MX2021001827A - Composiciones de trombina liquida estable. - Google Patents

Composiciones de trombina liquida estable.

Info

Publication number
MX2021001827A
MX2021001827A MX2021001827A MX2021001827A MX2021001827A MX 2021001827 A MX2021001827 A MX 2021001827A MX 2021001827 A MX2021001827 A MX 2021001827A MX 2021001827 A MX2021001827 A MX 2021001827A MX 2021001827 A MX2021001827 A MX 2021001827A
Authority
MX
Mexico
Prior art keywords
liquid thrombin
stable liquid
glycerol
compositions
thrombin compositions
Prior art date
Application number
MX2021001827A
Other languages
English (en)
Inventor
Omri Faingold
Erez Ilan
Sivan Doron
Original Assignee
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omrix Biopharmaceuticals Ltd filed Critical Omrix Biopharmaceuticals Ltd
Publication of MX2021001827A publication Critical patent/MX2021001827A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención proporciona métodos para la preparación a gran escala de una composición de trombina líquida estable estéril compuesta de glicerol; composiciones de trombina líquida estable; y composición y kits hemostáticos; la presente invención proporciona además composiciones hemostáticas compuestas de trombina líquida, glicerol y gelatina; en la presente descripción se proporciona además un método para la producción a gran escala de una composición de trombina líquida estéril que comprende glicerol.
MX2021001827A 2018-08-16 2019-08-08 Composiciones de trombina liquida estable. MX2021001827A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862764856P 2018-08-16 2018-08-16
IL261190A IL261190A (en) 2018-08-16 2018-08-16 Stable liquid preparations of thrombin
PCT/IL2019/000002 WO2020035848A2 (en) 2018-08-16 2019-08-08 Stable liquid thrombin compositions

Publications (1)

Publication Number Publication Date
MX2021001827A true MX2021001827A (es) 2021-04-28

Family

ID=66624845

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021001827A MX2021001827A (es) 2018-08-16 2019-08-08 Composiciones de trombina liquida estable.

Country Status (11)

Country Link
US (2) US11911448B2 (es)
EP (1) EP3836896A2 (es)
JP (1) JP7387715B2 (es)
KR (1) KR20210046699A (es)
CN (1) CN112566624A (es)
AU (1) AU2019321775A1 (es)
BR (1) BR112021002705A2 (es)
CA (1) CA3108744A1 (es)
IL (2) IL261190A (es)
MX (1) MX2021001827A (es)
WO (1) WO2020035848A2 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113144277B (zh) * 2021-04-13 2022-06-14 武汉理工大学 一种可注射流体明胶及其制备方法和应用
CA3216397A1 (en) * 2021-04-14 2022-10-20 Guangzhou Bioseal Biotech Co., Ltd. Flowable hemostatic paste
CN114377189B (zh) * 2021-12-10 2023-04-07 广东省科学院健康医学研究所 一种止血复合水凝胶及其制备方法与应用
CN118434458A (zh) 2021-12-21 2024-08-02 奥姆里克斯生物药品有限公司 包含纤维蛋白原的制剂及其用途
CN115400209A (zh) * 2022-10-19 2022-11-29 昆山博青生物科技有限公司 复合生物酶及含有该复合生物酶的敷料制剂、微囊制剂

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JPS5739849A (en) * 1980-06-30 1982-03-05 Apuraido Medical Debaishizu In Prepared bandage having coagulant composition and method
AT379311B (de) 1984-03-29 1985-12-27 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US4696812A (en) 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
US4965203A (en) 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
ZA88227B (en) * 1987-01-28 1988-06-30 Warner-Lambert Company Thrombin preparations
DE3725552A1 (de) 1987-08-01 1989-02-09 Hoechst Ag Spruehkopf zum applizieren eines mehrkomponentenmaterials mittels gas
US5116315A (en) 1989-10-03 1992-05-26 Hemaedics, Inc. Biological syringe system
EP0534178B1 (en) 1991-09-27 2001-04-18 Omrix Biopharmaceuticals S.A. Improved tissue glue prepared by using cryoprecipitate
EP0634140B2 (en) 1992-09-26 2004-08-04 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Applicator for tissue adhesive
AT400304B (de) 1994-02-28 1995-12-27 Immuno Ag Vorrichtung zur applikation eines mehrkomponenten-gewebeklebstoffes
DE69629010T2 (de) 1995-01-16 2004-04-15 Baxter International Inc., Deerfield Selbsttragende flächengebilde aus vernetztem fibrin zur hemmung von postoperativen adhäsionen
CA2222426A1 (en) 1995-06-06 1996-12-12 Andrew G. Hood, Iii Wound sealant preparation and application device and method
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
EP0856317A1 (en) 1997-01-31 1998-08-05 Omrix Biopharmaceuticals S.A. A stabilized mixture comprising fibrinogen
US6121232A (en) 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
JP2002514960A (ja) * 1997-06-18 2002-05-21 コヘージョン テクノロジーズ，インコーポレイテッド トロンビンおよびミクロフィブリルコラーゲンを含む組成物、ならびにその調製および使用の方法
US6461361B1 (en) 1998-05-01 2002-10-08 Baxter International Inc. Gas-driven spraying of mixed sealant agents
ATA49899A (de) 1999-03-19 2002-06-15 Immuno Ag Verfahren und vorrichtung zum mischen von komponenten
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WO2006009989A1 (en) * 2004-06-22 2006-01-26 Zymogenetics, Inc. Thrombin compositions
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ES2321639T3 (es) 2005-11-22 2009-06-09 Omrix Biopharmaceuticals S.A. Dispositivo aplicador para aplicar un fluido multicomponente.
JP5805542B2 (ja) 2009-02-20 2015-11-04 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． 少なくとも２成分の薬物を投与する装置
EP2977066A3 (en) 2012-06-12 2016-07-27 Ferrosan Medical Devices A/S Dry haemostatic composition
JP6193067B2 (ja) 2012-09-20 2017-09-06 三洋化成工業株式会社 外科用止血材基材及び外科用止血材
JP6810052B2 (ja) * 2015-03-27 2021-01-06 スリーエム イノベイティブ プロパティズ カンパニー フィブリン組成物、方法及び創傷物品

Also Published As

Publication number Publication date
US20240173388A1 (en) 2024-05-30
CA3108744A1 (en) 2020-02-20
IL261190A (en) 2019-01-31
KR20210046699A (ko) 2021-04-28
US20200054720A1 (en) 2020-02-20
JP2021534171A (ja) 2021-12-09
WO2020035848A2 (en) 2020-02-20
BR112021002705A2 (pt) 2021-05-11
JP7387715B2 (ja) 2023-11-28
CN112566624A (zh) 2021-03-26
IL280625A (en) 2021-03-25
AU2019321775A1 (en) 2021-02-25
US11911448B2 (en) 2024-02-27
WO2020035848A3 (en) 2020-04-23
EP3836896A2 (en) 2021-06-23

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