MX2021004036A - Anticuerpos biespecíficos dirigidos a exosomas. - Google Patents
Anticuerpos biespecíficos dirigidos a exosomas.Info
- Publication number
- MX2021004036A MX2021004036A MX2021004036A MX2021004036A MX2021004036A MX 2021004036 A MX2021004036 A MX 2021004036A MX 2021004036 A MX2021004036 A MX 2021004036A MX 2021004036 A MX2021004036 A MX 2021004036A MX 2021004036 A MX2021004036 A MX 2021004036A
- Authority
- MX
- Mexico
- Prior art keywords
- bispecific antibodies
- exosome
- targeting
- associated protein
- targeting bispecific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Los inventos descritos en el presente documento están enfocados a anticuerpos biespecíficos que son capaces de dirigirse selectivamente a exosomas, uniendo específicamente una primera proteína asociada a exosoma y al ligando 1 de muerte programada ("PD-L1") como una segunda proteína asociada a exosoma. Estos anticuerpos biespecíficos pueden interrumpir la supresión de la actividad antitumoral por parte de las células inmunitarias al dirigirse a exosomas derivados de células tumorales que inhiben la activación de las células T. Por tanto, los anticuerpos biespecíficos del invento pueden utilizarse en métodos para tratar cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862746862P | 2018-10-17 | 2018-10-17 | |
PCT/US2019/056698 WO2020081786A1 (en) | 2018-10-17 | 2019-10-17 | Exosome-targeting bispecific antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021004036A true MX2021004036A (es) | 2021-08-24 |
Family
ID=70284767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021004036A MX2021004036A (es) | 2018-10-17 | 2019-10-17 | Anticuerpos biespecíficos dirigidos a exosomas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20210347895A1 (es) |
EP (1) | EP3866851A4 (es) |
KR (1) | KR20210091714A (es) |
CN (1) | CN113423425A (es) |
AU (1) | AU2019359877A1 (es) |
BR (1) | BR112021007469A2 (es) |
CA (1) | CA3116560A1 (es) |
IL (1) | IL282355A (es) |
MX (1) | MX2021004036A (es) |
SG (1) | SG11202103812RA (es) |
WO (1) | WO2020081786A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2021003779A (es) | 2018-10-02 | 2021-09-21 | Immunome Inc | Anticuerpos dirigidos a la epn1. |
CN114354913A (zh) * | 2021-12-31 | 2022-04-15 | 厦门大学 | 一种外泌体pd-l1糖基化检测方法 |
CN114990129B (zh) * | 2022-05-11 | 2023-02-03 | 北京贝来生物科技有限公司 | 表达αPDL1:Fc融合蛋白的间充质干细胞的制备及应用 |
WO2023225613A2 (en) * | 2022-05-18 | 2023-11-23 | Immunome, Inc. | Combination anti-epn1 and anti-pd-l1 antibody therapies |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160145355A1 (en) * | 2013-06-24 | 2016-05-26 | Biomed Valley Discoveries, Inc. | Bispecific antibodies |
EP4141032B1 (en) * | 2014-11-20 | 2024-05-29 | F. Hoffmann-La Roche AG | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists |
RU2018105846A (ru) * | 2015-07-29 | 2019-08-28 | Новартис Аг | Комбинация антагониста pd-1 с ингибитором egfr |
WO2017087280A1 (en) * | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
CU24613B1 (es) * | 2016-02-06 | 2022-07-08 | Epimab Biotherapeutics Inc | Proteínas de unión a inmunoglobulinas fabs en tandem (fit-ig) biespecíficas que se unen a cmet y egfr |
DK3433273T3 (da) * | 2016-03-25 | 2022-02-14 | Biomunex Pharmaceuticals | Binding af molekyler til cd38 og pd-l1 |
CN108250302A (zh) * | 2016-12-29 | 2018-07-06 | 天津天锐生物科技有限公司 | 一种多功能蛋白质 |
-
2019
- 2019-10-17 SG SG11202103812RA patent/SG11202103812RA/en unknown
- 2019-10-17 AU AU2019359877A patent/AU2019359877A1/en active Pending
- 2019-10-17 US US17/283,614 patent/US20210347895A1/en active Pending
- 2019-10-17 CN CN201980081663.1A patent/CN113423425A/zh active Pending
- 2019-10-17 WO PCT/US2019/056698 patent/WO2020081786A1/en unknown
- 2019-10-17 EP EP19872880.0A patent/EP3866851A4/en active Pending
- 2019-10-17 MX MX2021004036A patent/MX2021004036A/es unknown
- 2019-10-17 BR BR112021007469-4A patent/BR112021007469A2/pt unknown
- 2019-10-17 CA CA3116560A patent/CA3116560A1/en active Pending
- 2019-10-17 KR KR1020217014855A patent/KR20210091714A/ko active Search and Examination
-
2021
- 2021-04-14 IL IL282355A patent/IL282355A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3866851A4 (en) | 2022-11-02 |
CN113423425A (zh) | 2021-09-21 |
EP3866851A1 (en) | 2021-08-25 |
WO2020081786A1 (en) | 2020-04-23 |
KR20210091714A (ko) | 2021-07-22 |
IL282355A (en) | 2021-05-31 |
BR112021007469A2 (pt) | 2021-08-10 |
AU2019359877A1 (en) | 2021-05-20 |
JP2022512734A (ja) | 2022-02-07 |
CA3116560A1 (en) | 2020-04-23 |
SG11202103812RA (en) | 2021-05-28 |
US20210347895A1 (en) | 2021-11-11 |
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