MX2020006068A - Derivados halogenados de morfinanos y sus usos. - Google Patents

Derivados halogenados de morfinanos y sus usos.

Info

Publication number
MX2020006068A
MX2020006068A MX2020006068A MX2020006068A MX2020006068A MX 2020006068 A MX2020006068 A MX 2020006068A MX 2020006068 A MX2020006068 A MX 2020006068A MX 2020006068 A MX2020006068 A MX 2020006068A MX 2020006068 A MX2020006068 A MX 2020006068A
Authority
MX
Mexico
Prior art keywords
morphinans
halogenated derivatives
compositions
improved
methods
Prior art date
Application number
MX2020006068A
Other languages
English (en)
Inventor
Raymond A Chavez
Stephen Collins
Original Assignee
Xalud Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xalud Therapeutics Inc filed Critical Xalud Therapeutics Inc
Publication of MX2020006068A publication Critical patent/MX2020006068A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invencion abarca las composiciones de morfinanos mejoradas y métodos de uso de las composiciones mejoradas para modular el dolor neuropatico, la activacion glial inducida por opioides, o una combinacion de los mismos mas alla de lo que se conoce en la técnica actualmente; los metodos abarcan administrar el compuesto de Formula I a un sujeto.
MX2020006068A 2017-12-12 2018-12-12 Derivados halogenados de morfinanos y sus usos. MX2020006068A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762597815P 2017-12-12 2017-12-12
PCT/US2018/065185 WO2019118583A1 (en) 2017-12-12 2018-12-12 Halogenated derivatives of morphinans and uses thereof

Publications (1)

Publication Number Publication Date
MX2020006068A true MX2020006068A (es) 2020-08-24

Family

ID=66820629

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006068A MX2020006068A (es) 2017-12-12 2018-12-12 Derivados halogenados de morfinanos y sus usos.

Country Status (11)

Country Link
US (2) US11505556B2 (es)
EP (1) EP3723749A4 (es)
JP (1) JP7307067B2 (es)
KR (1) KR20200097309A (es)
CN (1) CN111698987B (es)
AU (1) AU2018383773A1 (es)
BR (1) BR112020010901A2 (es)
CA (1) CA3085321C (es)
IL (1) IL274610B2 (es)
MX (1) MX2020006068A (es)
WO (1) WO2019118583A1 (es)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
US4556712A (en) 1981-05-20 1985-12-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
US4410700A (en) 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4368326A (en) 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4521601A (en) 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4613668A (en) 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4775759A (en) * 1984-11-27 1988-10-04 The United States Of America As Represented By The Department Of Health And Human Services Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT)
US5668285A (en) 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US5008449A (en) 1989-03-03 1991-04-16 The United States Of America As Represented By The Department Of Health And Human Services Method of synthesis of hydroxy-substituted-4-alkoxyphenylacetic acids
PT95069B (pt) 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
DE60217835D1 (en) * 2001-02-28 2007-03-15 John H Griffin Plasmaglucosylceramiddefizienz als risikofaktor für thrombose und modulator von anticoagulant protein c
WO2008137672A1 (en) * 2007-05-04 2008-11-13 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
WO2009059048A2 (en) 2007-10-30 2009-05-07 The Regents Of The University Of Colorado (+)-opioids and methods of use
US20100239523A1 (en) 2007-10-30 2010-09-23 The Regents Of The University Of Colorado Tlr modulators and methods for using the same
ES2569655T3 (es) * 2007-12-17 2016-05-12 Mallinckrodt Llc Procedimientos para la producción de compuestos de (+)-'nal' morfinano
EP2328900B1 (en) * 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. PROCESS FOR MAKING MORPHINAN-6 alpha-OLS
CA2676881C (en) * 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Also Published As

Publication number Publication date
CA3085321A1 (en) 2019-06-20
IL274610B2 (en) 2023-12-01
JP2021506768A (ja) 2021-02-22
JP7307067B2 (ja) 2023-07-11
US20230203053A1 (en) 2023-06-29
EP3723749A1 (en) 2020-10-21
IL274610B1 (en) 2023-08-01
IL274610A (en) 2020-06-30
CA3085321C (en) 2023-10-31
EP3723749A4 (en) 2022-06-08
WO2019118583A1 (en) 2019-06-20
US11505556B2 (en) 2022-11-22
CN111698987A (zh) 2020-09-22
AU2018383773A1 (en) 2020-06-11
BR112020010901A2 (pt) 2020-11-17
US20210087202A1 (en) 2021-03-25
CN111698987B (zh) 2024-08-13
KR20200097309A (ko) 2020-08-18

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MX2020006068A (es) Derivados halogenados de morfinanos y sus usos.