MX2019010576A - Compuestos polimorficos y usos de los mismos. - Google Patents
Compuestos polimorficos y usos de los mismos.Info
- Publication number
- MX2019010576A MX2019010576A MX2019010576A MX2019010576A MX2019010576A MX 2019010576 A MX2019010576 A MX 2019010576A MX 2019010576 A MX2019010576 A MX 2019010576A MX 2019010576 A MX2019010576 A MX 2019010576A MX 2019010576 A MX2019010576 A MX 2019010576A
- Authority
- MX
- Mexico
- Prior art keywords
- polymorphic compounds
- freebase
- scavenger
- pathogenesis
- implicated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 239000002516 radical scavenger Substances 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/20—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/25—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762472478P | 2017-03-16 | 2017-03-16 | |
| US201762519331P | 2017-06-14 | 2017-06-14 | |
| PCT/US2018/023000 WO2018170476A1 (en) | 2017-03-16 | 2018-03-16 | Polymorphic compounds and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019010576A true MX2019010576A (es) | 2019-10-07 |
Family
ID=63521548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019010576A MX2019010576A (es) | 2017-03-16 | 2018-03-16 | Compuestos polimorficos y usos de los mismos. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10414732B2 (enExample) |
| EP (1) | EP3596040B1 (enExample) |
| JP (2) | JP7648117B2 (enExample) |
| CN (1) | CN110431130A (enExample) |
| AU (1) | AU2018234919A1 (enExample) |
| CA (1) | CA3054811A1 (enExample) |
| ES (1) | ES2968462T3 (enExample) |
| IL (1) | IL268915A (enExample) |
| MX (1) | MX2019010576A (enExample) |
| WO (1) | WO2018170476A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2609659C (en) | 2005-05-26 | 2014-01-28 | Neuron Systems, Inc. | Azanaphthalenes, compositions and methods for treating retinal disease |
| JP5885670B2 (ja) | 2009-12-11 | 2016-03-15 | アルデイラ セラピューティクス， インコーポレイテッド | 黄斑変性の処置のための組成物および方法 |
| CN111135171B (zh) | 2013-01-23 | 2023-09-08 | 奥尔德拉医疗公司 | 与毒性醛相关的疾病和治疗 |
| US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
| EP3419633A4 (en) | 2016-02-28 | 2019-10-30 | Aldeyra Therapeutics, Inc. | TREATMENT OF ALLERGIC EYE DISEASES WITH CYCLODEXTRINS |
| JP7116490B2 (ja) | 2016-05-09 | 2022-08-10 | アルデイラ セラピューティクス， インコーポレイテッド | 眼の炎症性障害および疾患の組合せ処置 |
| WO2018170476A1 (en) | 2017-03-16 | 2018-09-20 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| AU2018348174A1 (en) | 2017-10-10 | 2020-04-23 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
| CN112714762A (zh) | 2018-08-06 | 2021-04-27 | 奥尔德拉医疗公司 | 多晶型化合物及其用途 |
| WO2020068986A1 (en) | 2018-09-25 | 2020-04-02 | Aldeyra Therapeutics, Inc. | Formulations for treatment of dry eye disease |
| EP3894002A1 (en) | 2018-12-12 | 2021-10-20 | Teva Pharmaceuticals International GmbH | Solid state forms of reproxalap |
| WO2020198064A1 (en) | 2019-03-26 | 2020-10-01 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| EP3962894A4 (en) | 2019-05-02 | 2023-01-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND USES THEREOF |
| CA3174416A1 (en) * | 2020-04-13 | 2021-10-21 | Todd Brady | Quinoline compounds for treating lung, liver, and kidney diseases, disorders, or conditions |
| CN115697336A (zh) | 2020-05-13 | 2023-02-03 | 奥尔德拉医疗公司 | 药物制剂及其用途 |
| CN121001726A (zh) * | 2023-03-01 | 2025-11-21 | 里格尔药品股份有限公司 | Syk抑制剂用于治疗化学或辐射诱导的肺损伤的用途 |
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-
2018
- 2018-03-16 WO PCT/US2018/023000 patent/WO2018170476A1/en not_active Ceased
- 2018-03-16 AU AU2018234919A patent/AU2018234919A1/en not_active Abandoned
- 2018-03-16 JP JP2019550247A patent/JP7648117B2/ja active Active
- 2018-03-16 ES ES18767183T patent/ES2968462T3/es active Active
- 2018-03-16 CA CA3054811A patent/CA3054811A1/en not_active Abandoned
- 2018-03-16 US US15/924,005 patent/US10414732B2/en active Active
- 2018-03-16 CN CN201880018663.2A patent/CN110431130A/zh active Pending
- 2018-03-16 MX MX2019010576A patent/MX2019010576A/es unknown
- 2018-03-16 EP EP18767183.9A patent/EP3596040B1/en active Active
-
2019
- 2019-08-26 IL IL26891519A patent/IL268915A/en unknown
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2023
- 2023-01-16 JP JP2023004641A patent/JP2023033426A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL268915A (en) | 2019-10-31 |
| US20180265474A1 (en) | 2018-09-20 |
| EP3596040B1 (en) | 2023-10-11 |
| CN110431130A (zh) | 2019-11-08 |
| EP3596040A4 (en) | 2020-12-16 |
| JP7648117B2 (ja) | 2025-03-18 |
| ES2968462T3 (es) | 2024-05-09 |
| JP2023033426A (ja) | 2023-03-10 |
| JP2020511461A (ja) | 2020-04-16 |
| AU2018234919A1 (en) | 2019-09-19 |
| CA3054811A1 (en) | 2018-09-20 |
| EP3596040A1 (en) | 2020-01-22 |
| WO2018170476A1 (en) | 2018-09-20 |
| US10414732B2 (en) | 2019-09-17 |
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