MX2021008823A - Cuantificacion e identificacion de dimeros en coformulaciones. - Google Patents

Cuantificacion e identificacion de dimeros en coformulaciones.

Info

Publication number
MX2021008823A
MX2021008823A MX2021008823A MX2021008823A MX2021008823A MX 2021008823 A MX2021008823 A MX 2021008823A MX 2021008823 A MX2021008823 A MX 2021008823A MX 2021008823 A MX2021008823 A MX 2021008823A MX 2021008823 A MX2021008823 A MX 2021008823A
Authority
MX
Mexico
Prior art keywords
quantitation
identification
dimers
formulations
methods
Prior art date
Application number
MX2021008823A
Other languages
English (en)
Inventor
Shunhai Wang
Yuetian Yan
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2021008823A publication Critical patent/MX2021008823A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se proporcionan métodos y sistema para la identificación de especies diméricas mediante el uso de cromatografía en línea y espectrometría de masas de ionización por electropulverización. También se proporcionan métodos y sistema para la cuantificación de especies heterodiméricas mediante el uso de inmunoprecipitación y cromatografía líquida-espectrometría de masas.
MX2021008823A 2019-01-25 2020-01-23 Cuantificacion e identificacion de dimeros en coformulaciones. MX2021008823A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962796794P 2019-01-25 2019-01-25
US201962852591P 2019-05-24 2019-05-24
PCT/US2020/014825 WO2020154525A1 (en) 2019-01-25 2020-01-23 Quantitation and identification of dimers in co-formulations

Publications (1)

Publication Number Publication Date
MX2021008823A true MX2021008823A (es) 2021-09-08

Family

ID=69740545

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021008823A MX2021008823A (es) 2019-01-25 2020-01-23 Cuantificacion e identificacion de dimeros en coformulaciones.

Country Status (12)

Country Link
US (3) US11536725B2 (es)
EP (1) EP3914908A1 (es)
JP (1) JP2022518254A (es)
KR (1) KR20210120042A (es)
CN (1) CN113348364A (es)
AU (1) AU2020212022A1 (es)
BR (1) BR112021014427A2 (es)
CA (1) CA3126719A1 (es)
IL (1) IL284829A (es)
MX (1) MX2021008823A (es)
SG (1) SG11202107588YA (es)
WO (1) WO2020154525A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3084837A1 (en) 2018-01-29 2019-08-01 Ion Opticks Research Pty Ltd Capillary fitting
CA3126719A1 (en) * 2019-01-25 2020-07-30 Regeneron Pharmaceuticals, Inc. Quantitation and identification of dimers in co-formulations
CN113301974A (zh) 2019-01-25 2021-08-24 瑞泽恩制药公司 在线色谱法和电喷雾电离质谱仪
MX2022016104A (es) * 2020-06-18 2023-02-01 Regeneron Pharma Enfoque de peptidos pesados para medir con precision lisina de extremo c-terminal sin procesar.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
CN1302337C (zh) 2002-03-08 2007-02-28 Asml荷兰有限公司 光刻投射设备、所用的反射掩模以及器件制作方法
US7329353B2 (en) * 2004-01-23 2008-02-12 Amgen Inc. LC/MS method of analyzing high molecular weight proteins
JP4643290B2 (ja) * 2005-01-31 2011-03-02 ジーエルサイエンス株式会社 微小流量の流体制御方法及び装置
CN102162808B (zh) * 2010-12-28 2013-01-30 郭凯 一种基于体积排阻色谱/质谱法的动态组合化学方法
CA2848520C (en) * 2011-09-29 2019-11-26 Seattle Genetics, Inc. Intact mass determination of protein conjugated agent compounds
US11092574B2 (en) * 2013-12-24 2021-08-17 Waters Technologies Corporation Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides
EP3248210A1 (en) * 2015-01-23 2017-11-29 California Institute of Technology Integrated hybrid nems mass spectrometry
EP3425386B1 (en) * 2017-07-07 2022-04-13 Université de Strasbourg Online apparatus for in-depth characterization of antibody drug conjugates
BR112021008210A2 (pt) * 2018-10-31 2021-08-03 Regeneron Pharmaceuticals, Inc. método e sistema de identificação e quantificação de uma proteína
MX2021008791A (es) * 2019-01-25 2021-08-24 Regeneron Pharma Cromatografia de proteina a - espectrometro de masas de ionizacion por electrospray.
CA3126719A1 (en) * 2019-01-25 2020-07-30 Regeneron Pharmaceuticals, Inc. Quantitation and identification of dimers in co-formulations
CN113301974A (zh) * 2019-01-25 2021-08-24 瑞泽恩制药公司 在线色谱法和电喷雾电离质谱仪

Also Published As

Publication number Publication date
CN113348364A (zh) 2021-09-03
US20230070556A1 (en) 2023-03-09
BR112021014427A2 (pt) 2021-09-28
JP2022518254A (ja) 2022-03-14
KR20210120042A (ko) 2021-10-06
US20240210414A1 (en) 2024-06-27
US20200240998A1 (en) 2020-07-30
US11536725B2 (en) 2022-12-27
WO2020154525A1 (en) 2020-07-30
CA3126719A1 (en) 2020-07-30
SG11202107588YA (en) 2021-08-30
IL284829A (en) 2021-08-31
EP3914908A1 (en) 2021-12-01
AU2020212022A1 (en) 2021-07-29
US11899023B2 (en) 2024-02-13

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