MX2020001979A - Macrociclo que contiene aminopirazol y pirimidina y composicion farmaceutica y uso de la misma. - Google Patents

Macrociclo que contiene aminopirazol y pirimidina y composicion farmaceutica y uso de la misma.

Info

Publication number
MX2020001979A
MX2020001979A MX2020001979A MX2020001979A MX2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A MX 2020001979 A MX2020001979 A MX 2020001979A
Authority
MX
Mexico
Prior art keywords
pyrimidine
pharmaceutical composition
macrocycle containing
aminopyrazole
containing aminopyrazole
Prior art date
Application number
MX2020001979A
Other languages
English (en)
Inventor
Yang Ling
Zhao Na
Dai Liguang
Duan Xiaowei
Yang Yanqing
Sun Yinghui
Kong Fansheng
Liu Xijie
Li Hongjuan
Zhang Jiuqing
Zhu Yizhong
Liu Fei
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of MX2020001979A publication Critical patent/MX2020001979A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Abstract

La presente solicitud se refiere a un macrociclo que contiene aminopirazol y pirimidina, que está representado por la fórmula (I), a una composición farmacéutica del mismo y a su uso en la inhibición de la actividad de la quinasa del receptor de tropomiosina (Trk) y en el tratamiento de enfermedades en mamíferos que están mediadas por Trk (ver Fórmula).
MX2020001979A 2017-08-23 2018-08-23 Macrociclo que contiene aminopirazol y pirimidina y composicion farmaceutica y uso de la misma. MX2020001979A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710728132 2017-08-23
PCT/CN2018/101960 WO2019037761A1 (zh) 2017-08-23 2018-08-23 含有氨基吡唑并嘧啶的大环化合物及其药物组合物和用途

Publications (1)

Publication Number Publication Date
MX2020001979A true MX2020001979A (es) 2020-03-24

Family

ID=65439377

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020001979A MX2020001979A (es) 2017-08-23 2018-08-23 Macrociclo que contiene aminopirazol y pirimidina y composicion farmaceutica y uso de la misma.

Country Status (15)

Country Link
US (1) US11098060B2 (es)
EP (1) EP3674307B1 (es)
JP (1) JP7239563B2 (es)
KR (1) KR102619444B1 (es)
CN (2) CN113735881A (es)
AU (1) AU2018320021C1 (es)
BR (1) BR112020003783A2 (es)
CA (1) CA3071032A1 (es)
DK (1) DK3674307T3 (es)
ES (1) ES2951427T3 (es)
FI (1) FI3674307T3 (es)
MX (1) MX2020001979A (es)
PL (1) PL3674307T3 (es)
WO (1) WO2019037761A1 (es)
ZA (1) ZA202001442B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111343987A (zh) 2017-11-10 2020-06-26 安杰斯制药公司 作为trk激酶抑制剂之巨环化合物及其用途
JP7092405B2 (ja) * 2018-04-16 2022-06-28 深▲チェン▼市塔吉瑞生物医薬有限公司 キナーゼ活性を阻害するためのジ（ヘテロ）アリール大環状化合物
CA3117200A1 (en) 2018-10-22 2020-04-30 Esker Therapeutics, Inc. Tyk2 inhibitors and uses thereof
CN113727984B (zh) * 2019-05-21 2024-03-15 浙江海正药业股份有限公司 大环类衍生物、及其制备方法和用途
CN112110938B (zh) * 2019-06-21 2021-11-09 成都海博为药业有限公司 一种作为蛋白质激酶抑制剂的化合物及其制备方法和用途
CN111875620B (zh) * 2020-09-28 2020-12-11 上海美迪西生物医药股份有限公司 吡唑并嘧啶类大环衍生物及其应用
CN113475740B (zh) * 2021-07-10 2022-10-21 深圳市真味生物科技有限公司 一种手性合成尼古丁的制备方法
WO2023025141A1 (zh) * 2021-08-23 2023-03-02 正大天晴药业集团股份有限公司 含有氨基的大环化合物在治疗trk激酶介导的肿瘤中的用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2952692C (en) 2008-09-22 2020-04-28 Array Biopharma Inc. Substituted imidazo[1,2b]pyridazine compounds
TWI458729B (zh) * 2008-10-22 2014-11-01 Array Biopharma Inc 作為ＴＲＫ激酶抑制劑之經取代吡唑并〔１，５－ａ〕嘧啶化合物
CR20170098A (es) * 2010-05-20 2017-07-17 Array Biopharma Inc Compuestos macrociclicos como inhibidores de quinasa trk
PE20140378A1 (es) 2011-02-25 2014-03-28 Irm Llc Compuestos y composiciones como inhibidores de la trk
US10316044B2 (en) 2015-07-02 2019-06-11 Tp Therapeutics, Inc. Chiral diaryl macrocycles as modulators of protein kinases
WO2017035354A1 (en) 2015-08-26 2017-03-02 Blueprint Medicines Corporation Compounds and compositions useful for treating disorders related to ntrk
PL3533796T3 (pl) 2016-10-28 2022-01-17 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Związek aminopirazolopirymidynowy stosowany jako inhibitor receptora o aktywności kinazy tyrozynowej czynnika neurotroficznego

Also Published As

Publication number Publication date
JP7239563B2 (ja) 2023-03-14
JP2021501738A (ja) 2021-01-21
CN113735881A (zh) 2021-12-03
DK3674307T3 (da) 2023-09-11
US20200291042A1 (en) 2020-09-17
AU2018320021C1 (en) 2023-02-23
BR112020003783A2 (pt) 2020-09-01
KR102619444B1 (ko) 2023-12-29
CA3071032A1 (en) 2019-02-28
ES2951427T3 (es) 2023-10-20
RU2020108770A3 (es) 2022-02-28
US11098060B2 (en) 2021-08-24
ZA202001442B (en) 2022-04-28
EP3674307A4 (en) 2021-04-28
WO2019037761A1 (zh) 2019-02-28
AU2018320021A1 (en) 2020-03-12
AU2018320021B2 (en) 2022-04-21
PL3674307T3 (pl) 2023-11-27
EP3674307B1 (en) 2023-06-07
KR20200044062A (ko) 2020-04-28
CN110945000B (zh) 2021-09-03
CN110945000A (zh) 2020-03-31
FI3674307T3 (fi) 2023-09-11
EP3674307A1 (en) 2020-07-01
RU2020108770A (ru) 2021-09-23

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