MX2019010028A - Anticuerpos con cisteina mutada por conjugacion. - Google Patents
Anticuerpos con cisteina mutada por conjugacion.Info
- Publication number
- MX2019010028A MX2019010028A MX2019010028A MX2019010028A MX2019010028A MX 2019010028 A MX2019010028 A MX 2019010028A MX 2019010028 A MX2019010028 A MX 2019010028A MX 2019010028 A MX2019010028 A MX 2019010028A MX 2019010028 A MX2019010028 A MX 2019010028A
- Authority
- MX
- Mexico
- Prior art keywords
- cysteine
- conjugation
- antibody
- numbering
- label
- Prior art date
Links
- 235000018417 cysteine Nutrition 0.000 title abstract 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title abstract 4
- 230000021615 conjugation Effects 0.000 title abstract 2
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 6
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68031—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
Abstract
La invención proporciona regiones constantes modificadas de cadena pesada que incluyen una cisteína en la posición 295 de acuerdo a la numeración EU y opcionalmente en la posición 239 de acuerdo a la numeración EU. Estos residuos de cisteína proporcionan sitios para la conjugación a un fármaco o marca. Cuando ambas cisteínas están presentes en un formato de anticuerpo heterodimérico normal, existen cuatro de esos sitios por molécula de anticuerpo lo que permite una estequiometría de una molécula de anticuerpo por cuatro de fármaco o marca. La selección de cisteína en la posición 295 con o sin cisteína en la posición 239 es ventajosa sobre las cisteínas a muchas otras posiciones debido a la facilidad de expresión, estabilidad y citotoxicidad.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762465129P | 2017-02-28 | 2017-02-28 | |
US201762561151P | 2017-09-20 | 2017-09-20 | |
PCT/US2018/020206 WO2018160683A1 (en) | 2017-02-28 | 2018-02-28 | Cysteine mutated antibodies for conjugation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019010028A true MX2019010028A (es) | 2019-10-14 |
Family
ID=63370994
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019010028A MX2019010028A (es) | 2017-02-28 | 2018-02-28 | Anticuerpos con cisteina mutada por conjugacion. |
Country Status (13)
Country | Link |
---|---|
US (1) | US11938194B2 (es) |
EP (1) | EP3589320A4 (es) |
JP (2) | JP7337698B2 (es) |
KR (1) | KR20190122739A (es) |
CN (1) | CN110352074A (es) |
AU (1) | AU2018227807A1 (es) |
CA (1) | CA3052837A1 (es) |
IL (1) | IL268959A (es) |
MX (1) | MX2019010028A (es) |
NZ (1) | NZ756323A (es) |
SG (1) | SG11201907288RA (es) |
TW (1) | TW201840586A (es) |
WO (1) | WO2018160683A1 (es) |
Families Citing this family (4)
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CA3032147A1 (en) | 2016-08-09 | 2018-02-15 | Seattle Genetics, Inc. | Drug conjugates with self-stabilizing linkers having improved physiochemical properties |
KR20240051956A (ko) | 2021-09-03 | 2024-04-22 | 도레이 카부시키가이샤 | 암의 치료 및/또는 예방용 의약 조성물 |
WO2024052684A1 (en) | 2022-09-09 | 2024-03-14 | MyricX Pharma Limited | Antibody drug conjugate comprising nmt inhibitor and its use |
CN115850449A (zh) * | 2022-09-29 | 2023-03-28 | 苏州智核生物医药科技有限公司 | 抗体和缀合物 |
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TWI823836B (zh) | 2016-07-08 | 2023-12-01 | 美商建南德克公司 | 人類副睪蛋白4(he4)用於評定癌症治療反應性之用途 |
CN109963871A (zh) | 2016-08-05 | 2019-07-02 | 豪夫迈·罗氏有限公司 | 具有激动活性的多价及多表位抗体以及使用方法 |
RU2755899C2 (ru) | 2016-10-11 | 2021-09-22 | Байондис Б.В. | Нелинейные саморасщепляющиеся линкеры и их конъюгаты |
JOP20190187A1 (ar) | 2017-02-03 | 2019-08-01 | Novartis Ag | مترافقات عقار جسم مضاد لـ ccr7 |
US20200095327A1 (en) | 2017-02-08 | 2020-03-26 | Dragonfly Therapeutics, Inc. | Antibody heavy chain variable domains targeting the nkg2d receptor |
-
2018
- 2018-02-28 CN CN201880014692.1A patent/CN110352074A/zh active Pending
- 2018-02-28 JP JP2019546364A patent/JP7337698B2/ja active Active
- 2018-02-28 CA CA3052837A patent/CA3052837A1/en active Pending
- 2018-02-28 KR KR1020197027963A patent/KR20190122739A/ko not_active Application Discontinuation
- 2018-02-28 NZ NZ756323A patent/NZ756323A/en unknown
- 2018-02-28 AU AU2018227807A patent/AU2018227807A1/en active Pending
- 2018-02-28 MX MX2019010028A patent/MX2019010028A/es unknown
- 2018-02-28 SG SG11201907288RA patent/SG11201907288RA/en unknown
- 2018-02-28 WO PCT/US2018/020206 patent/WO2018160683A1/en active Search and Examination
- 2018-02-28 EP EP18760842.7A patent/EP3589320A4/en active Pending
- 2018-02-28 US US16/483,025 patent/US11938194B2/en active Active
- 2018-03-01 TW TW107106880A patent/TW201840586A/zh unknown
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2019
- 2019-08-27 IL IL26895919A patent/IL268959A/en unknown
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2023
- 2023-08-23 JP JP2023135767A patent/JP2023159335A/ja active Pending
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JP2020509010A (ja) | 2020-03-26 |
US20220175947A1 (en) | 2022-06-09 |
KR20190122739A (ko) | 2019-10-30 |
JP7337698B2 (ja) | 2023-09-04 |
EP3589320A4 (en) | 2020-12-23 |
WO2018160683A1 (en) | 2018-09-07 |
TW201840586A (zh) | 2018-11-16 |
IL268959A (en) | 2019-10-31 |
CA3052837A1 (en) | 2018-09-07 |
CN110352074A (zh) | 2019-10-18 |
SG11201907288RA (en) | 2019-09-27 |
NZ756323A (en) | 2022-07-01 |
EP3589320A1 (en) | 2020-01-08 |
US11938194B2 (en) | 2024-03-26 |
JP2023159335A (ja) | 2023-10-31 |
AU2018227807A1 (en) | 2019-08-22 |
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