MX2021007322A - Formulaciones farmaceuticas que contienen relacorilant, un compuesto de azadecalina fusionado con heteroaril-cetona. - Google Patents
Formulaciones farmaceuticas que contienen relacorilant, un compuesto de azadecalina fusionado con heteroaril-cetona.Info
- Publication number
- MX2021007322A MX2021007322A MX2021007322A MX2021007322A MX2021007322A MX 2021007322 A MX2021007322 A MX 2021007322A MX 2021007322 A MX2021007322 A MX 2021007322A MX 2021007322 A MX2021007322 A MX 2021007322A MX 2021007322 A MX2021007322 A MX 2021007322A
- Authority
- MX
- Mexico
- Prior art keywords
- relacorilant
- formulations containing
- heteroaryl
- pharmaceutical formulations
- disorders
- Prior art date
Links
- WANIDIGFXJFFEL-SANMLTNESA-N [(4ar)-1-(4-fluorophenyl)-6-(1-methylpyrazol-4-yl)sulfonyl-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)pyridin-2-yl]methanone Chemical compound C1=NN(C)C=C1S(=O)(=O)N1C[C@@]2(C(=O)C=3N=CC=C(C=3)C(F)(F)F)CC(C=NN3C=4C=CC(F)=CC=4)=C3C=C2CC1 WANIDIGFXJFFEL-SANMLTNESA-N 0.000 title abstract 5
- 229940070103 relacorilant Drugs 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 4
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 abstract 2
- 239000002775 capsule Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000002552 dosage form Substances 0.000 abstract 2
- 208000014311 Cushing syndrome Diseases 0.000 abstract 1
- 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 abstract 1
- 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
En la presente se divulgan nuevas formulaciones que contienen relacorilant ((R)-(1-(4-fluorofenil)-6-((1-metil-1H-pirazol-4-il)s ulfonil)-4,4a,5,6,7,8-hexahidro-1H-pirazolo[3,4-g]isoquinolin-4a- il)(4-(trifluorometil)piridin-2-il)metanona) que son adecuadas para ser administradas, incluyendo administración oral, a pacientes que padecen de trastornos que se prestan al tratamiento con moduladores de receptores de glucocorticoides (GRM). Las formas farmacéuticas de una sola unidad comprenden cápsulas blandas que contienen estas formulaciones. Dichas cápsulas blandas pueden contener, p.ej., formulaciones de relacorilant que contienen 25 miligramos (mg), 50 mg, 100 mg, 200 mg, 300 mg, 400 mg, 500 mg u otras cantidades de relacorilant. Estas nuevas formulaciones y formas farmacéuticas de una sola unidad se pueden usar para tratar enfermedades y trastornos incluyendo síndrome de Cushing, enfermedad de Cushing y otros trastornos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862781983P | 2018-12-19 | 2018-12-19 | |
PCT/US2019/067108 WO2020132023A1 (en) | 2018-12-19 | 2019-12-18 | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021007322A true MX2021007322A (es) | 2021-07-07 |
Family
ID=71098974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021007322A MX2021007322A (es) | 2018-12-19 | 2019-12-18 | Formulaciones farmaceuticas que contienen relacorilant, un compuesto de azadecalina fusionado con heteroaril-cetona. |
Country Status (16)
Country | Link |
---|---|
US (2) | US11464764B2 (es) |
EP (1) | EP3897589A4 (es) |
JP (1) | JP7218438B2 (es) |
KR (1) | KR102657097B1 (es) |
CN (2) | CN113194931B (es) |
AU (1) | AU2019404026B2 (es) |
BR (1) | BR112021010461A2 (es) |
CA (1) | CA3121193C (es) |
CL (1) | CL2021001528A1 (es) |
IL (1) | IL284061A (es) |
MX (1) | MX2021007322A (es) |
NZ (1) | NZ776354A (es) |
PH (1) | PH12021551449A1 (es) |
SG (1) | SG11202105770YA (es) |
WO (1) | WO2020132023A1 (es) |
ZA (1) | ZA202103561B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
SG11202105770YA (en) | 2018-12-19 | 2021-07-29 | Corcept Therapeutics Inc | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
WO2021242916A1 (en) * | 2020-05-27 | 2021-12-02 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and cyp2c9 substrates |
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EP3927345A4 (en) | 2019-02-22 | 2022-12-21 | Corcept Therapeutics Incorporated | THERAPEUTIC USES OF RELACORILANT, A GLUCOCORTICOID RECEPTOR MODULATOR DERIVED FROM AZADECALIN FUSED TO A HETEROARYL KETONE |
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2019
- 2019-12-18 SG SG11202105770YA patent/SG11202105770YA/en unknown
- 2019-12-18 US US16/719,644 patent/US11464764B2/en active Active
- 2019-12-18 NZ NZ776354A patent/NZ776354A/en unknown
- 2019-12-18 WO PCT/US2019/067108 patent/WO2020132023A1/en unknown
- 2019-12-18 CN CN201980084873.6A patent/CN113194931B/zh active Active
- 2019-12-18 AU AU2019404026A patent/AU2019404026B2/en active Active
- 2019-12-18 BR BR112021010461-5A patent/BR112021010461A2/pt unknown
- 2019-12-18 EP EP19898009.6A patent/EP3897589A4/en active Pending
- 2019-12-18 CN CN202311309741.3A patent/CN117281790A/zh active Pending
- 2019-12-18 KR KR1020217022598A patent/KR102657097B1/ko active IP Right Grant
- 2019-12-18 CA CA3121193A patent/CA3121193C/en active Active
- 2019-12-18 MX MX2021007322A patent/MX2021007322A/es unknown
- 2019-12-18 JP JP2021536303A patent/JP7218438B2/ja active Active
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2021
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2022
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CN113194931A (zh) | 2021-07-30 |
CN117281790A (zh) | 2023-12-26 |
AU2019404026B2 (en) | 2023-06-08 |
CA3121193A1 (en) | 2020-06-25 |
US11464764B2 (en) | 2022-10-11 |
EP3897589A1 (en) | 2021-10-27 |
PH12021551449A1 (en) | 2021-12-06 |
SG11202105770YA (en) | 2021-07-29 |
KR102657097B1 (ko) | 2024-04-15 |
US20200197372A1 (en) | 2020-06-25 |
AU2019404026A1 (en) | 2021-06-10 |
BR112021010461A2 (pt) | 2021-08-24 |
US20230032377A1 (en) | 2023-02-02 |
CN113194931B (zh) | 2023-11-10 |
EP3897589A4 (en) | 2022-10-12 |
JP7218438B2 (ja) | 2023-02-06 |
IL284061A (en) | 2021-08-31 |
NZ776354A (en) | 2023-03-31 |
KR20210094127A (ko) | 2021-07-28 |
WO2020132023A1 (en) | 2020-06-25 |
JP2022518356A (ja) | 2022-03-15 |
ZA202103561B (en) | 2022-11-30 |
CA3121193C (en) | 2024-03-12 |
CL2021001528A1 (es) | 2021-12-17 |
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