MX2021011733A - Metodos para la extraccion y purificacion continua de un extracto unico de flavan-3-ol de racimos de uvas enteras inmaduras y composiciones del mismo. - Google Patents
Metodos para la extraccion y purificacion continua de un extracto unico de flavan-3-ol de racimos de uvas enteras inmaduras y composiciones del mismo.Info
- Publication number
- MX2021011733A MX2021011733A MX2021011733A MX2021011733A MX2021011733A MX 2021011733 A MX2021011733 A MX 2021011733A MX 2021011733 A MX2021011733 A MX 2021011733A MX 2021011733 A MX2021011733 A MX 2021011733A MX 2021011733 A MX2021011733 A MX 2021011733A
- Authority
- MX
- Mexico
- Prior art keywords
- flavan
- final product
- continuous extraction
- purification
- extract
- Prior art date
Links
- 229930182497 flavan-3-ol Natural products 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- OEIJRRGCTVHYTH-UHFFFAOYSA-N Favan-3-ol Chemical compound OC1CC2=CC=CC=C2OC1C1=CC=CC=C1 OEIJRRGCTVHYTH-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000605 extraction Methods 0.000 title abstract 3
- 235000009754 Vitis X bourquina Nutrition 0.000 title abstract 2
- 235000012333 Vitis X labruscana Nutrition 0.000 title abstract 2
- 240000006365 Vitis vinifera Species 0.000 title abstract 2
- 235000014787 Vitis vinifera Nutrition 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 239000012467 final product Substances 0.000 abstract 5
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000007171 acid catalysis Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229920002770 condensed tannin Polymers 0.000 abstract 1
- 150000002206 flavan-3-ols Chemical class 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 1
- 235000013824 polyphenols Nutrition 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/30—Other Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pyrane Compounds (AREA)
- Medicinal Preparation (AREA)
- Non-Alcoholic Beverages (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Preparation Of Fruits And Vegetables (AREA)
Abstract
La presente descripción proporciona un proceso novedoso para la extracción, purificación y producción continua de un extracto de flavan-3-ol de racimos de uvas enteras cosechadas tempranamente. El producto final de este proceso es particularmente rico en flavan-3-oles monoméricos y oligoméricos y con una conversión inusualmente alta del producto final en subunidades de flavan-3-ol bajo condiciones de catálisis ácida. Los oligómeros y polímeros en el producto final se refieren frecuentemente como proantocianidinas en el campo de la química de polifenoles. La descripción proporciona un proceso novedoso para la producción del producto final mediante un proceso de extracción continua y con un producto final que tiene una composición única.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962823390P | 2019-03-25 | 2019-03-25 | |
PCT/US2020/022958 WO2020197828A1 (en) | 2019-03-25 | 2020-03-16 | Methods for continuous extraction and purification of a unique flavan-3-ol extract from immature whole grape clusters and compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021011733A true MX2021011733A (es) | 2021-10-22 |
Family
ID=72609052
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021011733A MX2021011733A (es) | 2019-03-25 | 2020-03-16 | Metodos para la extraccion y purificacion continua de un extracto unico de flavan-3-ol de racimos de uvas enteras inmaduras y composiciones del mismo. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220160810A1 (es) |
EP (1) | EP3946286A4 (es) |
JP (1) | JP2022526959A (es) |
KR (1) | KR20210142697A (es) |
CN (1) | CN113874003A (es) |
AU (1) | AU2020244715A1 (es) |
BR (1) | BR112021019150A2 (es) |
CA (1) | CA3134699A1 (es) |
CL (1) | CL2021002468A1 (es) |
IL (1) | IL286597A (es) |
MX (1) | MX2021011733A (es) |
WO (1) | WO2020197828A1 (es) |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6544581B1 (en) * | 1999-06-22 | 2003-04-08 | Canandaigua Wine Company, Inc. | Process for extraction, purification and enrichment of polyphenolic substances from whole grapes, grape seeds and grape pomace |
BR0107486A (pt) * | 2000-01-11 | 2002-10-08 | Biorex Health Ltd | Método de extração de uma aglicona flavonóide a partir de material inicial contendo uma glicosida flavonóide e/ou conjugado dela proveniente |
US20020001651A1 (en) * | 2000-01-24 | 2002-01-03 | Norris Leslie Marie | Method of altering and improving taste characteristics of edible consumables with monomeric or oligomeric polyphenolic compounds |
ITMI20051485A1 (it) * | 2005-07-29 | 2007-01-30 | Indena Spa | Estratto da semi d'uva ottenibile per frazionamento su resina |
JP5424641B2 (ja) * | 2005-09-28 | 2014-02-26 | コンステレーション・ブランズ・インコーポレーテッド | ブドウ抽出物、そのダイエタリーサプリメント、およびその方法 |
AU2012244182B2 (en) * | 2005-09-28 | 2013-09-19 | E. & J. Gallo Winery | Grape extract, dietary supplement thereof, and processes therefor |
ES2337868B1 (es) * | 2008-10-16 | 2011-03-10 | Universitat Rovira I Virgili | Composicion para el tratamiento del sindrome metabolico. |
US20120135109A1 (en) * | 2010-11-30 | 2012-05-31 | Tropicana Products, Inc. | Fiber obtained from fruit or vegetable byproducts |
US20150259315A1 (en) * | 2014-03-14 | 2015-09-17 | Constellation Brands, Inc. | Grape extract, dietary supplement thereof, and processes therefor |
CN106455637A (zh) * | 2014-05-30 | 2017-02-22 | 嘉康利公司 | 霞多丽葡萄籽提取物 |
-
2020
- 2020-03-16 BR BR112021019150A patent/BR112021019150A2/pt unknown
- 2020-03-16 EP EP20778617.9A patent/EP3946286A4/en not_active Withdrawn
- 2020-03-16 CA CA3134699A patent/CA3134699A1/en active Pending
- 2020-03-16 AU AU2020244715A patent/AU2020244715A1/en not_active Abandoned
- 2020-03-16 MX MX2021011733A patent/MX2021011733A/es unknown
- 2020-03-16 US US17/442,483 patent/US20220160810A1/en active Pending
- 2020-03-16 KR KR1020217033886A patent/KR20210142697A/ko not_active Application Discontinuation
- 2020-03-16 CN CN202080035847.7A patent/CN113874003A/zh active Pending
- 2020-03-16 WO PCT/US2020/022958 patent/WO2020197828A1/en unknown
- 2020-03-16 JP JP2021557595A patent/JP2022526959A/ja active Pending
-
2021
- 2021-09-22 IL IL286597A patent/IL286597A/en unknown
- 2021-09-23 CL CL2021002468A patent/CL2021002468A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2022526959A (ja) | 2022-05-27 |
KR20210142697A (ko) | 2021-11-25 |
BR112021019150A2 (pt) | 2021-12-07 |
EP3946286A4 (en) | 2022-12-21 |
US20220160810A1 (en) | 2022-05-26 |
CL2021002468A1 (es) | 2022-06-10 |
CN113874003A (zh) | 2021-12-31 |
EP3946286A1 (en) | 2022-02-09 |
CA3134699A1 (en) | 2020-10-01 |
WO2020197828A1 (en) | 2020-10-01 |
IL286597A (en) | 2021-12-01 |
AU2020244715A1 (en) | 2021-10-14 |
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