MX2021012078A - Produccion continua de proteinas recombinantes. - Google Patents

Produccion continua de proteinas recombinantes.

Info

Publication number
MX2021012078A
MX2021012078A MX2021012078A MX2021012078A MX2021012078A MX 2021012078 A MX2021012078 A MX 2021012078A MX 2021012078 A MX2021012078 A MX 2021012078A MX 2021012078 A MX2021012078 A MX 2021012078A MX 2021012078 A MX2021012078 A MX 2021012078A
Authority
MX
Mexico
Prior art keywords
continuous production
recombinant proteins
systems
methods
disclosure relates
Prior art date
Application number
MX2021012078A
Other languages
English (en)
Inventor
Kevin Brower
Tarl Vetter
Michael Coolbaugh
Chad Varner
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2021012078A publication Critical patent/MX2021012078A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2688—Biological processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2697—Chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/08—Fully permeating type; Dead-end filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente divulgación se refiere a métodos y sistemas para la producción continua de proteínas recombinantes. En modalidades particulares, la divulgación se refiere a métodos y sistemas que utilizan cromatografía de captura, cromatografía post-captura, filtración de virus, y ultrafiltración/diafiltración para la producción continua de proteínas recombinantes.
MX2021012078A 2019-04-03 2020-04-01 Produccion continua de proteinas recombinantes. MX2021012078A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962828755P 2019-04-03 2019-04-03
PCT/US2020/026107 WO2020205928A1 (en) 2019-04-03 2020-04-01 Continuous production of recombinant proteins

Publications (1)

Publication Number Publication Date
MX2021012078A true MX2021012078A (es) 2022-01-04

Family

ID=70482780

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021012078A MX2021012078A (es) 2019-04-03 2020-04-01 Produccion continua de proteinas recombinantes.

Country Status (13)

Country Link
US (2) US11912741B2 (es)
EP (1) EP3947705A1 (es)
JP (1) JP2022519950A (es)
KR (1) KR20210149117A (es)
CN (1) CN113825840A (es)
AU (1) AU2020253381A1 (es)
BR (1) BR112021019217A2 (es)
CA (1) CA3135611A1 (es)
IL (1) IL286745A (es)
MX (1) MX2021012078A (es)
SG (1) SG11202110909XA (es)
TW (1) TW202102519A (es)
WO (1) WO2020205928A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021197249A1 (zh) * 2020-03-30 2021-10-07 上海复宏汉霖生物技术股份有限公司 一种用于靶分子连续纯化的系统和方法
KR20240013153A (ko) * 2021-05-25 2024-01-30 베링거 인겔하임 인터내셔날 게엠베하 통합된 연속 바이러스 여과, 농축 및 버퍼 교환을 위한 방법 및 시스템
WO2022248623A1 (en) * 2021-05-26 2022-12-01 Simabs Nv Integrated continuous bioprocess production platform
CA3233651A1 (en) * 2021-09-28 2023-04-06 Merck Patent Gmbh Integrated solution for process intensification using inline constantly pressurized tank: "icpt"
WO2023167584A1 (en) * 2022-03-01 2023-09-07 Biosanapharma B.V. Continuous manufacturing of a biological substance with process traceability
EP4252882A1 (en) * 2022-03-31 2023-10-04 Sartorius Stedim Biotech GmbH Separation system for separating and purifying a target component
US20240101945A1 (en) * 2022-09-28 2024-03-28 Genzyme Corporation Systems and devices for producing biological products and methods of using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100933766B1 (ko) 2001-11-20 2009-12-24 버콘 뉴트라사이언스 (엠비) 코포레이션 기름 종자 단백질 분리물의 연속 제조 방법
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
EP3578522A1 (en) * 2010-12-06 2019-12-11 Pall Corporation Continuous processing methods for biological products
RU2768003C2 (ru) * 2013-03-08 2022-03-22 Джензим Корпорейшн Интегрированное непрерывное производство терапевтических белковых лекарственных веществ
DK3301115T3 (da) * 2013-05-06 2022-01-31 Sanofi Sa Kontinuerlig flertrinsfremgangsmåde til oprensning af antistoffer
US8946395B1 (en) * 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US20170058308A1 (en) * 2014-05-02 2017-03-02 Novo Nordisk A/S Integrated continuous biomanufacturing process
EP4218991A1 (en) * 2014-05-13 2023-08-02 Amgen Inc. Process control systems and methods for use with filters and filtration processes
KR102379845B1 (ko) * 2014-05-30 2022-03-28 피네쎄 솔루션스, 아이엔씨 바이오 프로세스 컨테이너용 무균 접속기
US20170183376A1 (en) * 2014-06-24 2017-06-29 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
BR112019003013A2 (pt) 2016-08-16 2019-05-14 Genzyme Corporation métodos de processamento de um fluido incluindo uma proteína terapêutica recombinante e uso do mesmo
EP3592372A4 (en) * 2017-03-09 2021-01-13 Alexion Pharmaceuticals, Inc. GLYCOPROTEIN MANUFACTURING PROCESS

Also Published As

Publication number Publication date
US20240150395A1 (en) 2024-05-09
CN113825840A (zh) 2021-12-21
KR20210149117A (ko) 2021-12-08
TW202102519A (zh) 2021-01-16
US11912741B2 (en) 2024-02-27
CA3135611A1 (en) 2020-10-08
US20200317728A1 (en) 2020-10-08
WO2020205928A1 (en) 2020-10-08
EP3947705A1 (en) 2022-02-09
JP2022519950A (ja) 2022-03-25
AU2020253381A1 (en) 2021-12-02
IL286745A (en) 2021-10-31
BR112021019217A2 (pt) 2021-11-30
SG11202110909XA (en) 2021-10-28

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