MX2021004568A - Inhibidores de cinasa heterociclicos y usos de los mismos. - Google Patents
Inhibidores de cinasa heterociclicos y usos de los mismos.Info
- Publication number
- MX2021004568A MX2021004568A MX2021004568A MX2021004568A MX2021004568A MX 2021004568 A MX2021004568 A MX 2021004568A MX 2021004568 A MX2021004568 A MX 2021004568A MX 2021004568 A MX2021004568 A MX 2021004568A MX 2021004568 A MX2021004568 A MX 2021004568A
- Authority
- MX
- Mexico
- Prior art keywords
- kinase inhibitors
- dasatinib
- inhibitors
- pharmaceutical compositions
- disorder
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 6
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 title 1
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 abstract 3
- 239000002067 L01XE06 - Dasatinib Substances 0.000 abstract 3
- 229960002448 dasatinib Drugs 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 abstract 1
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 abstract 1
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 238000011284 combination treatment Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 238000011269 treatment regimen Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18202164.2A EP3643713B1 (en) | 2018-10-23 | 2018-10-23 | Heterocyclic kinase inhibitors and uses thereof |
| PCT/EP2019/078751 WO2020083926A1 (en) | 2018-10-23 | 2019-10-22 | Heterocyclic kinase inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021004568A true MX2021004568A (es) | 2021-09-08 |
Family
ID=64270595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021004568A MX2021004568A (es) | 2018-10-23 | 2019-10-22 | Inhibidores de cinasa heterociclicos y usos de los mismos. |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US12172993B2 (https=) |
| EP (2) | EP3643713B1 (https=) |
| JP (1) | JP7667568B2 (https=) |
| KR (1) | KR20210081353A (https=) |
| CN (1) | CN112955447B (https=) |
| AU (1) | AU2019368654C1 (https=) |
| BR (1) | BR112021007643A2 (https=) |
| CA (1) | CA3116674A1 (https=) |
| DK (1) | DK3643713T3 (https=) |
| IL (1) | IL282588A (https=) |
| MX (1) | MX2021004568A (https=) |
| SG (1) | SG11202103142TA (https=) |
| WO (1) | WO2020083926A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020051424A1 (en) | 2018-09-07 | 2020-03-12 | Pic Therapeutics | Eif4e inhibitors and uses thereof |
| DK3643713T3 (da) | 2018-10-23 | 2025-11-03 | Iomx Therapeutics Ag | Heterocykliske kinaseinhibitorer og deres anvendelse |
| TW202146393A (zh) | 2020-03-03 | 2021-12-16 | 美商皮克醫療公司 | Eif4e抑制劑及其用途 |
| EP3901151B1 (en) * | 2020-04-21 | 2026-04-01 | iOmx Therapeutics AG | Halogenated-heteroaryl and other heterocyclic kinase inhibitors, and uses thereof |
| CN115398019B (zh) * | 2020-08-31 | 2023-07-07 | 日本制铁株式会社 | 钢板及其制造方法 |
| CA3229560A1 (en) | 2021-08-25 | 2023-03-02 | Christopher L. Vandeusen | Eif4e inhibitors and uses thereof |
| US12157732B2 (en) | 2021-08-25 | 2024-12-03 | PIC Therapeutics, Inc. | eIF4E inhibitors and uses thereof |
| JP2024539268A (ja) * | 2021-10-19 | 2024-10-28 | アイオーエムエックス セラピューティクス アーゲー | Ｓｉｋ３阻害剤及びその中間体を調製する合成スキーム及び手順 |
| CN116813608B (zh) * | 2023-06-08 | 2024-03-22 | 英矽智能科技(上海)有限公司 | 噻唑类化合物及其应用 |
| WO2025229127A1 (en) | 2024-04-30 | 2025-11-06 | Iomx Therapeutics Ag | A halogenated-heteroaryl kinase inhibitor for treating soft tissue sarcoma and vascular tumors |
| EP4643861A1 (en) | 2024-04-30 | 2025-11-05 | iOmx Therapeutics AG | A halogenated-heteroaryl kinase inhbitor for treating soft tissue sarcoma and vascular tumors |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4475916A (en) | 1982-03-18 | 1984-10-09 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| EP1169038B9 (en) | 1999-04-15 | 2013-07-10 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| US7125875B2 (en) * | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| CA2503715A1 (en) * | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Kinase inhibitors |
| TWI338004B (en) | 2004-02-06 | 2011-03-01 | Bristol Myers Squibb Co | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
| ES2377430T3 (es) * | 2004-09-02 | 2012-03-27 | Genentech, Inc. | Inhibidores piridílicos de la señalización de hedgehog |
| WO2006081172A2 (en) * | 2005-01-26 | 2006-08-03 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AU2007296743B2 (en) * | 2006-09-11 | 2012-02-16 | Curis, Inc. | Tyrosine kinase inhibitors containing a zinc binding moiety |
| US20090281089A1 (en) * | 2008-04-11 | 2009-11-12 | Genentech, Inc. | Pyridyl inhibitors of hedgehog signalling |
| US8907053B2 (en) | 2010-06-25 | 2014-12-09 | Aurigene Discovery Technologies Limited | Immunosuppression modulating compounds |
| WO2012040636A2 (en) * | 2010-09-24 | 2012-03-29 | The Broad Institute, Inc. | Compounds and methods for treating diseases mediated by protease activated receptors |
| US9255072B2 (en) | 2011-03-04 | 2016-02-09 | National Health Rsearch Institutes | Pyrazole compounds and thiazole compounds as protein kinases inhibitors |
| NZ702618A (en) * | 2012-06-27 | 2016-12-23 | 4Sc Discovery Gmbh | Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, autoimmuneinflammation and cns disorders |
| CN106699744B (zh) | 2015-11-18 | 2021-05-11 | 四川海思科制药有限公司 | 一种杂环类酰胺衍生物及其制备方法和在药学上的应用 |
| EP3391907B8 (en) * | 2017-04-20 | 2020-03-04 | iOmx Therapeutics AG | Intracellular kinase sik3 associated with resistance against anti-tumour immune responses, and uses thereof |
| US11274100B2 (en) | 2017-06-21 | 2022-03-15 | Daiichi Sankyo Company, Limited | EP300/CREBBP inhibitor |
| DK3643713T3 (da) | 2018-10-23 | 2025-11-03 | Iomx Therapeutics Ag | Heterocykliske kinaseinhibitorer og deres anvendelse |
| US20230212163A1 (en) | 2020-04-21 | 2023-07-06 | Bayer Aktiengesellschaft | 2-(het)aryl-substituted condensed heterocyclic derivatives as pest control agents |
| JP2024539268A (ja) | 2021-10-19 | 2024-10-28 | アイオーエムエックス セラピューティクス アーゲー | Ｓｉｋ３阻害剤及びその中間体を調製する合成スキーム及び手順 |
-
2018
- 2018-10-23 DK DK18202164.2T patent/DK3643713T3/da active
- 2018-10-23 EP EP18202164.2A patent/EP3643713B1/en active Active
-
2019
- 2019-10-22 US US17/286,178 patent/US12172993B2/en active Active
- 2019-10-22 KR KR1020217013282A patent/KR20210081353A/ko not_active Ceased
- 2019-10-22 WO PCT/EP2019/078751 patent/WO2020083926A1/en not_active Ceased
- 2019-10-22 CA CA3116674A patent/CA3116674A1/en active Pending
- 2019-10-22 SG SG11202103142TA patent/SG11202103142TA/en unknown
- 2019-10-22 BR BR112021007643-3A patent/BR112021007643A2/pt unknown
- 2019-10-22 CN CN201980069736.5A patent/CN112955447B/zh active Active
- 2019-10-22 JP JP2021522057A patent/JP7667568B2/ja active Active
- 2019-10-22 AU AU2019368654A patent/AU2019368654C1/en active Active
- 2019-10-22 EP EP19787302.9A patent/EP3870580A1/en active Pending
- 2019-10-22 MX MX2021004568A patent/MX2021004568A/es unknown
-
2021
- 2021-04-22 IL IL282588A patent/IL282588A/en unknown
-
2024
- 2024-11-26 US US18/961,194 patent/US20250101015A1/en active Pending
- 2024-11-26 US US18/961,176 patent/US20250084076A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210081353A (ko) | 2021-07-01 |
| EP3643713B1 (en) | 2025-07-30 |
| DK3643713T3 (da) | 2025-11-03 |
| US20210387982A1 (en) | 2021-12-16 |
| EP3643713A1 (en) | 2020-04-29 |
| WO2020083926A1 (en) | 2020-04-30 |
| CN112955447A (zh) | 2021-06-11 |
| SG11202103142TA (en) | 2021-05-28 |
| AU2019368654A1 (en) | 2021-05-06 |
| US20250084076A1 (en) | 2025-03-13 |
| EP3870580A1 (en) | 2021-09-01 |
| CN112955447B (zh) | 2025-09-09 |
| AU2019368654C1 (en) | 2025-06-19 |
| CA3116674A1 (en) | 2020-04-30 |
| JP2022505645A (ja) | 2022-01-14 |
| IL282588A (en) | 2021-06-30 |
| BR112021007643A2 (pt) | 2021-07-27 |
| US20250101015A1 (en) | 2025-03-27 |
| US12172993B2 (en) | 2024-12-24 |
| JP7667568B2 (ja) | 2025-04-23 |
| AU2019368654B2 (en) | 2025-02-27 |
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