MX2020012090A - Composicion farmaceutica del agonista del receptor de kor. - Google Patents

Composicion farmaceutica del agonista del receptor de kor.

Info

Publication number
MX2020012090A
MX2020012090A MX2020012090A MX2020012090A MX2020012090A MX 2020012090 A MX2020012090 A MX 2020012090A MX 2020012090 A MX2020012090 A MX 2020012090A MX 2020012090 A MX2020012090 A MX 2020012090A MX 2020012090 A MX2020012090 A MX 2020012090A
Authority
MX
Mexico
Prior art keywords
pharmaceutical composition
receptor agonist
kor receptor
kor
phenylalanyl
Prior art date
Application number
MX2020012090A
Other languages
English (en)
Inventor
Yi Fan
Yin Zhou
Weikang Tao
Xinyong Tong
Aifeng Zou
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2020012090A publication Critical patent/MX2020012090A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

En la presente invención se describe una composición farmacéutica de un agonista del receptor KOR, que comprende 4-amino-N- [N2- [N- [N- [N - ((R) -2-fenilpropil) glicil] -D- ácido fenilalanil] -D-leucil] -D-lisil] piperidin-4-carboxílico o sales disponibles del mismo, y una solución buffer de acetato.
MX2020012090A 2018-05-16 2019-05-15 Composicion farmaceutica del agonista del receptor de kor. MX2020012090A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810469196 2018-05-16
PCT/CN2019/086984 WO2019219019A1 (zh) 2018-05-16 2019-05-15 一种kor受体激动剂药物组合物

Publications (1)

Publication Number Publication Date
MX2020012090A true MX2020012090A (es) 2021-04-13

Family

ID=68539511

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020012090A MX2020012090A (es) 2018-05-16 2019-05-15 Composicion farmaceutica del agonista del receptor de kor.

Country Status (14)

Country Link
US (1) US20210205404A1 (es)
EP (1) EP3795166A4 (es)
JP (1) JP2021523924A (es)
KR (1) KR20210010490A (es)
CN (1) CN111148526B (es)
AU (1) AU2019271812A1 (es)
BR (1) BR112020023038A2 (es)
CA (1) CA3095966A1 (es)
MX (1) MX2020012090A (es)
RU (1) RU2768482C1 (es)
TW (1) TW202015716A (es)
UA (1) UA126835C2 (es)
WO (1) WO2019219019A1 (es)
ZA (1) ZA202006157B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11492374B2 (en) 2020-06-25 2022-11-08 Humanwell Pharmaceutical US Peptides for treatment of medical disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965701A (en) 1997-12-23 1999-10-12 Ferring Bv Kappa receptor opioid peptides
EP1984009B1 (en) * 2006-01-18 2012-10-24 Qps, Llc Pharmaceutical compositions with enhanced stability
WO2007139826A2 (en) 2006-05-26 2007-12-06 Cara Therapeutics, Inc. Method for elevating prolactin in mammals
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
CN105126071A (zh) * 2011-06-14 2015-12-09 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
US20150150935A1 (en) 2012-06-05 2015-06-04 Cara Therapeutics, Inc. Peripheral kappa receptor agonists for reducing pain and inflammation
US20150272927A1 (en) 2012-12-03 2015-10-01 University Of Washington Through Its Center For Commercialization Methods and compositions for treating vasomotor symptoms
WO2014184356A1 (en) 2013-05-17 2014-11-20 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Perhydroquinoxaline derivatives useful as analgesics
CN103405753B (zh) * 2013-08-13 2016-05-11 上海仁会生物制药股份有限公司 稳定的促胰岛素分泌肽水针药物组合物
WO2015065867A2 (en) 2013-10-28 2015-05-07 Cara Therapeutics, Inc. Peripheral kappa opioid receptor agonists for preventing, inhibiting or treating nausea and vomiting
HRP20221395T1 (hr) * 2016-04-14 2023-01-06 Pvp Labs Pte. Ltd. Formula lijeka za uporabu u učinkovitoj kontroli akutne i/ili kronične boli
CA3025710A1 (en) * 2016-06-07 2017-12-14 Jiangsu Hengrui Medicine Co., Ltd. Phenyl propanamide derivative, and manufacturing method and pharmaceutical application thereof
CN108883185B (zh) * 2016-12-06 2021-10-08 江苏恒瑞医药股份有限公司 一种κ阿片受体激动剂在制备治疗法尼醇X受体激动剂引起的瘙痒的药物中的用途

Also Published As

Publication number Publication date
EP3795166A4 (en) 2021-12-22
EP3795166A1 (en) 2021-03-24
CN111148526A (zh) 2020-05-12
AU2019271812A1 (en) 2021-01-07
KR20210010490A (ko) 2021-01-27
US20210205404A1 (en) 2021-07-08
UA126835C2 (uk) 2023-02-08
ZA202006157B (en) 2022-08-31
CN111148526B (zh) 2023-03-10
JP2021523924A (ja) 2021-09-09
BR112020023038A2 (pt) 2021-02-02
WO2019219019A1 (zh) 2019-11-21
CA3095966A1 (en) 2019-11-21
RU2768482C1 (ru) 2022-03-24
TW202015716A (zh) 2020-05-01

Similar Documents

Publication Publication Date Title
PH12020551066A1 (en) Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant
PH12016501310A1 (en) Pharmaceutical compositions comprising azd9291
JP2016222689A5 (ja) 合成ペプチド及び乾燥粉末薬剤輸送システム
WO2019215063A8 (en) Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
EA201992116A1 (ru) Фармацевтические составы флороглюцинола и триметилфлороглюцинола
CY1126067T1 (el) Συντηγμενες πυρρολινες που δρουν σαν ειδικοι για ουβικιτινη αναστολεις πρωτεασης 30 (usp30)
MX2022000827A (es) Composiciones solidas que comprenden un agonista del peptido similar al glucagon (glp-1), un inhibidor del transportador de sodio-glucosa 2 (sglt2) y una sal del acido n-(8-(2-hidroxibenzoil )amino)caprilico.
MX2021006969A (es) Ligante peptidico.
MX2022004718A (es) Omposiciones sólidas que comprenden un inhibidor de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) y una sal de ácido n-(8-(2-hidroxibenzoil)amino)caprílico.
TW201613557A (en) Stable aqueous recombinant protein formulations
MA50047A (fr) Administration orale d'analogues peptidiques de glp-1
CR20210435A (es) Formulación de anticuerpos terapéuticos
MX2020012090A (es) Composicion farmaceutica del agonista del receptor de kor.
MX2019003458A (es) Cristal no solvatado, metodo de preparacion y aplicacion del mismo.
PH12021550687A1 (en) Pharmaceutical composition for oral administration comprising aminopyrimidine derivative or its salt
EA202192322A1 (ru) Фармацевтические составы
MX2022000889A (es) Composiciones solidas que comprenden un derivado de egf(a) y una sal de acido n-(8-(2-hidroxibenzoil)amino)caprilico.
EA202190077A1 (ru) Ингибиторы гистондеацетилазы
CO2020013552A2 (es) Formulación de anticuerpos
MX2021015426A (es) Formulaciones estables de proteinas recombinantes.
WO2019151964A3 (en) Orally disintegrating formulations of saxagliptin
EA201891617A3 (ru) Комбинации, содержащие положительные аллостерические модуляторы или ортостерические агонисты метаботропного глутаматергического рецептора 2 подтипа, и их применение
MA52148A (fr) Peptides chimères pour administration d'antisens
MX2022003917A (es) Formulacion para suspension pediatrica.
MA55568A (fr) Compositions pharmaceutiques orodispersibles d'apixaban