MX2020004946A - Inhibidores jak de pirrolopiridina sustituidos y metodos para producir y utilizar los mismos. - Google Patents

Inhibidores jak de pirrolopiridina sustituidos y metodos para producir y utilizar los mismos.

Info

Publication number
MX2020004946A
MX2020004946A MX2020004946A MX2020004946A MX2020004946A MX 2020004946 A MX2020004946 A MX 2020004946A MX 2020004946 A MX2020004946 A MX 2020004946A MX 2020004946 A MX2020004946 A MX 2020004946A MX 2020004946 A MX2020004946 A MX 2020004946A
Authority
MX
Mexico
Prior art keywords
methods
making
same
jak inhibitors
substituted pyrrolopyrimidine
Prior art date
Application number
MX2020004946A
Other languages
English (en)
Spanish (es)
Inventor
Eric Jon Jacobsen
Susan Landis Hockerman
James Robert Blinn
David Randolph Anderson
Original Assignee
Aclaris Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclaris Therapeutics Inc filed Critical Aclaris Therapeutics Inc
Publication of MX2020004946A publication Critical patent/MX2020004946A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Oncology (AREA)
  • Diabetes (AREA)
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  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
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  • Cardiology (AREA)
  • Endocrinology (AREA)
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  • Psychology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
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MX2020004946A 2017-11-03 2018-11-02 Inhibidores jak de pirrolopiridina sustituidos y metodos para producir y utilizar los mismos. MX2020004946A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762581428P 2017-11-03 2017-11-03
US201862670448P 2018-05-11 2018-05-11
PCT/US2018/059071 WO2019090158A1 (en) 2017-11-03 2018-11-02 Substituted pyrrolopyrimidine jak inhibitors and methods of making and using the same

Publications (1)

Publication Number Publication Date
MX2020004946A true MX2020004946A (es) 2020-09-25

Family

ID=66328264

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004946A MX2020004946A (es) 2017-11-03 2018-11-02 Inhibidores jak de pirrolopiridina sustituidos y metodos para producir y utilizar los mismos.

Country Status (12)

Country Link
US (4) US10981906B2 (https=)
EP (1) EP3710431A4 (https=)
JP (2) JP2021502400A (https=)
KR (1) KR102821964B1 (https=)
CN (2) CN119119039A (https=)
AU (2) AU2018360059B2 (https=)
BR (1) BR112020008850A2 (https=)
CA (1) CA3081751A1 (https=)
MX (1) MX2020004946A (https=)
PH (1) PH12020550499A1 (https=)
SG (1) SG11202002947TA (https=)
WO (1) WO2019090158A1 (https=)

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CN113498352A (zh) 2019-01-23 2021-10-12 施万生物制药研发Ip有限责任公司 作为jak抑制剂的咪唑并[1,5-a]吡啶、1,2,4-三唑并[4,3-a]吡啶和咪唑并[1,5-a]吡嗪
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WO2022067106A1 (en) * 2020-09-25 2022-03-31 Aclaris Therapeutics, Inc. Crystalline polymorph form a of a jak inhibitor and methods for its preparation
TW202302104A (zh) * 2021-02-18 2023-01-16 美商阿克拉里斯醫療股份有限公司 Jak 1/3抑制劑的局部配方及其用於治療異位性皮膚炎和其他皮膚狀況之用法
CN117279915A (zh) * 2021-02-18 2023-12-22 阿克拉瑞斯治疗股份有限公司 Jak1/3抑制剂的局部制剂及其用于特异性皮炎和其他皮肤病况的治疗的方法
WO2022199599A1 (zh) * 2021-03-23 2022-09-29 凯复(苏州)生物医药有限公司 丙烯酰基取代的化合物、包含其的药物组合物及其用途
CN118984868A (zh) 2021-12-31 2024-11-19 恩派瑞安神经科学公司 用于产生精神药物生物碱的遗传修饰的生物体
WO2023151069A1 (zh) * 2022-02-14 2023-08-17 湖南南新制药股份有限公司 吡咯并[2,3-d]六元杂芳环衍生物、其制备方法和药物用途
WO2023165562A1 (zh) * 2022-03-02 2023-09-07 南京明德新药研发有限公司 含氮杂环类化合物及其应用
US12564326B2 (en) 2022-10-25 2026-03-03 GE Precision Healthcare LLC Non-invasive bilirubin detection using induced photoreaction
WO2025038910A1 (en) * 2023-08-16 2025-02-20 Aclaris Therapeutics, Inc. Crystalline polymorph form a of a jak inhibitor and methods for its preparation

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