MX2020004345A - Nuevos derivados macrocíclicos, su proceso de preparación y las composiciones farmacéuticas que los contienen. - Google Patents

Nuevos derivados macrocíclicos, su proceso de preparación y las composiciones farmacéuticas que los contienen.

Info

Publication number
MX2020004345A
MX2020004345A MX2020004345A MX2020004345A MX2020004345A MX 2020004345 A MX2020004345 A MX 2020004345A MX 2020004345 A MX2020004345 A MX 2020004345A MX 2020004345 A MX2020004345 A MX 2020004345A MX 2020004345 A MX2020004345 A MX 2020004345A
Authority
MX
Mexico
Prior art keywords
same
pharmaceutical compositions
compositions containing
novel macrocyclic
macrocyclic derivatives
Prior art date
Application number
MX2020004345A
Other languages
English (en)
Inventor
Imre Fejes
Didier Durand
Tiran Arnaud Le
Jérôme-Benoît Starck
I-Jen Chen
Jean-Claude Ortuno
Miklós Nyerges
Melinda Ligeti
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MX2020004345A publication Critical patent/MX2020004345A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

El compuesto de la fórmula (I): en donde A1, A2, Ra, Rb, Rc, Rd, R3, R4, X, Y y G son tales como se han definido en la descripción, y su uso en la fabricación de medicamentos.
MX2020004345A 2017-10-25 2018-10-24 Nuevos derivados macrocíclicos, su proceso de preparación y las composiciones farmacéuticas que los contienen. MX2020004345A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1760078A FR3072679B1 (fr) 2017-10-25 2017-10-25 Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/EP2018/079113 WO2019081559A1 (fr) 2017-10-25 2018-10-24 Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
MX2020004345A true MX2020004345A (es) 2020-10-14

Family

ID=61599283

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020004345A MX2020004345A (es) 2017-10-25 2018-10-24 Nuevos derivados macrocíclicos, su proceso de preparación y las composiciones farmacéuticas que los contienen.

Country Status (26)

Country Link
US (1) US11833162B2 (es)
EP (1) EP3700911B1 (es)
JP (1) JP7253543B2 (es)
KR (1) KR102645096B1 (es)
CN (1) CN111511750B (es)
AR (1) AR113789A1 (es)
AU (1) AU2018355709B2 (es)
BR (1) BR112020007924A2 (es)
CA (1) CA3080116C (es)
CL (1) CL2020001073A1 (es)
CR (1) CR20200169A (es)
EA (1) EA202090978A1 (es)
EC (1) ECSP20023535A (es)
ES (1) ES2963996T3 (es)
FR (1) FR3072679B1 (es)
IL (1) IL274141A (es)
JO (1) JOP20200089A1 (es)
LT (1) LT3700911T (es)
MA (1) MA50450B1 (es)
MX (1) MX2020004345A (es)
NI (1) NI202000028A (es)
PE (1) PE20201498A1 (es)
PH (1) PH12020550448A1 (es)
SG (1) SG11202003550VA (es)
TW (1) TWI685498B (es)
WO (1) WO2019081559A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110256245A (zh) * 2019-06-06 2019-09-20 常州合全药业有限公司 一种4-氯-2-溴苯甲酸叔丁酯的合成方法
KR102589629B1 (ko) 2021-10-06 2023-10-13 한국생명공학연구원 파우시박터 아쿠아틸 유래 신규 화합물 및 이의 용도
WO2023225359A1 (en) 2022-05-20 2023-11-23 Novartis Ag Antibody-drug conjugates of antineoplastic compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2986002B1 (fr) * 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2014022752A1 (en) * 2012-08-03 2014-02-06 Amgen Inc. Macrocycles as pim inhibitors
FR3008979B1 (fr) * 2013-07-23 2015-07-24 Servier Lab Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008975A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子

Also Published As

Publication number Publication date
KR20200077541A (ko) 2020-06-30
PE20201498A1 (es) 2020-12-29
CN111511750B (zh) 2023-06-13
AU2018355709B2 (en) 2023-02-23
AR113789A1 (es) 2020-06-10
BR112020007924A2 (pt) 2020-10-20
US20200253993A1 (en) 2020-08-13
IL274141A (en) 2020-06-30
AU2018355709A1 (en) 2020-05-07
TWI685498B (zh) 2020-02-21
NI202000028A (es) 2020-10-06
ECSP20023535A (es) 2020-05-29
CL2020001073A1 (es) 2020-12-04
LT3700911T (lt) 2023-10-10
CA3080116C (fr) 2023-01-10
TW201922754A (zh) 2019-06-16
JP2021500370A (ja) 2021-01-07
EP3700911A1 (fr) 2020-09-02
FR3072679A1 (fr) 2019-04-26
RU2020116154A (ru) 2021-11-25
EA202090978A1 (ru) 2020-09-07
ES2963996T3 (es) 2024-04-03
CR20200169A (es) 2020-06-14
JOP20200089A1 (ar) 2020-05-03
MA50450A (fr) 2020-09-02
FR3072679B1 (fr) 2020-10-30
SG11202003550VA (en) 2020-05-28
JP7253543B2 (ja) 2023-04-06
RU2020116154A3 (es) 2022-03-11
CN111511750A (zh) 2020-08-07
CA3080116A1 (fr) 2019-05-02
WO2019081559A1 (fr) 2019-05-02
EP3700911B1 (fr) 2023-09-06
KR102645096B1 (ko) 2024-03-06
US11833162B2 (en) 2023-12-05
MA50450B1 (fr) 2023-10-31
PH12020550448A1 (en) 2021-04-26

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