MX2020012412A - Sistema de cultivo celular en biorreactor. - Google Patents

Sistema de cultivo celular en biorreactor.

Info

Publication number
MX2020012412A
MX2020012412A MX2020012412A MX2020012412A MX2020012412A MX 2020012412 A MX2020012412 A MX 2020012412A MX 2020012412 A MX2020012412 A MX 2020012412A MX 2020012412 A MX2020012412 A MX 2020012412A MX 2020012412 A MX2020012412 A MX 2020012412A
Authority
MX
Mexico
Prior art keywords
bioreactor
cell culture
compartments
extra
micro
Prior art date
Application number
MX2020012412A
Other languages
English (en)
Inventor
Maxime Feyeux
Kevin Alessandri
Pierre Nassoy
Original Assignee
Univ Bordeaux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bordeaux filed Critical Univ Bordeaux
Publication of MX2020012412A publication Critical patent/MX2020012412A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/10—Bioreactors or fermenters specially adapted for specific uses adapted for the cultivation of avian eggs or in avian eggs, e.g. for vaccine production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/20—Material Coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/04—Preserving or maintaining viable microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Clinical Laboratory Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La invención se refiere a un sistema de cultivo celular en biorreactor que comprende una cámara cerrada que contiene una pluralidad de microcompartimentos celulares, en donde los microcompartimentos comprenden cada uno una capa externa de hidrogel que proporciona una cavidad que contiene un conjunto de células autoorganizadas y una matriz extracelular o un sustituto de matriz extracelular. La invención también trata sobre el uso de dichos biorreactores para la producción de células y/u organoides, y/o moléculas y/o ensamblajes moleculares complejos.
MX2020012412A 2018-05-21 2019-05-20 Sistema de cultivo celular en biorreactor. MX2020012412A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1854207A FR3081168B1 (fr) 2018-05-21 2018-05-21 Systeme de culture cellulaire en bioreacteur
PCT/FR2019/051144 WO2019224467A1 (fr) 2018-05-21 2019-05-20 Système de culture cellulaire en bioréacteur

Publications (1)

Publication Number Publication Date
MX2020012412A true MX2020012412A (es) 2021-02-09

Family

ID=64049308

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012412A MX2020012412A (es) 2018-05-21 2019-05-20 Sistema de cultivo celular en biorreactor.

Country Status (14)

Country Link
US (1) US20210123013A1 (es)
EP (1) EP3797150A1 (es)
JP (1) JP2021524253A (es)
KR (1) KR20210011975A (es)
CN (1) CN112424333A (es)
AU (1) AU2019273006A1 (es)
BR (1) BR112020023707A2 (es)
CA (1) CA3101003A1 (es)
CL (1) CL2020003003A1 (es)
FR (1) FR3081168B1 (es)
IL (1) IL278775A (es)
MX (1) MX2020012412A (es)
SG (1) SG11202011501XA (es)
WO (1) WO2019224467A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114214267B (zh) * 2021-12-06 2024-04-09 大连大学 一种类器官基质胶微球及其制备方法和应用
CN114672455A (zh) * 2022-03-25 2022-06-28 中山大学 一种利用多能干细胞诱导骨髓基质细胞的方法
WO2023235884A1 (en) 2022-06-03 2023-12-07 Flagship Pioneering Innovations Vi, Llc Compositions and methods

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005010162A2 (en) * 2003-07-17 2005-02-03 Global Cell Solutions, Llc. Automated cell culture system and process
DE10349484A1 (de) * 2003-10-21 2005-05-25 Universität Leipzig Verfahren und Bioreaktor zum Kultivieren und Stimulieren von dreidimensionalen, vitalen und mechanisch widerstandsfähigen Zelltransplantaten
JP2006136212A (ja) * 2004-11-10 2006-06-01 Olympus Corp 細胞培養用担体
CN1288235C (zh) * 2004-11-25 2006-12-06 西安交通大学 一种旋转灌注式生物反应器系统
JP2009247334A (ja) * 2008-04-11 2009-10-29 Toray Ind Inc 細胞培養担体
EP3441458B9 (en) * 2009-02-03 2023-08-23 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells
EP2408904B1 (en) 2009-03-20 2017-10-18 Mesoblast, Inc. Production of reprogrammed pluripotent cells
SG10201914092XA (en) * 2011-06-06 2020-03-30 ReGenesys BVBA Expansion of stem cells in hollow fiber bioreactors
CN103146572B (zh) * 2011-12-07 2016-01-06 清华大学 一种实现细胞集落均质性生长的装置和方法
US9512393B2 (en) * 2012-09-06 2016-12-06 Pluristem Ltd. Devices and methods for culture of cells
WO2016103002A1 (en) * 2014-12-22 2016-06-30 Ecole Polytechnique Federale De Lausanne (Epfl) Devices for high-throughput aggregation and manipulation of mammalian cells
CN107427537A (zh) * 2015-03-03 2017-12-01 哈佛学院院长及董事 产生功能性人体组织的方法
EP3296018A1 (en) * 2016-09-19 2018-03-21 Ecole Polytechnique Fédérale de Lausanne (EPFL) Organoid arrays

Also Published As

Publication number Publication date
BR112020023707A2 (pt) 2021-02-09
IL278775A (en) 2021-01-31
WO2019224467A1 (fr) 2019-11-28
US20210123013A1 (en) 2021-04-29
AU2019273006A1 (en) 2020-12-03
FR3081168B1 (fr) 2022-03-11
JP2021524253A (ja) 2021-09-13
EP3797150A1 (fr) 2021-03-31
CN112424333A (zh) 2021-02-26
CA3101003A1 (fr) 2019-11-28
KR20210011975A (ko) 2021-02-02
CL2020003003A1 (es) 2021-04-16
SG11202011501XA (en) 2020-12-30
FR3081168A1 (fr) 2019-11-22

Similar Documents

Publication Publication Date Title
MX2020012412A (es) Sistema de cultivo celular en biorreactor.
EP4148121A3 (en) Cell-controlled perfusion in continuous culture
EP2268809A4 (en) NUCLEAR REPROGRAMMING PROCESS
MX2013014937A (es) Cultivo de celulas de mamifero.
WO2008154014A3 (en) A method for culturing mammalian cells to improve recombinant protein production
NO20064379L (no) Anvendelse av et serumfritt cellekulturmedium for produsjonen av IL-18BP i pattedyrceller
SG10201809452RA (en) Cell culture compositions with antioxidants and methods for polypeptide production
EP2604679A4 (en) CELL CULTURE PROCESSING SYSTEM AND METHOD FOR CONNECTING MODULES FOR A CELL CULTURE PROCESSING SYSTEM
MX348269B (es) Metodo para producir lamina celular epitelial de pigmento retinal.
MX2022004760A (es) Sistemas y métodos para el cultivo de células.
BR112016028512A8 (pt) método de cultivo de uma célula de mamífero e método de produção de uma proteína recombinante
WO2019022393A3 (ko) 나노다공성 투과막이 부착된 3차원 세포배양용 마이크로 칩 및 그의 제조방법
MX343113B (es) Medios de cultivo de celulas granulados en seco.
MX2020009648A (es) Muestreador de lecho fijo y metodos relacionados.
WO2019121961A3 (en) Methods for modulating protein mannosylation profiles using maduramycin, narasin, or salinomycin
EP3495467A4 (en) METHOD AND DEVICE FOR PRODUCING A CONTAINER, CELL CULTURE VESSEL, METHOD FOR CULTIVATING CELLS, METHOD FOR PRODUCING A CELL CULTURE VESSEL AND DEVICE FOR PRODUCING A CELL CULTURE VESSEL
EP3770248A4 (en) CELL CULTURE METHOD, CELL SUPPORT COMPOSITE PRODUCTION METHOD, CULTURED CELLS AND CELL SUPPORT COMPOSITE
MX2021001981A (es) Metodos para preparar un poloxamero para usar en medio de cultivo celular.
EP3569688A4 (en) CELL CULTURE SUBSTRATE, CULTURE CONTAINER, PROCESS FOR PRODUCING A CELL CULTURE CONTAINER, PROCESS FOR OBTAINING CELLS AND PROCESS FOR CELL CULTURE
EP4235175A3 (en) Methods for culturing human keratinocytes
EP3984596A4 (en) POPULATION OF CELLS COMPRISING MESENCHYMATOUS CELLS, PHARMACEUTICAL COMPOSITION COMPRISING THEM AND METHOD FOR PRODUCTION THEREOF
Cai et al. Differential Homeostasis of Sessile and Pendant Epithelium Reconstituted in a 3D‐Printed “GeminiChip”
CA2796599A1 (en) Method for producing induced pluripotent stem cells
EP3693452A4 (en) CELL CULTURE CONTAINERS, METHOD FOR CELL RECOVERY, AND METHOD FOR CULTIVATION OF CELLS
BRPI0418820A (pt) reator de exposição de fase de gás lìquido para cultivo de célula