MX2019014759A - Compuestos de azaindol como inhibidores de metiltransferasa de histona. - Google Patents
Compuestos de azaindol como inhibidores de metiltransferasa de histona.Info
- Publication number
- MX2019014759A MX2019014759A MX2019014759A MX2019014759A MX2019014759A MX 2019014759 A MX2019014759 A MX 2019014759A MX 2019014759 A MX2019014759 A MX 2019014759A MX 2019014759 A MX2019014759 A MX 2019014759A MX 2019014759 A MX2019014759 A MX 2019014759A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- histone methyltransferase
- methyltransferase inhibitors
- azaindole compounds
- glp
- Prior art date
Links
- 102000011787 Histone Methyltransferases Human genes 0.000 title abstract 2
- 108010036115 Histone Methyltransferases Proteins 0.000 title abstract 2
- 125000005334 azaindolyl group Chemical class N1N=C(C2=CC=CC=C12)* 0.000 title 1
- 239000003697 methyltransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000005980 beta thalassemia Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000034737 hemoglobinopathy Diseases 0.000 abstract 1
- 208000018337 inherited hemoglobinopathy Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762517410P | 2017-06-09 | 2017-06-09 | |
| PCT/US2018/036521 WO2018226998A1 (en) | 2017-06-09 | 2018-06-07 | Azaindole compounds as histone methyltransferase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019014759A true MX2019014759A (es) | 2020-02-12 |
Family
ID=62779058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019014759A MX2019014759A (es) | 2017-06-09 | 2018-06-07 | Compuestos de azaindol como inhibidores de metiltransferasa de histona. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11111243B2 (enExample) |
| EP (1) | EP3634962B1 (enExample) |
| JP (1) | JP7225125B2 (enExample) |
| CN (1) | CN110997671A (enExample) |
| AR (1) | AR112192A1 (enExample) |
| BR (1) | BR112019025770A2 (enExample) |
| ES (1) | ES2949402T3 (enExample) |
| IL (1) | IL271066A (enExample) |
| MX (1) | MX2019014759A (enExample) |
| TW (1) | TW201920165A (enExample) |
| WO (1) | WO2018226998A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019014759A (es) * | 2017-06-09 | 2020-02-12 | Global Blood Therapeutics Inc | Compuestos de azaindol como inhibidores de metiltransferasa de histona. |
| JP7749679B2 (ja) * | 2021-02-05 | 2025-10-06 | シンノハブ ファーマシューティカル カンパニー，リミティド | プラスミン阻害剤、その製造方法およびその適用 |
| CN114394971B (zh) * | 2022-01-24 | 2023-01-31 | 云南大学 | 一种吲哚咔唑类化合物的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| CA2402549A1 (en) | 2000-03-15 | 2001-09-20 | Aventis Pharma Deutschland Gmbh | Substituted beta-carbolines |
| US20080207632A1 (en) | 2006-10-31 | 2008-08-28 | Supergen, Inc. | Protein kinase inhibitors |
| RU2532135C2 (ru) | 2007-02-22 | 2014-10-27 | Зингента Партисипейшнс Аг | Производные иминопиридина и их применение в качестве микробиоцидов |
| AU2008343932B2 (en) * | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| US8932557B2 (en) * | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| GB2465405A (en) | 2008-11-10 | 2010-05-19 | Univ Basel | Triazine, pyrimidine and pyridine analogues and their use in therapy |
| PL2364983T3 (pl) | 2008-11-11 | 2014-04-30 | Jeil Pharmaceutical Co Ltd | Nowa pochodna tricykliczna lub jej farmaceutycznie dopuszczalne sole, sposób jej wytwarzania, oraz zawierająca ją kompozycja farmaceutyczna |
| PL2485731T4 (pl) * | 2009-10-06 | 2017-07-31 | Millennium Pharmaceuticals, Inc. | Związki heterocykliczne użyteczne jako inhibitory PDK1 |
| WO2011133795A2 (en) * | 2010-04-22 | 2011-10-27 | The Brigham And Women's Hospital, Inc. | Beta-carbolines as inhibitors of haspin and dyrk kinases |
| US9168247B2 (en) * | 2010-06-25 | 2015-10-27 | Facultes Universitaires Notre Dame De La Paix | Beta carboline derivatives useful in the treatment of proliferative disorders |
| TW201236880A (en) | 2011-03-11 | 2012-09-16 | Primax Electronics Ltd | Sheet feeding apparatus |
| KR101606250B1 (ko) | 2011-03-23 | 2016-03-24 | 암젠 인크 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
| US10662193B2 (en) * | 2014-01-21 | 2020-05-26 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins |
| US9284272B2 (en) | 2014-03-28 | 2016-03-15 | Abbvie Inc. | Inhibitors of histone methyltransferase G9a |
| DK3154957T3 (da) | 2014-06-16 | 2020-02-17 | Fundacion Para La Investig Medica Aplicada | Hidtil ukendte forbindelser som dobbelte inhibitorer af histonmethyltransferaser og dna-methyltransferaser |
| US10407423B2 (en) | 2015-11-16 | 2019-09-10 | Fundación Para La Investigación Médica Aplicada | Compounds as inhibitors of DNA methyltransferases |
| MX2019014759A (es) * | 2017-06-09 | 2020-02-12 | Global Blood Therapeutics Inc | Compuestos de azaindol como inhibidores de metiltransferasa de histona. |
-
2018
- 2018-06-07 MX MX2019014759A patent/MX2019014759A/es unknown
- 2018-06-07 WO PCT/US2018/036521 patent/WO2018226998A1/en not_active Ceased
- 2018-06-07 JP JP2019567574A patent/JP7225125B2/ja active Active
- 2018-06-07 BR BR112019025770-5A patent/BR112019025770A2/pt not_active Application Discontinuation
- 2018-06-07 EP EP18735073.1A patent/EP3634962B1/en active Active
- 2018-06-07 ES ES18735073T patent/ES2949402T3/es active Active
- 2018-06-07 US US16/002,408 patent/US11111243B2/en active Active
- 2018-06-07 CN CN201880050882.9A patent/CN110997671A/zh active Pending
- 2018-06-08 AR ARP180101557 patent/AR112192A1/es unknown
- 2018-06-08 TW TW107119935A patent/TW201920165A/zh unknown
-
2019
- 2019-12-01 IL IL271066A patent/IL271066A/en unknown
-
2021
- 2021-08-06 US US17/396,312 patent/US20210371417A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR112192A1 (es) | 2019-10-02 |
| JP2020523315A (ja) | 2020-08-06 |
| JP7225125B2 (ja) | 2023-02-20 |
| IL271066A (en) | 2020-01-30 |
| CN110997671A (zh) | 2020-04-10 |
| EP3634962A1 (en) | 2020-04-15 |
| EP3634962B1 (en) | 2023-05-24 |
| TW201920165A (zh) | 2019-06-01 |
| WO2018226998A1 (en) | 2018-12-13 |
| US20180354947A1 (en) | 2018-12-13 |
| ES2949402T3 (es) | 2023-09-28 |
| US20210371417A1 (en) | 2021-12-02 |
| US11111243B2 (en) | 2021-09-07 |
| BR112019025770A2 (pt) | 2020-06-23 |
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