterior.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962840184P | 2019-04-29 | 2019-04-29 | |
| US201962913314P | 2019-10-10 | 2019-10-10 | |
| US201962924095P | 2019-10-21 | 2019-10-21 | |
| PCT/US2020/030273 WO2020223232A1 (en) | 2019-04-29 | 2020-04-28 | Novel aav capsids and compositions containing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021013266A true MX2021013266A (es) | 2021-11-17 |
Family
ID=73028724
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021013266A MX2021013266A (es) | 2019-04-29 | 2020-04-28 | Nuevas capsides de aav y composiciones que las contienen. |
| MX2021013267A MX2021013267A (es) | 2019-04-29 | 2020-04-28 | Nuevas capsides de aav y composiciones que las contienen. |
| MX2021013268A MX2021013268A (es) | 2019-04-29 | 2020-04-28 | Nuevas capsides de aav y composiciones que las contienen. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021013267A MX2021013267A (es) | 2019-04-29 | 2020-04-28 | Nuevas capsides de aav y composiciones que las contienen. |
| MX2021013268A MX2021013268A (es) | 2019-04-29 | 2020-04-28 | Nuevas capsides de aav y composiciones que las contienen. |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20220204990A1 (es) |
| EP (3) | EP3976078A4 (es) |
| JP (3) | JP2022530656A (es) |
| KR (3) | KR20220004681A (es) |
| CN (3) | CN113853208A (es) |
| AU (3) | AU2020264976A1 (es) |
| BR (3) | BR112021021502A2 (es) |
| CA (3) | CA3134379A1 (es) |
| CL (3) | CL2021002768A1 (es) |
| CO (3) | CO2021015924A2 (es) |
| IL (3) | IL287492A (es) |
| MX (3) | MX2021013266A (es) |
| PE (3) | PE20212267A1 (es) |
| SG (3) | SG11202111373YA (es) |
| WO (3) | WO2020223232A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022016528A (es) | 2020-06-17 | 2023-06-02 | Univ Pennsylvania | Composiciones y métodos para el tratamiento de pacientes de terapia génica. |
| JP2023543125A (ja) | 2020-08-24 | 2023-10-13 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Ｇｌｐ－１受容体アゴニスト融合物をコードするウイルスベクター及び代謝性疾患の治療におけるその使用 |
| WO2022094078A1 (en) | 2020-10-28 | 2022-05-05 | The Trustees Of The University Of Pennsylvania | Compositions useful in treatment of rett syndrome |
| JP2023548432A (ja) | 2020-11-11 | 2023-11-16 | ヨーロピアン モレキュラー バイオロジー ラボラトリー | 遺伝子療法のための改変ウイルス粒子 |
| TW202237850A (zh) | 2020-12-01 | 2022-10-01 | 賓州大學委員會 | 具有組織特異性靶向基序的新穎構成物及含有其之組成物 |
| IL303239A (en) * | 2020-12-01 | 2023-07-01 | Univ Pennsylvania | Compositions and their uses for the treatment of Engelmann syndrome |
| AU2022262771A1 (en) | 2021-04-23 | 2023-11-02 | The Trustees Of The University Of Pennsylvania | Novel compositions with brain-specific targeting motifs and compositions containing same |
| WO2023147304A1 (en) | 2022-01-25 | 2023-08-03 | The Trustees Of The University Of Pennsylvania | Aav capsids for improved heart transduction and detargeting of liver |
| WO2023168293A2 (en) * | 2022-03-01 | 2023-09-07 | The Trustees Of The University Of Pennsylvania | Viral vector genome encoding an insulin fusion protein |
| WO2023168403A2 (en) * | 2022-03-03 | 2023-09-07 | The Trustees Of The University Of Pennsylvania | Viral vectors encoding parathyroid hormone fusions and uses thereof in treating hypoparathyroidism |
| WO2023196893A1 (en) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating her2 positive metastatic breast cancer and other cancers |
| WO2023196892A1 (en) | 2022-04-06 | 2023-10-12 | The Trustees Of The University Of Pennsylvania | Passive immunization with anti- aav neutralizing antibodies to prevent off-target transduction of intrathecally delivered aav vectors |
| WO2024015966A2 (en) * | 2022-07-15 | 2024-01-18 | The Trustees Of The University Of Pennsylvania | Recombinant aav having aav clade d and clade e capsids and compositions containing same |
| WO2024130070A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof |
| WO2024130067A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav mutant vectors with cardiac and skeletal muscle-specific targeting motifs and compositions containing same |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2338900B1 (en) * | 2001-11-13 | 2014-01-01 | The Trustees of The University of Pennsylvania | Adeno-associated virus (AAV) Cy.5 sequences, vectors containing the same and uses thereof |
| DK2292779T3 (en) * | 2003-09-30 | 2017-02-27 | Univ Pennsylvania | ADENOASS-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME AND APPLICATIONS THEREOF |
| CN106906241B (zh) * | 2005-04-07 | 2020-09-11 | 宾夕法尼亚大学托管会 | 增强腺相关病毒载体功能的方法 |
| EP2016174A2 (en) * | 2006-04-28 | 2009-01-21 | The Trustees of the University of Pennsylvania | Modified aav vectors having reduced capsid immunogenicity and use thereof |
| JP5963743B2 (ja) * | 2010-04-23 | 2016-08-03 | ユニバーシティ オブ マサチューセッツ | Ｃｎｓターゲティングａａｖベクターおよびその使用方法 |
| MX2016011585A (es) * | 2014-03-10 | 2016-11-29 | Uniqure Ip Bv | Vectores aav mejorados adicionales producidos en celulas de insecto. |
| US10577627B2 (en) * | 2014-06-09 | 2020-03-03 | Voyager Therapeutics, Inc. | Chimeric capsids |
| US20180021364A1 (en) * | 2015-01-16 | 2018-01-25 | Voyager Therapeutics, Inc. | Central nervous system targeting polynucleotides |
| DK3872085T3 (da) * | 2015-07-30 | 2023-04-03 | Massachusetts Eye & Ear Infirmary | Stam-virussekvenser og anvendelser heraf |
| US20180230489A1 (en) * | 2015-10-28 | 2018-08-16 | Voyager Therapeutics, Inc. | Regulatable expression using adeno-associated virus (aav) |
| CA3002406A1 (en) * | 2015-10-29 | 2017-05-04 | Voyager Therapeutics, Inc. | Delivery of central nervous system targeting polynucleotides |
| US11326182B2 (en) * | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| AU2017267665C1 (en) * | 2016-05-18 | 2023-10-05 | Voyager Therapeutics, Inc. | Modulatory polynucleotides |
| US11192925B2 (en) * | 2016-10-19 | 2021-12-07 | Adverum Biotechnologies, Inc. | Modified AAV capsids and uses thereof |
| US10550405B2 (en) * | 2017-03-15 | 2020-02-04 | The University Of North Carolina At Chapel Hill | Rational polyploid adeno-associated virus vectors and methods of making and using the same |
| WO2018200419A1 (en) * | 2017-04-23 | 2018-11-01 | The Trustees Of The University Of Pennsylvania | Viral vectors comprising engineered aav capsids and compositions containing the same |
| JOP20190269A1 (ar) * | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| US11512327B2 (en) * | 2017-08-03 | 2022-11-29 | Voyager Therapeutics, Inc. | Compositions and methods for delivery of AAV |
-
2020
- 2020-04-28 MX MX2021013266A patent/MX2021013266A/es unknown
- 2020-04-28 CA CA3134379A patent/CA3134379A1/en active Pending
- 2020-04-28 PE PE2021001795A patent/PE20212267A1/es unknown
- 2020-04-28 EP EP20798752.0A patent/EP3976078A4/en active Pending
- 2020-04-28 CA CA3134507A patent/CA3134507A1/en active Pending
- 2020-04-28 JP JP2021564543A patent/JP2022530656A/ja active Pending
- 2020-04-28 AU AU2020264976A patent/AU2020264976A1/en active Pending
- 2020-04-28 JP JP2021564269A patent/JP2022530633A/ja active Pending
- 2020-04-28 MX MX2021013267A patent/MX2021013267A/es unknown
- 2020-04-28 BR BR112021021502A patent/BR112021021502A2/pt unknown
- 2020-04-28 PE PE2021001789A patent/PE20212334A1/es unknown
- 2020-04-28 JP JP2021564542A patent/JP2022530544A/ja active Pending
- 2020-04-28 CN CN202080032773.1A patent/CN113853208A/zh active Pending
- 2020-04-28 PE PE2021001788A patent/PE20220014A1/es unknown
- 2020-04-28 BR BR112021020545A patent/BR112021020545A2/pt unknown
- 2020-04-28 BR BR112021020054A patent/BR112021020054A2/pt unknown
- 2020-04-28 SG SG11202111373YA patent/SG11202111373YA/en unknown
- 2020-04-28 AU AU2020266523A patent/AU2020266523A1/en active Pending
- 2020-04-28 CN CN202080032666.9A patent/CN113853207A/zh active Pending
- 2020-04-28 KR KR1020217037661A patent/KR20220004681A/ko unknown
- 2020-04-28 EP EP20798442.8A patent/EP3976077A4/en active Pending
- 2020-04-28 CN CN202080033196.8A patent/CN113853209A/zh active Pending
- 2020-04-28 US US17/605,868 patent/US20220204990A1/en active Pending
- 2020-04-28 US US17/605,874 patent/US20220220453A1/en active Pending
- 2020-04-28 EP EP20798753.8A patent/EP3962507A4/en active Pending
- 2020-04-28 US US17/605,881 patent/US20220249705A1/en active Pending
- 2020-04-28 MX MX2021013268A patent/MX2021013268A/es unknown
- 2020-04-28 WO PCT/US2020/030273 patent/WO2020223232A1/en active Application Filing
- 2020-04-28 SG SG11202111375RA patent/SG11202111375RA/en unknown
- 2020-04-28 CA CA3134468A patent/CA3134468A1/en active Pending
- 2020-04-28 AU AU2020264975A patent/AU2020264975A1/en active Pending
- 2020-04-28 WO PCT/US2020/030281 patent/WO2020223236A1/en active Application Filing
- 2020-04-28 KR KR1020217038207A patent/KR20220004695A/ko unknown
- 2020-04-28 WO PCT/US2020/030266 patent/WO2020223231A1/en active Application Filing
- 2020-04-28 KR KR1020217037659A patent/KR20220004680A/ko unknown
- 2020-04-28 SG SG11202111102SA patent/SG11202111102SA/en unknown
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2021
- 2021-10-21 IL IL287492A patent/IL287492A/en unknown
- 2021-10-21 CL CL2021002768A patent/CL2021002768A1/es unknown
- 2021-10-21 IL IL287491A patent/IL287491A/en unknown
- 2021-10-21 IL IL287498A patent/IL287498A/en unknown
- 2021-10-26 CL CL2021002811A patent/CL2021002811A1/es unknown
- 2021-10-27 CL CL2021002824A patent/CL2021002824A1/es unknown
- 2021-11-25 CO CONC2021/0015924A patent/CO2021015924A2/es unknown
- 2021-11-25 CO CONC2021/0015928A patent/CO2021015928A2/es unknown
- 2021-11-25 CO CONC2021/0015916A patent/CO2021015916A2/es unknown
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