MX2019008894A - Purificacion de pleuromutilina. - Google Patents

Purificacion de pleuromutilina.

Info

Publication number
MX2019008894A
MX2019008894A MX2019008894A MX2019008894A MX2019008894A MX 2019008894 A MX2019008894 A MX 2019008894A MX 2019008894 A MX2019008894 A MX 2019008894A MX 2019008894 A MX2019008894 A MX 2019008894A MX 2019008894 A MX2019008894 A MX 2019008894A
Authority
MX
Mexico
Prior art keywords
pleuromutilin
purification
present
propylacetate
recrystallisation
Prior art date
Application number
MX2019008894A
Other languages
English (en)
Inventor
Heilmayer Werner
Hinsmann Peter
Spence Lee
Original Assignee
Nabriva Therapeutics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nabriva Therapeutics GmbH filed Critical Nabriva Therapeutics GmbH
Publication of MX2019008894A publication Critical patent/MX2019008894A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/675—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids of saturated hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/36—Ortho- or ortho- and peri-condensed systems containing three rings containing eight-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/95—Spiro compounds containing "not free" spiro atoms
    • C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
    • C07C2603/99—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con métodos de purificación de la pleuromutilina (I) por medio de la cristalización y/o la recristalización. El proceso de acuerdo con la presente invención se lleva a cabo en la presencia del i-propilacetato.
MX2019008894A 2017-02-10 2018-02-09 Purificacion de pleuromutilina. MX2019008894A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17155542 2017-02-10
PCT/EP2018/053314 WO2018146264A1 (en) 2017-02-10 2018-02-09 Purification of pleuromutilin

Publications (1)

Publication Number Publication Date
MX2019008894A true MX2019008894A (es) 2019-10-09

Family

ID=58017956

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019008894A MX2019008894A (es) 2017-02-10 2018-02-09 Purificacion de pleuromutilina.

Country Status (13)

Country Link
US (1) US10913703B2 (es)
EP (1) EP3580197B1 (es)
JP (1) JP7086974B2 (es)
KR (1) KR102509871B1 (es)
CN (1) CN110225903B (es)
CA (1) CA3051643A1 (es)
DK (1) DK3580197T3 (es)
ES (1) ES2858431T3 (es)
IL (1) IL268550B (es)
MX (1) MX2019008894A (es)
PT (1) PT3580197T (es)
TW (1) TWI762573B (es)
WO (1) WO2018146264A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113354538A (zh) * 2020-03-03 2021-09-07 新疆上昵生物科技有限公司 一种高纯度截短侧耳素的提取方法
WO2021209173A1 (en) * 2020-04-17 2021-10-21 Nabriva Therapeutics GmbH Novel therapeutic use of pleuromutilins
JP2023548968A (ja) * 2020-10-29 2023-11-21 エランコ ティーアゲズンタイト アーゲー プレウロムチリン類を精製する方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092424A (en) 1964-04-17 1978-05-30 Biochemie Ges.M.B.H. Antibiotic derivatives
GB1197942A (en) 1967-08-15 1970-07-08 Biochemie Gmbh Process for the production of the Antibiotic Pleuromutilin
US4129721A (en) 1977-12-08 1978-12-12 Eli Lilly And Company A-40104 antibiotics and process for production thereof
US4247542A (en) 1978-06-22 1981-01-27 Eli Lilly And Company A-40104 Antibiotics and process for production thereof
WO1997025309A1 (en) 1996-01-03 1997-07-17 Smithkline Beecham Plc Carbamoyloxy derivatives of mutiline and their use as antibacterials
HUP0001741A3 (en) 1996-08-02 2000-11-28 Smithkline Beecham Plc Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use, process for preparing them, pharmaceuticals contg. them and their use
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB9918037D0 (en) 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0017031D0 (en) 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
PE20020676A1 (es) 2000-09-13 2002-08-27 Biochemie Gmbh Compuestos de mutilina como antibacterianos
GB0207495D0 (en) 2002-03-28 2002-05-08 Biochemie Gmbh Organic compounds
GB0209262D0 (en) 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
WO2004011431A1 (en) 2002-07-24 2004-02-05 Sandoz Ag Pleuromutilin derivatives as antimicrobbials
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
ATE450535T1 (de) 2003-09-03 2009-12-15 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
EP1863768A1 (en) 2004-12-13 2007-12-12 Glaxo Group Limited Novel polymorph of (5-amino-6-methoxy-3-pyridincarbonyl)carbamic acid 2-(s)-hydroxymutilin 14-ester
GB0504314D0 (en) * 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
JP2008534443A (ja) 2005-03-10 2008-08-28 スミスクライン・ビーチャム・コーポレイション 新規な方法
EP2298733B1 (en) 2005-06-27 2016-05-25 Nabriva Therapeutics AG Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
GB0513058D0 (en) 2005-06-27 2005-08-03 Sandoz Ag Organic compounds
GB0515995D0 (en) 2005-08-03 2005-09-07 Sandoz Ag Organic compounds
TW200736203A (en) 2005-11-18 2007-10-01 Glaxo Group Ltd New pleuromutilin derivative and its use
TW200738599A (en) 2005-11-18 2007-10-16 Glaxo Group Ltd New pleuromutilin derivative and its use
EP1808431A1 (en) 2006-01-16 2007-07-18 Nabriva Therapeutics Forschungs GmbH Mutilin derivatives and their use as pharmaceutical
EP1908750A1 (en) 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Process for the preparation of pleuromutilins
EP1972618A1 (en) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2014640A1 (en) 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives
EP2014645A1 (en) 2007-07-13 2009-01-14 Nabriva Therapeutics AG Pleuromutilin derivatives and their use as antimicrobials
EP2159220A1 (en) 2008-09-02 2010-03-03 Nabriva Therapeutics AG Organic compounds
CN101838199B (zh) * 2010-05-21 2013-01-30 西南大学 截短侧耳素的溶剂提取工艺
EP2399904A1 (en) * 2010-05-26 2011-12-28 Nabriva Therapeutics AG Process for the preparation of pleuromutilins
EP2390245A1 (en) 2010-05-26 2011-11-30 Nabriva Therapeutics AG Enantiomerically pure amines
EP2433926A1 (en) 2010-09-09 2012-03-28 Nabriva Therapeutics AG Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes
CN102050737B (zh) * 2010-12-10 2013-05-08 山东胜利股份有限公司 一种截短侧耳素的提取纯化方法
CN102351698A (zh) * 2011-08-15 2012-02-15 上海华震科技有限公司 一种用吸附色谱法从结晶母液中回收截短侧耳素的方法
JP6715772B2 (ja) 2014-01-22 2020-07-01 ナブリヴァ セラピュティクス ゲーエムベーハー １２−ｅｐｉ−プロイロムチリン

Also Published As

Publication number Publication date
PT3580197T (pt) 2021-03-02
US20200231529A1 (en) 2020-07-23
CA3051643A1 (en) 2018-08-16
IL268550A (en) 2019-09-26
CN110225903B (zh) 2022-02-08
ES2858431T3 (es) 2021-09-30
US10913703B2 (en) 2021-02-09
TWI762573B (zh) 2022-05-01
JP2020507572A (ja) 2020-03-12
EP3580197A1 (en) 2019-12-18
IL268550B (en) 2021-05-31
CN110225903A (zh) 2019-09-10
EP3580197B1 (en) 2020-12-02
WO2018146264A1 (en) 2018-08-16
TW201835024A (zh) 2018-10-01
DK3580197T3 (da) 2021-02-08
JP7086974B2 (ja) 2022-06-20
KR20190117504A (ko) 2019-10-16
KR102509871B1 (ko) 2023-03-14

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