MX2020007996A - Metodo para el aislamiento de citisina. - Google Patents
Metodo para el aislamiento de citisina.Info
- Publication number
- MX2020007996A MX2020007996A MX2020007996A MX2020007996A MX2020007996A MX 2020007996 A MX2020007996 A MX 2020007996A MX 2020007996 A MX2020007996 A MX 2020007996A MX 2020007996 A MX2020007996 A MX 2020007996A MX 2020007996 A MX2020007996 A MX 2020007996A
- Authority
- MX
- Mexico
- Prior art keywords
- alcohol
- concentrate
- chloroform
- extracted
- methylene chloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La invención se refiere a un método para el aislamiento de citisina a partir de material vegetal. El método de conformidad con la invención consiste en la extracción de la materia prima vegetal mediante un alcohol de bajo peso molecular, acidificado con un ácido mineral a un pH dentro de un intervalo de 1.5-3.5. Los extractos combinados en fase acuosa-alcohol se concentran mediante destilación al vacío hasta que se elimina el alcohol y, después de la filtración, se extraen con cloroformo, cloruro de metileno, acetato de butilo o butanol normal en una proporción de 1:1. El concentrado acuoso acidificado purificado a partir de sustancias fibrosas se alcaliniza a un pH de 9-12 con un hidróxido alcalino o hidróxido o de amonio, y el concentrado acuoso alcalino resultante se extrae al menos dos veces con cloroformo, cloruro de metileno, acetato de butilo o butano' normal en una proporción de concentrado: extractante de entre 1:5 y 1:10. Los extractos orgánicos combinados se evaporan hasta secar y a continuación se agrega acetona o acetato de etilo para obtener una suspensión que se deja cristalizar completamente a 5-10° C para posteriormente filtrar y secar. El producto aislado tiene una alta pureza y rendimiento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG11267118 | 2018-01-29 | ||
| PCT/BG2018/000044 WO2019144204A1 (en) | 2018-01-29 | 2018-11-19 | Method for isolation of cytisine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020007996A true MX2020007996A (es) | 2020-09-09 |
Family
ID=64606691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020007996A MX2020007996A (es) | 2018-01-29 | 2018-11-19 | Metodo para el aislamiento de citisina. |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US11505552B2 (es) |
| EP (1) | EP3746102A1 (es) |
| JP (1) | JP7083920B2 (es) |
| KR (1) | KR20200135316A (es) |
| CN (1) | CN111698997A (es) |
| AU (1) | AU2018403991B2 (es) |
| BG (1) | BG67483B1 (es) |
| CA (1) | CA3089516C (es) |
| MX (1) | MX2020007996A (es) |
| WO (1) | WO2019144204A1 (es) |
| ZA (1) | ZA202005380B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111698997A (zh) * | 2018-01-29 | 2020-09-22 | 索非药剂有限公司 | 金雀花碱的分离方法 |
| CN117916589A (zh) * | 2021-09-08 | 2024-04-19 | 阿奇维生命科学公司 | 评估野靛碱纯度的分析方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101624393B (zh) * | 2009-08-04 | 2011-08-24 | 王答祺 | 一种从披针叶黄华种籽中提取金雀花碱和黄华碱的方法 |
| CN101891740A (zh) | 2010-07-30 | 2010-11-24 | 王小银 | 从披针叶黄华草地上部分中提取金雀花碱的方法 |
| CN107266448A (zh) | 2017-07-25 | 2017-10-20 | 王答祺 | 制备金雀花碱的新工艺 |
| CN111698997A (zh) * | 2018-01-29 | 2020-09-22 | 索非药剂有限公司 | 金雀花碱的分离方法 |
-
2018
- 2018-11-19 CN CN201880087916.1A patent/CN111698997A/zh active Pending
- 2018-11-19 KR KR1020207025056A patent/KR20200135316A/ko not_active Application Discontinuation
- 2018-11-19 CA CA3089516A patent/CA3089516C/en active Active
- 2018-11-19 MX MX2020007996A patent/MX2020007996A/es unknown
- 2018-11-19 JP JP2020562799A patent/JP7083920B2/ja active Active
- 2018-11-19 AU AU2018403991A patent/AU2018403991B2/en active Active
- 2018-11-19 BG BG112905A patent/BG67483B1/bg unknown
- 2018-11-19 EP EP18814767.2A patent/EP3746102A1/en active Pending
- 2018-11-19 WO PCT/BG2018/000044 patent/WO2019144204A1/en unknown
- 2018-11-19 US US16/965,790 patent/US11505552B2/en active Active
-
2020
- 2020-08-28 ZA ZA2020/05380A patent/ZA202005380B/en unknown
-
2021
- 2021-06-10 US US17/344,090 patent/US11384080B2/en active Active
-
2022
- 2022-10-20 US US17/969,859 patent/US20230047648A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BG67483B1 (bg) | 2022-12-15 |
| JP7083920B2 (ja) | 2022-06-13 |
| WO2019144204A1 (en) | 2019-08-01 |
| US20200361938A1 (en) | 2020-11-19 |
| ZA202005380B (en) | 2021-09-29 |
| EP3746102A1 (en) | 2020-12-09 |
| AU2018403991B2 (en) | 2022-12-01 |
| US20230047648A1 (en) | 2023-02-16 |
| US20210300929A1 (en) | 2021-09-30 |
| CA3089516A1 (en) | 2019-08-01 |
| AU2018403991A1 (en) | 2020-08-13 |
| US11505552B2 (en) | 2022-11-22 |
| NZ766569A (en) | 2024-02-23 |
| JP2021512169A (ja) | 2021-05-13 |
| CN111698997A (zh) | 2020-09-22 |
| BG112905A (bg) | 2019-08-15 |
| CA3089516C (en) | 2023-10-31 |
| US11384080B2 (en) | 2022-07-12 |
| KR20200135316A (ko) | 2020-12-02 |
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