MX2021001547A - Constructo de acido nucleico recombinante. - Google Patents
Constructo de acido nucleico recombinante.Info
- Publication number
- MX2021001547A MX2021001547A MX2021001547A MX2021001547A MX2021001547A MX 2021001547 A MX2021001547 A MX 2021001547A MX 2021001547 A MX2021001547 A MX 2021001547A MX 2021001547 A MX2021001547 A MX 2021001547A MX 2021001547 A MX2021001547 A MX 2021001547A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- utr
- acid construct
- recombinant nucleic
- gene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/80—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates
- C12N2810/85—Vectors comprising as targeting moiety peptide derived from defined protein from vertebrates mammalian
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención está relacionada con un constructo de ácido nucleico recombinante que comprende en la dirección 5'-> 3' - una 5' UTR, - una región codificante que codifica una molécula efectora, y - una 3' UTR, en donde la 5' UTR se selecciona del grupo que comprende una 5' UTR de un gen o un derivado del mismo que tiene una identidad de nucleótidos de al menos 85%, en donde el gen se selecciona del grupo que consiste en MCP-1, RPL12 s.c., Ang-2, HSP70, H3.3., Galectina-9, GADD34, EDNI, HSP70m5, E-selectina, ICAM-1, IL-6 y vWF.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18188489.1A EP3608426A1 (en) | 2018-08-10 | 2018-08-10 | Recombinant nucleic acid construct |
EP18194023 | 2018-09-12 | ||
EP18248243 | 2018-12-28 | ||
PCT/EP2019/071173 WO2020030672A1 (en) | 2018-08-10 | 2019-08-07 | Recombinant nucleic acid construct |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021001547A true MX2021001547A (es) | 2021-06-23 |
Family
ID=67544260
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021001547A MX2021001547A (es) | 2018-08-10 | 2019-08-07 | Constructo de acido nucleico recombinante. |
Country Status (17)
Country | Link |
---|---|
US (1) | US20210261980A1 (es) |
EP (1) | EP3833786B1 (es) |
JP (1) | JP2021533821A (es) |
KR (1) | KR20210044240A (es) |
CN (1) | CN112567053A (es) |
AU (1) | AU2019319035A1 (es) |
BR (1) | BR112021002333A2 (es) |
CA (1) | CA3108670A1 (es) |
DK (1) | DK3833786T3 (es) |
ES (1) | ES2970185T3 (es) |
FI (1) | FI3833786T3 (es) |
IL (1) | IL280157A (es) |
MX (1) | MX2021001547A (es) |
PL (1) | PL3833786T3 (es) |
SG (1) | SG11202100455WA (es) |
WO (1) | WO2020030672A1 (es) |
ZA (1) | ZA202100242B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3865122A1 (en) * | 2020-02-11 | 2021-08-18 | Pantherna Therapeutics GmbH | Lipid composition and use thereof for delivery of a therapeutically active agent to endothelium |
WO2022106072A1 (en) | 2020-11-18 | 2022-05-27 | Aplicacion Y Suministros Textiles, S.A.U. | Textile stone washing process |
WO2022110010A1 (zh) * | 2020-11-27 | 2022-06-02 | 苏州吉玛基因股份有限公司 | 免疫激活剂、抗原和抗体在制备预防、治疗肿瘤产品中的应用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000006759A2 (en) * | 1998-07-27 | 2000-02-10 | Valentis, Inc. | Anti-angiogenesis plasmids and delivery systems, and methods of making and using the same |
GB9905498D0 (en) * | 1999-03-11 | 1999-05-05 | Glaxo Group Ltd | Expression |
US7098192B2 (en) * | 1999-04-08 | 2006-08-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of STAT3 expression |
US8039261B2 (en) * | 2000-11-17 | 2011-10-18 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
KR20120046163A (ko) * | 2009-06-15 | 2012-05-09 | 바이오카인 테라퓨틱스 리미티드 | 자가면역, 염증 및 암의 과정을 저해할 수 있는 신규한 케모카인 결합 폴리펩타이드류 |
CN102712935B (zh) | 2009-11-04 | 2017-04-26 | 不列颠哥伦比亚大学 | 含有核酸的脂质粒子及相关的方法 |
EA201301173A1 (ru) * | 2011-04-15 | 2015-08-31 | Дженелюкс Корпорейшн | Клональные штаммы аттенуированных вакцинирующих вирусов и способы их использования |
DE202015009974U1 (de) * | 2014-12-12 | 2022-02-17 | Curevac Ag | Artifizielle Nukleinsäuremoleküle für eine verbesserte Proteinexpression |
WO2017100551A1 (en) | 2015-12-09 | 2017-06-15 | Alexion Pharmaceuticals, Inc. | HETEROLOGOUS UTR SEQUENCES FOR ENHANCED mRNA EXPRESSION |
WO2017201332A1 (en) * | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Polynucleotides encoding acyl-coa dehydrogenase, very long-chain for the treatment of very long-chain acyl-coa dehydrogenase deficiency |
US11464847B2 (en) * | 2016-12-23 | 2022-10-11 | Curevac Ag | Lassa virus vaccine |
-
2019
- 2019-08-07 CN CN201980053544.5A patent/CN112567053A/zh active Pending
- 2019-08-07 PL PL19749727.4T patent/PL3833786T3/pl unknown
- 2019-08-07 ES ES19749727T patent/ES2970185T3/es active Active
- 2019-08-07 DK DK19749727.4T patent/DK3833786T3/da active
- 2019-08-07 SG SG11202100455WA patent/SG11202100455WA/en unknown
- 2019-08-07 CA CA3108670A patent/CA3108670A1/en active Pending
- 2019-08-07 JP JP2021531184A patent/JP2021533821A/ja active Pending
- 2019-08-07 KR KR1020217006630A patent/KR20210044240A/ko not_active Application Discontinuation
- 2019-08-07 WO PCT/EP2019/071173 patent/WO2020030672A1/en unknown
- 2019-08-07 BR BR112021002333-0A patent/BR112021002333A2/pt unknown
- 2019-08-07 MX MX2021001547A patent/MX2021001547A/es unknown
- 2019-08-07 AU AU2019319035A patent/AU2019319035A1/en active Pending
- 2019-08-07 EP EP19749727.4A patent/EP3833786B1/en active Active
- 2019-08-07 FI FIEP19749727.4T patent/FI3833786T3/fi active
-
2021
- 2021-01-13 IL IL280157A patent/IL280157A/en unknown
- 2021-01-13 ZA ZA2021/00242A patent/ZA202100242B/en unknown
- 2021-02-10 US US17/173,109 patent/US20210261980A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3833786B1 (en) | 2023-12-27 |
JP2021533821A (ja) | 2021-12-09 |
WO2020030672A1 (en) | 2020-02-13 |
BR112021002333A2 (pt) | 2021-05-04 |
CN112567053A (zh) | 2021-03-26 |
FI3833786T3 (fi) | 2024-03-15 |
SG11202100455WA (en) | 2021-02-25 |
CA3108670A1 (en) | 2020-02-13 |
ES2970185T3 (es) | 2024-05-27 |
AU2019319035A1 (en) | 2021-02-04 |
US20210261980A1 (en) | 2021-08-26 |
IL280157A (en) | 2021-03-01 |
KR20210044240A (ko) | 2021-04-22 |
ZA202100242B (en) | 2022-05-25 |
EP3833786A1 (en) | 2021-06-16 |
DK3833786T3 (da) | 2024-03-04 |
PL3833786T3 (pl) | 2024-05-06 |
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