BR112021007643A2 - inibidores heterocíclicos de quinase e seus usos - Google Patents

inibidores heterocíclicos de quinase e seus usos Download PDF

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Publication number
BR112021007643A2
BR112021007643A2 BR112021007643-3A BR112021007643A BR112021007643A2 BR 112021007643 A2 BR112021007643 A2 BR 112021007643A2 BR 112021007643 A BR112021007643 A BR 112021007643A BR 112021007643 A2 BR112021007643 A2 BR 112021007643A2
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BR
Brazil
Prior art keywords
alkyl
group
independently selected
optionally substituted
ethyl
Prior art date
Application number
BR112021007643-3A
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English (en)
Portuguese (pt)
Inventor
Peter Sennhenn
Sebastian Meier-Ewert
Nisit Khandelwal
David Bancroft
Original Assignee
Iomx Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iomx Therapeutics Ag filed Critical Iomx Therapeutics Ag
Publication of BR112021007643A2 publication Critical patent/BR112021007643A2/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
BR112021007643-3A 2018-10-23 2019-10-22 inibidores heterocíclicos de quinase e seus usos BR112021007643A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18202164.2A EP3643713B1 (en) 2018-10-23 2018-10-23 Heterocyclic kinase inhibitors and uses thereof
EP18202164.2 2018-10-23
PCT/EP2019/078751 WO2020083926A1 (en) 2018-10-23 2019-10-22 Heterocyclic kinase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
BR112021007643A2 true BR112021007643A2 (pt) 2021-07-27

Family

ID=64270595

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021007643-3A BR112021007643A2 (pt) 2018-10-23 2019-10-22 inibidores heterocíclicos de quinase e seus usos

Country Status (13)

Country Link
US (3) US12172993B2 (https=)
EP (2) EP3643713B1 (https=)
JP (1) JP7667568B2 (https=)
KR (1) KR20210081353A (https=)
CN (1) CN112955447B (https=)
AU (1) AU2019368654C1 (https=)
BR (1) BR112021007643A2 (https=)
CA (1) CA3116674A1 (https=)
DK (1) DK3643713T3 (https=)
IL (1) IL282588A (https=)
MX (1) MX2021004568A (https=)
SG (1) SG11202103142TA (https=)
WO (1) WO2020083926A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020051424A1 (en) 2018-09-07 2020-03-12 Pic Therapeutics Eif4e inhibitors and uses thereof
DK3643713T3 (da) 2018-10-23 2025-11-03 Iomx Therapeutics Ag Heterocykliske kinaseinhibitorer og deres anvendelse
TW202146393A (zh) 2020-03-03 2021-12-16 美商皮克醫療公司 Eif4e抑制劑及其用途
EP3901151B1 (en) * 2020-04-21 2026-04-01 iOmx Therapeutics AG Halogenated-heteroaryl and other heterocyclic kinase inhibitors, and uses thereof
CN115398019B (zh) * 2020-08-31 2023-07-07 日本制铁株式会社 钢板及其制造方法
CA3229560A1 (en) 2021-08-25 2023-03-02 Christopher L. Vandeusen Eif4e inhibitors and uses thereof
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
JP2024539268A (ja) * 2021-10-19 2024-10-28 アイオーエムエックス セラピューティクス アーゲー Sik3阻害剤及びその中間体を調製する合成スキーム及び手順
CN116813608B (zh) * 2023-06-08 2024-03-22 英矽智能科技(上海)有限公司 噻唑类化合物及其应用
WO2025229127A1 (en) 2024-04-30 2025-11-06 Iomx Therapeutics Ag A halogenated-heteroaryl kinase inhibitor for treating soft tissue sarcoma and vascular tumors
EP4643861A1 (en) 2024-04-30 2025-11-05 iOmx Therapeutics AG A halogenated-heteroaryl kinase inhbitor for treating soft tissue sarcoma and vascular tumors

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JP2024539268A (ja) 2021-10-19 2024-10-28 アイオーエムエックス セラピューティクス アーゲー Sik3阻害剤及びその中間体を調製する合成スキーム及び手順

Also Published As

Publication number Publication date
KR20210081353A (ko) 2021-07-01
EP3643713B1 (en) 2025-07-30
DK3643713T3 (da) 2025-11-03
US20210387982A1 (en) 2021-12-16
EP3643713A1 (en) 2020-04-29
WO2020083926A1 (en) 2020-04-30
CN112955447A (zh) 2021-06-11
SG11202103142TA (en) 2021-05-28
AU2019368654A1 (en) 2021-05-06
US20250084076A1 (en) 2025-03-13
EP3870580A1 (en) 2021-09-01
CN112955447B (zh) 2025-09-09
AU2019368654C1 (en) 2025-06-19
CA3116674A1 (en) 2020-04-30
JP2022505645A (ja) 2022-01-14
MX2021004568A (es) 2021-09-08
IL282588A (en) 2021-06-30
US20250101015A1 (en) 2025-03-27
US12172993B2 (en) 2024-12-24
JP7667568B2 (ja) 2025-04-23
AU2019368654B2 (en) 2025-02-27

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