CL2020001073A1 - Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen. - Google Patents
Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen.Info
- Publication number
- CL2020001073A1 CL2020001073A1 CL2020001073A CL2020001073A CL2020001073A1 CL 2020001073 A1 CL2020001073 A1 CL 2020001073A1 CL 2020001073 A CL2020001073 A CL 2020001073A CL 2020001073 A CL2020001073 A CL 2020001073A CL 2020001073 A1 CL2020001073 A1 CL 2020001073A1
- Authority
- CL
- Chile
- Prior art keywords
- contain
- pharmaceutical compositions
- preparation process
- macrocyclic derivatives
- new macrocyclic
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Compuesto de fórmula (I): en la que A1, A2, Ra, Rb, Rc, Rd, R3, R4, X, Y y G son tales como se han definido en la descripción, y su utilización en la fabricación de medicamentos
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1760078A FR3072679B1 (fr) | 2017-10-25 | 2017-10-25 | Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2020001073A1 true CL2020001073A1 (es) | 2020-12-04 |
Family
ID=61599283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2020001073A CL2020001073A1 (es) | 2017-10-25 | 2020-04-21 | Nuevos derivados macrocíclicos, su procedimiento de preparación y las composiciones farmacéuticas que los contienen. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11833162B2 (es) |
| EP (1) | EP3700911B1 (es) |
| JP (1) | JP7253543B2 (es) |
| KR (1) | KR102645096B1 (es) |
| CN (1) | CN111511750B (es) |
| AR (1) | AR113789A1 (es) |
| AU (1) | AU2018355709B2 (es) |
| BR (1) | BR112020007924A2 (es) |
| CA (1) | CA3080116C (es) |
| CL (1) | CL2020001073A1 (es) |
| CR (1) | CR20200169A (es) |
| EA (1) | EA202090978A1 (es) |
| EC (1) | ECSP20023535A (es) |
| ES (1) | ES2963996T3 (es) |
| FR (1) | FR3072679B1 (es) |
| IL (1) | IL274141A (es) |
| JO (1) | JOP20200089A1 (es) |
| LT (1) | LT3700911T (es) |
| MA (1) | MA50450B1 (es) |
| MX (1) | MX2020004345A (es) |
| NI (1) | NI202000028A (es) |
| PE (1) | PE20201498A1 (es) |
| PH (1) | PH12020550448A1 (es) |
| SG (1) | SG11202003550VA (es) |
| TW (1) | TWI685498B (es) |
| WO (1) | WO2019081559A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110256245A (zh) * | 2019-06-06 | 2019-09-20 | 常州合全药业有限公司 | 一种4-氯-2-溴苯甲酸叔丁酯的合成方法 |
| KR102589629B1 (ko) | 2021-10-06 | 2023-10-13 | 한국생명공학연구원 | 파우시박터 아쿠아틸 유래 신규 화합물 및 이의 용도 |
| TW202408588A (zh) | 2022-05-20 | 2024-03-01 | 瑞士商諾華公司 | 抗體-藥物結合物抗腫瘤化合物及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2986002B1 (fr) * | 2012-01-24 | 2014-02-21 | Servier Lab | Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2014022752A1 (en) * | 2012-08-03 | 2014-02-06 | Amgen Inc. | Macrocycles as pim inhibitors |
| FR3008975A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008979B1 (fr) * | 2013-07-23 | 2015-07-24 | Servier Lab | Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR3008976A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
| EP3347372A4 (en) | 2015-09-10 | 2019-09-04 | Aileron Therapeutics, Inc. | PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1 |
-
2017
- 2017-10-25 FR FR1760078A patent/FR3072679B1/fr active Active
-
2018
- 2018-10-24 CA CA3080116A patent/CA3080116C/fr active Active
- 2018-10-24 EA EA202090978A patent/EA202090978A1/ru unknown
- 2018-10-24 BR BR112020007924-3A patent/BR112020007924A2/pt unknown
- 2018-10-24 US US16/757,052 patent/US11833162B2/en active Active
- 2018-10-24 KR KR1020207014452A patent/KR102645096B1/ko active IP Right Grant
- 2018-10-24 WO PCT/EP2018/079113 patent/WO2019081559A1/fr unknown
- 2018-10-24 LT LTEPPCT/EP2018/079113T patent/LT3700911T/lt unknown
- 2018-10-24 TW TW107137511A patent/TWI685498B/zh not_active IP Right Cessation
- 2018-10-24 AU AU2018355709A patent/AU2018355709B2/en active Active
- 2018-10-24 CN CN201880082991.9A patent/CN111511750B/zh active Active
- 2018-10-24 ES ES18796605T patent/ES2963996T3/es active Active
- 2018-10-24 JO JOP/2020/0089A patent/JOP20200089A1/ar unknown
- 2018-10-24 EP EP18796605.6A patent/EP3700911B1/fr active Active
- 2018-10-24 MA MA50450A patent/MA50450B1/fr unknown
- 2018-10-24 MX MX2020004345A patent/MX2020004345A/es unknown
- 2018-10-24 AR ARP180103095A patent/AR113789A1/es unknown
- 2018-10-24 JP JP2020522921A patent/JP7253543B2/ja active Active
- 2018-10-24 CR CR20200169A patent/CR20200169A/es unknown
- 2018-10-24 SG SG11202003550VA patent/SG11202003550VA/en unknown
- 2018-10-24 PE PE2020000542A patent/PE20201498A1/es unknown
-
2020
- 2020-04-17 NI NI202000028A patent/NI202000028A/es unknown
- 2020-04-18 PH PH12020550448A patent/PH12020550448A1/en unknown
- 2020-04-21 CL CL2020001073A patent/CL2020001073A1/es unknown
- 2020-04-22 IL IL274141A patent/IL274141A/en unknown
- 2020-04-24 EC ECSENADI202023535A patent/ECSP20023535A/es unknown
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