MX2020001547A - Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol-2,5-diona. - Google Patents
Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol-2,5-diona.Info
- Publication number
- MX2020001547A MX2020001547A MX2020001547A MX2020001547A MX2020001547A MX 2020001547 A MX2020001547 A MX 2020001547A MX 2020001547 A MX2020001547 A MX 2020001547A MX 2020001547 A MX2020001547 A MX 2020001547A MX 2020001547 A MX2020001547 A MX 2020001547A
- Authority
- MX
- Mexico
- Prior art keywords
- fluorobenzofuran
- dione
- pyrrole
- methyl
- solid forms
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 2
- FARXPFGGGGLENU-UHFFFAOYSA-N 3-(5-fluoro-1-benzofuran-3-yl)-4-(5-methyl-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione Chemical compound C12=CC=3OCOC=3C=C2N(C)C=C1C1=C(C=2C3=CC(F)=CC=C3OC=2)C(=O)NC1=O FARXPFGGGGLENU-UHFFFAOYSA-N 0.000 title 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente descripción se refiere a formas sólidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5H-[1,3]dioxolo[4,5-f] indol-7-il)pirrol-2,5-diona, procesos para su preparación, composiciones farmacéuticas de las mismas y usos de las mismas en el tratamiento de enfermedades.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762544277P | 2017-08-11 | 2017-08-11 | |
PCT/US2018/046203 WO2019032958A1 (en) | 2017-08-11 | 2018-08-10 | SOLID FORMS OF 3- (5-FLUOROBENZOFURAN-3-YL) -4- (5-METHYL-5H [1,3] DIOXOLO [4,5-F] INDOL-7-YL) PYRROLE-2,5-DIONE |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020001547A true MX2020001547A (es) | 2020-08-03 |
Family
ID=63405430
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020001547A MX2020001547A (es) | 2017-08-11 | 2018-08-10 | Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol-2,5-diona. |
MX2023005875A MX2023005875A (es) | 2017-08-11 | 2020-02-07 | Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol-2,5-diona. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023005875A MX2023005875A (es) | 2017-08-11 | 2020-02-07 | Formas solidas de 3-(5-fluorobenzofuran-3-il)-4-(5-metil-5h-[1,3]d ioxolo[4,5-f]indol-7-il)pirrol-2,5-diona. |
Country Status (16)
Country | Link |
---|---|
US (2) | US11136334B2 (es) |
EP (1) | EP3665176B1 (es) |
JP (2) | JP7424639B2 (es) |
KR (2) | KR20200040799A (es) |
CN (2) | CN111247153B (es) |
AU (2) | AU2018313259B2 (es) |
BR (1) | BR112020002892A2 (es) |
CA (1) | CA3072240A1 (es) |
DK (1) | DK3665176T3 (es) |
ES (1) | ES2974328T3 (es) |
FI (1) | FI3665176T3 (es) |
IL (1) | IL272556A (es) |
MX (2) | MX2020001547A (es) |
PL (1) | PL3665176T3 (es) |
PT (1) | PT3665176T (es) |
WO (1) | WO2019032958A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018352384B2 (en) | 2017-10-16 | 2023-12-21 | Actuate Therapeutics Inc. | Solid forms of 3-[5-Fluorobenzofuran-3-yl]-4-[5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl] pyrrole-2,5-dione |
CN112437663A (zh) * | 2018-05-17 | 2021-03-02 | 开动疗法公司 | 用β型糖原合酶激酶3抑制剂治疗特发性肺纤维化 |
WO2024006750A1 (en) | 2022-06-27 | 2024-01-04 | Actuate Therapeutics, Inc. | Oral dosage forms of elraglusib |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2446269T3 (es) | 2006-12-19 | 2014-03-06 | The Board Of Trustees Of The University Of Illinois | 3-Benzofuranil-4-indolil-maleimidas como potentes inhibidores de GSK-3 para trastornos neurodegenerativos |
AU2010336533B9 (en) | 2009-12-23 | 2015-10-08 | Arqule, Inc. | Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same |
-
2018
- 2018-08-10 EP EP18760168.7A patent/EP3665176B1/en active Active
- 2018-08-10 FI FIEP18760168.7T patent/FI3665176T3/fi active
- 2018-08-10 KR KR1020207006706A patent/KR20200040799A/ko active IP Right Grant
- 2018-08-10 US US16/638,303 patent/US11136334B2/en active Active
- 2018-08-10 PL PL18760168.7T patent/PL3665176T3/pl unknown
- 2018-08-10 MX MX2020001547A patent/MX2020001547A/es unknown
- 2018-08-10 AU AU2018313259A patent/AU2018313259B2/en active Active
- 2018-08-10 CN CN201880059690.4A patent/CN111247153B/zh active Active
- 2018-08-10 CA CA3072240A patent/CA3072240A1/en active Pending
- 2018-08-10 DK DK18760168.7T patent/DK3665176T3/da active
- 2018-08-10 PT PT187601687T patent/PT3665176T/pt unknown
- 2018-08-10 CN CN202311213594.XA patent/CN117362305A/zh active Pending
- 2018-08-10 KR KR1020247014386A patent/KR20240063198A/ko active Application Filing
- 2018-08-10 ES ES18760168T patent/ES2974328T3/es active Active
- 2018-08-10 JP JP2020530441A patent/JP7424639B2/ja active Active
- 2018-08-10 BR BR112020002892-4A patent/BR112020002892A2/pt unknown
- 2018-08-10 WO PCT/US2018/046203 patent/WO2019032958A1/en unknown
-
2020
- 2020-02-07 MX MX2023005875A patent/MX2023005875A/es unknown
- 2020-02-09 IL IL272556A patent/IL272556A/en unknown
-
2021
- 2021-09-24 US US17/484,025 patent/US20220009939A1/en active Pending
-
2023
- 2023-02-23 AU AU2023201059A patent/AU2023201059A1/en active Pending
- 2023-07-28 JP JP2023123302A patent/JP2023156372A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2020530497A (ja) | 2020-10-22 |
BR112020002892A2 (pt) | 2020-08-04 |
US20220009939A1 (en) | 2022-01-13 |
KR20200040799A (ko) | 2020-04-20 |
EP3665176A1 (en) | 2020-06-17 |
CN111247153B (zh) | 2024-04-02 |
MX2023005875A (es) | 2023-06-05 |
CA3072240A1 (en) | 2019-02-14 |
AU2018313259B2 (en) | 2022-11-24 |
DK3665176T3 (da) | 2024-03-25 |
EP3665176B1 (en) | 2024-01-24 |
US11136334B2 (en) | 2021-10-05 |
AU2023201059A1 (en) | 2023-03-23 |
IL272556A (en) | 2020-03-31 |
PL3665176T3 (pl) | 2024-06-17 |
KR20240063198A (ko) | 2024-05-09 |
JP2023156372A (ja) | 2023-10-24 |
FI3665176T3 (fi) | 2024-03-20 |
US20200223861A1 (en) | 2020-07-16 |
WO2019032958A1 (en) | 2019-02-14 |
ES2974328T3 (es) | 2024-06-26 |
AU2018313259A1 (en) | 2020-02-27 |
CN111247153A (zh) | 2020-06-05 |
CN117362305A (zh) | 2024-01-09 |
JP7424639B2 (ja) | 2024-01-30 |
PT3665176T (pt) | 2024-03-13 |
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