MX2021002295A - Variantes de proteinas recombinantes. - Google Patents
Variantes de proteinas recombinantes.Info
- Publication number
- MX2021002295A MX2021002295A MX2021002295A MX2021002295A MX2021002295A MX 2021002295 A MX2021002295 A MX 2021002295A MX 2021002295 A MX2021002295 A MX 2021002295A MX 2021002295 A MX2021002295 A MX 2021002295A MX 2021002295 A MX2021002295 A MX 2021002295A
- Authority
- MX
- Mexico
- Prior art keywords
- amino acid
- acid modification
- recombinant protein
- protein variants
- acid sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- C07K14/42—Lectins, e.g. concanavalin, phytohaemagglutinin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/178—Lectin superfamily, e.g. selectins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4726—Lectins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporciona una proteína lectina modificada que tiene al menos una modificación de aminoácido en una secuencia de aminoácidos de la SEQ ID NO. 1 o en una secuencia de aminoácidos que tiene al menos 60 % de homología con esta. La modificación de aminoácido se selecciona de uno o más de los siguientes: al menos una modificación de aminoácido en un sitio de unión del carbohidrato; 5 al menos una modificación de aminoácido en el extremo N-terminal; al menos una modificación de aminoácido en la posición 76; o al menos una modificación de aminoácido en la posición 44 u 89. La proteína lectina modificada no consiste en la secuencia de aminoácidos de ninguna de las SEQ ID NO: 2 a 4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201821032765 | 2018-08-31 | ||
| PCT/IB2019/057314 WO2020044296A2 (en) | 2018-08-31 | 2019-08-30 | Recombinant protein variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021002295A true MX2021002295A (es) | 2021-04-28 |
Family
ID=68344911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021002295A MX2021002295A (es) | 2018-08-31 | 2019-08-30 | Variantes de proteinas recombinantes. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11965003B2 (es) |
| EP (1) | EP3844183A2 (es) |
| JP (1) | JP7453213B2 (es) |
| KR (1) | KR20210052449A (es) |
| CN (1) | CN113383015B (es) |
| AU (1) | AU2019330367A1 (es) |
| BR (1) | BR112021003628A2 (es) |
| CA (1) | CA3108842A1 (es) |
| EA (1) | EA202190240A1 (es) |
| MA (1) | MA53498A (es) |
| MX (1) | MX2021002295A (es) |
| SG (1) | SG11202101391WA (es) |
| WO (1) | WO2020044296A2 (es) |
| ZA (1) | ZA202100859B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11202112726SA (en) * | 2019-07-09 | 2021-12-30 | Unichem Lab Ltd | Stable formulations of recombinant proteins |
| AU2021267196A1 (en) | 2020-05-07 | 2023-01-05 | Unichem Laboratories Ltd | Anti-cancer proteins |
| BR112023013635A2 (pt) * | 2021-01-07 | 2023-12-05 | Unichem Lab Ltd | Proteína lectina para tratamento e prevenção de doenças neurodegenerativas |
| CA3223964A1 (en) | 2021-07-08 | 2023-01-12 | Dhananjay Sathe | Recombinant proteins, compositions and methods of stabilization thereof |
| AU2022336409A1 (en) * | 2021-08-30 | 2024-02-15 | Unichem Laboratories Limited | Protein compositions for the treatment of inflammatory diseases |
| KR20240067065A (ko) | 2021-10-01 | 2024-05-16 | 유니켐 레버러토리스 리미티드 | 재조합 글리칸 결합 단백질 및 이의 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2430041T3 (en) | 2009-02-18 | 2019-02-25 | Unichem Lab Ltd | RECOMBINANT LECTINES BINDING TO CANCER CELLS WITH ANTITUMOR ACTIVITY AND PREPARATION METHOD |
| WO2014203261A2 (en) * | 2010-02-02 | 2014-12-24 | Unichem Laboratories Ltd. | Recombinant lectin and method of preparing thereof |
| KR101924673B1 (ko) * | 2011-11-01 | 2018-12-03 | 내셔날 인스티튜트 오브 어드밴스드 인더스트리얼 사이언스 앤드 테크놀로지 | 미분화 세포 검출 방법 및 복합 당질 검출 방법 |
| EP3048904A2 (en) * | 2013-09-25 | 2016-08-03 | Pronutria Biosciences, Inc. | Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof |
| WO2015054507A1 (en) * | 2013-10-10 | 2015-04-16 | Pronutria, Inc. | Nutritive polypeptide production systems, and methods of manufacture and use thereof |
-
2019
- 2019-08-30 AU AU2019330367A patent/AU2019330367A1/en active Pending
- 2019-08-30 MX MX2021002295A patent/MX2021002295A/es unknown
- 2019-08-30 WO PCT/IB2019/057314 patent/WO2020044296A2/en unknown
- 2019-08-30 EA EA202190240A patent/EA202190240A1/ru unknown
- 2019-08-30 CN CN201980054953.7A patent/CN113383015B/zh active Active
- 2019-08-30 CA CA3108842A patent/CA3108842A1/en active Pending
- 2019-08-30 US US17/272,090 patent/US11965003B2/en active Active
- 2019-08-30 MA MA053498A patent/MA53498A/fr unknown
- 2019-08-30 SG SG11202101391WA patent/SG11202101391WA/en unknown
- 2019-08-30 EP EP19794640.3A patent/EP3844183A2/en active Pending
- 2019-08-30 KR KR1020217005356A patent/KR20210052449A/ko unknown
- 2019-08-30 BR BR112021003628-8A patent/BR112021003628A2/pt unknown
- 2019-08-30 JP JP2021510408A patent/JP7453213B2/ja active Active
-
2021
- 2021-02-08 ZA ZA2021/00859A patent/ZA202100859B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP7453213B2 (ja) | 2024-03-19 |
| CN113383015B (zh) | 2023-06-20 |
| EP3844183A2 (en) | 2021-07-07 |
| US20210317171A1 (en) | 2021-10-14 |
| WO2020044296A2 (en) | 2020-03-05 |
| MA53498A (fr) | 2021-07-07 |
| CA3108842A1 (en) | 2020-03-05 |
| EA202190240A1 (ru) | 2021-08-09 |
| KR20210052449A (ko) | 2021-05-10 |
| JP2021534776A (ja) | 2021-12-16 |
| CN113383015A (zh) | 2021-09-10 |
| BR112021003628A2 (pt) | 2021-05-18 |
| WO2020044296A3 (en) | 2020-04-23 |
| US11965003B2 (en) | 2024-04-23 |
| AU2019330367A1 (en) | 2021-03-11 |
| ZA202100859B (en) | 2022-07-27 |
| SG11202101391WA (en) | 2021-03-30 |
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