KR102821964B1 - 치환된 피롤로피리미딘 jak 억제제 및 이의 제조 및 사용 방법 - Google Patents

치환된 피롤로피리미딘 jak 억제제 및 이의 제조 및 사용 방법 Download PDF

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KR102821964B1
KR102821964B1 KR1020207015703A KR20207015703A KR102821964B1 KR 102821964 B1 KR102821964 B1 KR 102821964B1 KR 1020207015703 A KR1020207015703 A KR 1020207015703A KR 20207015703 A KR20207015703 A KR 20207015703A KR 102821964 B1 KR102821964 B1 KR 102821964B1
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KR20200083553A (ko
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데이비드 랜돌프 앤더슨
수잔 랜디스 호커맨
제임스 로버트 블린
에릭 존 제이콥슨
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어클라리스 쎄라퓨틱스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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KR1020207015703A 2017-11-03 2018-11-02 치환된 피롤로피리미딘 jak 억제제 및 이의 제조 및 사용 방법 Active KR102821964B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762581428P 2017-11-03 2017-11-03
US62/581,428 2017-11-03
US201862670448P 2018-05-11 2018-05-11
US62/670,448 2018-05-11
PCT/US2018/059071 WO2019090158A1 (en) 2017-11-03 2018-11-02 Substituted pyrrolopyrimidine jak inhibitors and methods of making and using the same

Publications (2)

Publication Number Publication Date
KR20200083553A KR20200083553A (ko) 2020-07-08
KR102821964B1 true KR102821964B1 (ko) 2025-06-19

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US (4) US10981906B2 (https=)
EP (1) EP3710431A4 (https=)
JP (2) JP2021502400A (https=)
KR (1) KR102821964B1 (https=)
CN (2) CN119119039A (https=)
AU (2) AU2018360059B2 (https=)
BR (1) BR112020008850A2 (https=)
CA (1) CA3081751A1 (https=)
MX (1) MX2020004946A (https=)
PH (1) PH12020550499A1 (https=)
SG (1) SG11202002947TA (https=)
WO (1) WO2019090158A1 (https=)

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AU2021350089A1 (en) * 2020-09-25 2023-04-13 Aclaris Therapeutics, Inc. Crystalline polymorph form a of a jak inhibitor and methods for its preparation
TW202302104A (zh) * 2021-02-18 2023-01-16 美商阿克拉里斯醫療股份有限公司 Jak 1/3抑制劑的局部配方及其用於治療異位性皮膚炎和其他皮膚狀況之用法
CN117279915A (zh) * 2021-02-18 2023-12-22 阿克拉瑞斯治疗股份有限公司 Jak1/3抑制剂的局部制剂及其用于特异性皮炎和其他皮肤病况的治疗的方法
WO2022199599A1 (zh) * 2021-03-23 2022-09-29 凯复(苏州)生物医药有限公司 丙烯酰基取代的化合物、包含其的药物组合物及其用途
EP4457336A4 (en) 2021-12-31 2026-01-14 Empyrean Neuroscience Inc ORGANISMS GENETICALLY MODIFIED TO PRODUCE PSYCHOTROPIC ALKALOIDS
WO2023151069A1 (zh) * 2022-02-14 2023-08-17 湖南南新制药股份有限公司 吡咯并[2,3-d]六元杂芳环衍生物、其制备方法和药物用途
WO2023165562A1 (zh) * 2022-03-02 2023-09-07 南京明德新药研发有限公司 含氮杂环类化合物及其应用
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