JOP20200089A1 - مشتقات جديدة ضخمة الحلقات وعملية لتحضيرها والتركيبات الصيدلية التى تحتوي عليها - Google Patents
مشتقات جديدة ضخمة الحلقات وعملية لتحضيرها والتركيبات الصيدلية التى تحتوي عليهاInfo
- Publication number
- JOP20200089A1 JOP20200089A1 JOP/2020/0089A JOP20200089A JOP20200089A1 JO P20200089 A1 JOP20200089 A1 JO P20200089A1 JO P20200089 A JOP20200089 A JO P20200089A JO P20200089 A1 JOP20200089 A1 JO P20200089A1
- Authority
- JO
- Jordan
- Prior art keywords
- same
- pharmaceutical compositions
- compositions containing
- novel macrocyclic
- macrocyclic derivatives
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
مركب له الصيغة (I): حيث يتم تحديد A1، A2، Ra، Rb، Rc، Rd، R3، R4، X، Y وG كما هو موضح في الوصف، واستخدامها فى صناعة الأدوية.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1760078A FR3072679B1 (fr) | 2017-10-25 | 2017-10-25 | Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| PCT/EP2018/079113 WO2019081559A1 (fr) | 2017-10-25 | 2018-10-24 | Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JOP20200089A1 true JOP20200089A1 (ar) | 2020-05-03 |
Family
ID=61599283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2020/0089A JOP20200089A1 (ar) | 2017-10-25 | 2018-10-24 | مشتقات جديدة ضخمة الحلقات وعملية لتحضيرها والتركيبات الصيدلية التى تحتوي عليها |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11833162B2 (ar) |
| EP (1) | EP3700911B1 (ar) |
| JP (1) | JP7253543B2 (ar) |
| KR (1) | KR102645096B1 (ar) |
| CN (1) | CN111511750B (ar) |
| AR (1) | AR113789A1 (ar) |
| AU (1) | AU2018355709B2 (ar) |
| BR (1) | BR112020007924A2 (ar) |
| CA (1) | CA3080116C (ar) |
| CL (1) | CL2020001073A1 (ar) |
| CR (1) | CR20200169A (ar) |
| EA (1) | EA202090978A1 (ar) |
| EC (1) | ECSP20023535A (ar) |
| ES (1) | ES2963996T3 (ar) |
| FR (1) | FR3072679B1 (ar) |
| IL (1) | IL274141A (ar) |
| JO (1) | JOP20200089A1 (ar) |
| LT (1) | LT3700911T (ar) |
| MA (1) | MA50450B1 (ar) |
| MX (1) | MX2020004345A (ar) |
| NI (1) | NI202000028A (ar) |
| PE (1) | PE20201498A1 (ar) |
| PH (1) | PH12020550448A1 (ar) |
| SG (1) | SG11202003550VA (ar) |
| TW (1) | TWI685498B (ar) |
| WO (1) | WO2019081559A1 (ar) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110256245A (zh) * | 2019-06-06 | 2019-09-20 | 常州合全药业有限公司 | 一种4-氯-2-溴苯甲酸叔丁酯的合成方法 |
| KR102589629B1 (ko) | 2021-10-06 | 2023-10-13 | 한국생명공학연구원 | 파우시박터 아쿠아틸 유래 신규 화합물 및 이의 용도 |
| TW202408588A (zh) | 2022-05-20 | 2024-03-01 | 瑞士商諾華公司 | 抗體-藥物結合物抗腫瘤化合物及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2986002B1 (fr) * | 2012-01-24 | 2014-02-21 | Servier Lab | Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2014022752A1 (en) * | 2012-08-03 | 2014-02-06 | Amgen Inc. | Macrocycles as pim inhibitors |
| FR3008976A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| FR3008979B1 (fr) | 2013-07-23 | 2015-07-24 | Servier Lab | Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008975A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| CN108368161A (zh) * | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | 作为mcl-1调节剂的拟肽大环化合物 |
-
2017
- 2017-10-25 FR FR1760078A patent/FR3072679B1/fr active Active
-
2018
- 2018-10-24 KR KR1020207014452A patent/KR102645096B1/ko active IP Right Grant
- 2018-10-24 CA CA3080116A patent/CA3080116C/fr active Active
- 2018-10-24 LT LTEPPCT/EP2018/079113T patent/LT3700911T/lt unknown
- 2018-10-24 MA MA50450A patent/MA50450B1/fr unknown
- 2018-10-24 EP EP18796605.6A patent/EP3700911B1/fr active Active
- 2018-10-24 JO JOP/2020/0089A patent/JOP20200089A1/ar unknown
- 2018-10-24 WO PCT/EP2018/079113 patent/WO2019081559A1/fr unknown
- 2018-10-24 EA EA202090978A patent/EA202090978A1/ru unknown
- 2018-10-24 CR CR20200169A patent/CR20200169A/es unknown
- 2018-10-24 CN CN201880082991.9A patent/CN111511750B/zh active Active
- 2018-10-24 MX MX2020004345A patent/MX2020004345A/es unknown
- 2018-10-24 AR ARP180103095A patent/AR113789A1/es unknown
- 2018-10-24 ES ES18796605T patent/ES2963996T3/es active Active
- 2018-10-24 US US16/757,052 patent/US11833162B2/en active Active
- 2018-10-24 TW TW107137511A patent/TWI685498B/zh not_active IP Right Cessation
- 2018-10-24 SG SG11202003550VA patent/SG11202003550VA/en unknown
- 2018-10-24 BR BR112020007924-3A patent/BR112020007924A2/pt unknown
- 2018-10-24 PE PE2020000542A patent/PE20201498A1/es unknown
- 2018-10-24 AU AU2018355709A patent/AU2018355709B2/en active Active
- 2018-10-24 JP JP2020522921A patent/JP7253543B2/ja active Active
-
2020
- 2020-04-17 NI NI202000028A patent/NI202000028A/es unknown
- 2020-04-18 PH PH12020550448A patent/PH12020550448A1/en unknown
- 2020-04-21 CL CL2020001073A patent/CL2020001073A1/es unknown
- 2020-04-22 IL IL274141A patent/IL274141A/en unknown
- 2020-04-24 EC ECSENADI202023535A patent/ECSP20023535A/es unknown
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