MX2021004056A - Cepa de akkermansia muciniphila y uso de la misma. - Google Patents
Cepa de akkermansia muciniphila y uso de la misma.Info
- Publication number
- MX2021004056A MX2021004056A MX2021004056A MX2021004056A MX2021004056A MX 2021004056 A MX2021004056 A MX 2021004056A MX 2021004056 A MX2021004056 A MX 2021004056A MX 2021004056 A MX2021004056 A MX 2021004056A MX 2021004056 A MX2021004056 A MX 2021004056A
- Authority
- MX
- Mexico
- Prior art keywords
- alleviation
- prevention
- improvement
- treatment
- composition
- Prior art date
Links
- 241000702462 Akkermansia muciniphila Species 0.000 title abstract 2
- 235000021407 appetite control Nutrition 0.000 abstract 4
- 208000030159 metabolic disease Diseases 0.000 abstract 3
- 230000002265 prevention Effects 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 230000028327 secretion Effects 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 210000003486 adipose tissue brown Anatomy 0.000 abstract 1
- 230000003579 anti-obesity Effects 0.000 abstract 1
- 230000014101 glucose homeostasis Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21102—C-terminal processing peptidase (3.4.21.102)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/332—Promoters of weight control and weight loss
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
Abstract
La presente invención se relaciona a la cepa SNUG-61027 de Akkermansia muciniphila (número de acceso KCTC 13530BP) y uso de la misma, específicamente, se proporcionan una composición para suprimir el apetito o prevenir, aminorar, aliviar o tratar enfermedades metabólicas, que comprende la cepa, o una solución de cultivo de la misma, etc. O un aislado de proteína B2UM07 de la misma como un ingrediente activo, y uso de la misma para suprimir el apetito o prevenir, aminorar, aliviar o tratar enfermedades metabólicas, y un método para suprimir el apetito o prevenir, aminorar, aliviar o tratar enfermedades metabólicas usando la misma. A través de esto, entre los efectos anti-obesidad, se exhiben no únicamente la reducción de peso y regulación de homeostasis de glucosa, sino también el efecto en la grasa café y el efecto de secretar hormonas reguladoras del apetito.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20180121137 | 2018-10-11 | ||
KR1020190125670A KR102197180B1 (ko) | 2018-10-11 | 2019-10-10 | 아커만시아 뮤시니필라 균주 및 이를 포함하는 식욕 억제 및 대사성 질환 예방, 개선, 완화 및 치료용 조성물 |
PCT/KR2019/013402 WO2020076136A2 (ko) | 2018-10-11 | 2019-10-11 | 아커만시아 뮤시니필라 균주 및 이의 용도 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021004056A true MX2021004056A (es) | 2021-06-04 |
Family
ID=70456542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021004056A MX2021004056A (es) | 2018-10-11 | 2019-10-11 | Cepa de akkermansia muciniphila y uso de la misma. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20220002665A1 (es) |
EP (1) | EP3865568A4 (es) |
JP (1) | JP7185036B2 (es) |
KR (1) | KR102197180B1 (es) |
CN (1) | CN113330109B (es) |
AU (1) | AU2019356410B2 (es) |
BR (1) | BR112021006855A2 (es) |
CA (1) | CA3115196A1 (es) |
MX (1) | MX2021004056A (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102197180B1 (ko) * | 2018-10-11 | 2020-12-31 | 주식회사 고바이오랩 | 아커만시아 뮤시니필라 균주 및 이를 포함하는 식욕 억제 및 대사성 질환 예방, 개선, 완화 및 치료용 조성물 |
WO2021215828A1 (ko) * | 2020-04-24 | 2021-10-28 | 주식회사 고바이오랩 | Glp-1 유도 활성을 갖는 단백질 변이체 및 이의 용도 |
KR20210149366A (ko) * | 2020-06-02 | 2021-12-09 | 주식회사 고바이오랩 | Icam-2에 결합하는 물질을 유효성분으로 포함하는 대사질환 예방 또는 치료용 약학 조성물 |
KR102222953B1 (ko) * | 2020-11-11 | 2021-03-04 | 주식회사 엔테로바이옴 | 난배양성 혐기성 미생물의 고수율 배양을 위한 배지 보충제 및 그를 포함하는 배지 조성물 |
CA3132176C (en) | 2020-11-11 | 2023-03-14 | Enterobiome Inc. | Medium supplement for high-yield industrial culture of fastidious anaerobes and medium composition containing the same |
CN113322202B (zh) * | 2021-05-31 | 2022-03-01 | 君维安(武汉)生命科技有限公司 | 一种阿克曼氏菌、其培养方法及其应用 |
CN117957007A (zh) * | 2021-07-20 | 2024-04-30 | 鲁汶大学 | 奖励失调病症的预防和/或治疗 |
CN113862193B (zh) * | 2021-10-28 | 2023-12-22 | 江西普瑞森基因科技有限公司 | 一株嗜黏蛋白阿克曼氏菌及其在制备抗肿瘤药物中的应用 |
CN114456232B (zh) * | 2021-11-09 | 2023-09-29 | 中国科学院动物研究所 | 抑制饮食性肥胖的药物及其所用多肽 |
CN114569638B (zh) * | 2022-03-03 | 2023-06-13 | 中国农业大学 | 嗜黏蛋白阿克曼氏菌微生态制剂及其在蛋鸡上的应用 |
CN114796285B (zh) * | 2022-04-29 | 2023-06-23 | 大连工业大学 | 嗜黏蛋白阿克曼氏菌在缓解高尿酸血症中的应用 |
CN114949002B (zh) * | 2022-06-08 | 2024-03-19 | 广州知易生物科技有限公司 | 嗜粘蛋白阿克曼菌在制备防治动脉粥样硬化的组合物中的应用 |
CN115252651B (zh) * | 2022-06-08 | 2024-06-07 | 广州知易生物科技有限公司 | 嗜粘蛋白阿克曼菌在制备防治高血压的组合物中的应用和含有其的组合物 |
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CN115975885B (zh) * | 2022-12-23 | 2024-07-16 | 中国农业大学 | 一种利用鱼加工副产物为氮源的嗜黏蛋白阿克曼菌培养基的制备 |
EP4444918A1 (en) * | 2023-02-28 | 2024-10-16 | Enterobiome Inc. | Method for predicting therapeutic response of pharmabiotics and treatment method of various diseases using the same |
CN116999468A (zh) * | 2023-08-18 | 2023-11-07 | 善恩康生物科技(苏州)有限公司 | Akkermansia muciniphila在制备预防、治疗和/或辅助治疗心血管疾病的产品中的应用 |
CN117756898A (zh) * | 2023-12-04 | 2024-03-26 | 河南师范大学 | 重组表达阿克曼氏菌Amuc_1631蛋白及其应用 |
CN117603884B (zh) * | 2024-01-17 | 2024-03-26 | 广州同康生物科技有限公司 | 一种嗜黏蛋白阿克曼氏菌菌粉及其制备方法 |
CN117946949B (zh) * | 2024-03-26 | 2024-06-07 | 四川厌氧生物科技有限责任公司 | 一种嗜黏蛋白阿克曼氏菌及其用途 |
CN117965391B (zh) * | 2024-03-27 | 2024-06-07 | 四川厌氧生物科技有限责任公司 | 一种嗜黏蛋白阿克曼氏菌Amuci-1及其用途 |
CN118207140B (zh) * | 2024-05-20 | 2024-09-17 | 微康益生菌(苏州)股份有限公司 | 一种具有调节血糖血脂功效的嗜粘蛋白阿克曼氏菌Akk11及其应用 |
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WO2014075745A1 (en) * | 2012-11-19 | 2014-05-22 | Université Catholique de Louvain | Use of akkermansia for treating metabolic disorders |
EP3967315A1 (en) * | 2012-11-19 | 2022-03-16 | Université catholique de Louvain | Use of akkermansia for treating metabolic disorders |
WO2015178653A1 (ko) * | 2014-05-20 | 2015-11-26 | 이화여자대학교 산학협력단 | Akkermansia muciniphila 균에서 유래하는 세포밖 소포를 유효성분으로 함유하는 대사질환의 치료 또는 예방용 조성물 |
KR101740893B1 (ko) | 2014-05-20 | 2017-06-13 | 주식회사 엠디헬스케어 | Akkermansia muciniphila 균에서 유래하는 세포밖 소포를 유효성분으로 함유하는 대사질환의 치료 또는 예방용 조성물 |
CA2984985A1 (en) | 2015-05-06 | 2016-11-10 | Universite Catholique De Louvain | Use of a polypeptide for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status |
KR20240001261A (ko) * | 2015-05-06 | 2024-01-03 | 바게닝겐 유니버시테이트 | 아커만시아의 배양 방법 |
CN114276960A (zh) * | 2015-09-10 | 2022-04-05 | 卢万天主教大学 | 经巴氏灭菌的艾克曼菌用于治疗代谢病症的用途 |
WO2017060698A1 (en) | 2015-10-05 | 2017-04-13 | Liam O'mahony | Use of akkermansia muciniphila for treating inflammatory conditions |
KR101809172B1 (ko) * | 2016-07-11 | 2017-12-14 | 한국생명공학연구원 | 뮤신이 없는 배지에서 배양한 아커만시아 뮤시니필라 균주 또는 이의 배양액을 유효성분으로 함유하는 대사성 질환의 예방, 개선 또는 치료용 조성물 |
CN106176800B (zh) * | 2016-07-11 | 2019-12-06 | 韩源平 | 多聚阳离子树脂的制药应用 |
US20200030388A1 (en) * | 2017-06-15 | 2020-01-30 | Muhammed Majeed | Compositions for modifying gut microbiota |
KR102197180B1 (ko) * | 2018-10-11 | 2020-12-31 | 주식회사 고바이오랩 | 아커만시아 뮤시니필라 균주 및 이를 포함하는 식욕 억제 및 대사성 질환 예방, 개선, 완화 및 치료용 조성물 |
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2019
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- 2019-10-11 US US17/279,247 patent/US20220002665A1/en active Pending
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- 2019-10-11 AU AU2019356410A patent/AU2019356410B2/en active Active
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JP7185036B2 (ja) | 2022-12-06 |
KR102197180B1 (ko) | 2020-12-31 |
CN113330109A (zh) | 2021-08-31 |
EP3865568A2 (en) | 2021-08-18 |
AU2019356410B2 (en) | 2023-07-06 |
BR112021006855A2 (pt) | 2021-08-10 |
CA3115196A1 (en) | 2020-04-16 |
KR20200041280A (ko) | 2020-04-21 |
CN113330109B (zh) | 2024-02-09 |
RU2021135116A3 (es) | 2022-04-29 |
US20220002665A1 (en) | 2022-01-06 |
EP3865568A4 (en) | 2022-08-17 |
RU2021135116A (ru) | 2021-12-06 |
JP2022502067A (ja) | 2022-01-11 |
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